Mitochondrial Reactive Oxygen Species and Lytic Programmed Cell Death in Acute Inflammation DOI Creative Commons
Sergio Rius‐Pérez, Salvador Pérez, Michel B. Tolédano

et al.

Antioxidants and Redox Signaling, Journal Year: 2023, Volume and Issue: 39(10-12), P. 708 - 727

Published: July 14, 2023

Significance: Redox signaling through mitochondrial reactive oxygen species (mtROS) has a key role in several mechanisms of regulated cell death (RCD), necroptosis, ferroptosis, pyroptosis, and apoptosis, thereby decisively contributing to inflammatory disorders. The mtROS apoptosis been extensively addressed, but their involvement necrotic-like RCD just started being elucidated, providing novel insights into the pathophysiology acute inflammation. Recent Advances: p53 together with drive necroptosis inflammation downregulation sulfiredoxin peroxiredoxin 3. Mitochondrial hydroorotate dehydrogenase is redox system regulation ferroptosis. In addition, noncanonical pathway, which generates Ragulator-Rag complex acts via mTORC1 promote gasdermin D oligomerization, triggers pyroptosis. Critical Issues: trigger positive feedback loops leading lytic conjunction necrosome, inflammasome, glutathione depletion, peroxidase 4 deficiency. Future Directions: precise mechanism membrane rupture ferroptosis contribution disorders are still unclear, will need further research. antioxidants may provide promising therapeutic approaches toward However, establishing doses windows action be required optimize potential, avoid potential adverse side effects linked blockade beneficial adaptive signaling. Antioxid. Signal. 39, 708-727.

Language: Английский

Molecular mechanisms of ferroptosis and relevance to inflammation DOI Open Access

Liyan Deng,

Shasha He,

Nuoqing Guo

et al.

Inflammation Research, Journal Year: 2022, Volume and Issue: 72(2), P. 281 - 299

Published: Dec. 19, 2022

Language: Английский

Citations

139
STAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53/SLC7A11 pathway DOI Creative Commons
Youjing Yang, Yu Ma, Qianmin Li

et al.

Cell Death and Disease, Journal Year: 2022, Volume and Issue: 13(6)

Published: June 6, 2022

Abstract Compelling evidences have revealed the emerging role of ferroptosis in pathophysiological process acute lung injury (ALI), but its modulation is not clear. Here, we identified that STAT6 acted as a critical regulator epithelium during ALI. Firstly, expression and activity were increased ALI mice models caused by crystalline silica (CS), LPS X-ray exposure. Followed confirming contribution above with ferrostatin-1 deferoxamine intervention, bioinformatic analyses was negatively correlated ferroptosis. Consistently, epithelium-specific depletion or knockdown cultured epithelial cells exacerbated While overexpression attenuated Mechanistically, SLC7A11 typical ferroptosis-related gene regulated P53. CREB-binding protein (CBP) acetyltransferase P53 acetylation, showing valuable regulation on targets’ transcription. Herein, found regulates through competitively binding CBP, which inhibits acetylation transcriptionally restores expression. Finally, pulmonary-specific decreased CS induced injury. Our findings pivotal ferroptosis, may be potential therapeutic target for treatment

Language: Английский

Citations

112
The role of ferroptosis mediated by NRF2/ERK-regulated ferritinophagy in CdTe QDs-induced inflammation in macrophage DOI
Na Liu, Ying Liang, Tingting Wei

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 436, P. 129043 - 129043

Published: May 4, 2022

Language: Английский

Citations

81
Astaxanthin attenuates ferroptosis via Keap1-Nrf2/HO-1 signaling pathways in LPS-induced acute lung injury DOI
Lianxiang Luo, Fangfang Huang,

Saiyi Zhong

et al.

Life Sciences, Journal Year: 2022, Volume and Issue: 311, P. 121091 - 121091

Published: Oct. 14, 2022

Language: Английский

Citations

79
Genetic analysis of diagnostic and therapeutic potential for ferroptosis in postoperative sepsis DOI Creative Commons

Shuaijie Pei,

J. B. Liu, Zhiwei Wang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 114042 - 114042

Published: Jan. 9, 2025

Language: Английский

Citations

2
Ferroptosis and Its Role in Chronic Diseases DOI Creative Commons
Wenli Hu, Kehong Liang, Hong Zhu

et al.

Cells, Journal Year: 2022, Volume and Issue: 11(13), P. 2040 - 2040

Published: June 27, 2022

Ferroptosis, which has been widely associated with many diseases, is an iron-dependent regulated cell death characterized by intracellular lipid peroxide accumulation. It exhibits morphological, biochemical, and genetic characteristics that are unique in comparison to other types of death. The course ferroptosis can be accurately the metabolism iron, lipids, amino acids, various signal pathways. In this review, we summarize basic ferroptosis, its regulation, as well relationship between chronic diseases such cancer, nervous system metabolic inflammatory bowel diseases. Finally, describe regulatory effects food-borne active ingredients on ferroptosis.

Language: Английский

Citations

62
Melatonin suppresses ferroptosis via activation of the Nrf2/HO-1 signaling pathway in the mouse model of sepsis-induced acute kidney injury DOI

Weihuang Qiu,

Sheng An, Tingjie Wang

et al.

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 112, P. 109162 - 109162

Published: Sept. 5, 2022

Language: Английский

Citations

58
Ferroptosis, a New Insight Into Acute Lung Injury DOI Creative Commons

Xiaofang Yin,

Guisong Zhu,

Qian Wang

et al.

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Aug. 2, 2021

Acute lung injury (ALI), a common and critical illness with high morbidity mortality, is caused by multiple causes. It has been confirmed that oxidative stress plays an important role in the development of ALI. Ferroptosis, newly discovered programmed cell death 2012, characterized iron-dependent lipid peroxidation involved many diseases. To date, compelling evidence reveals emerging ferroptosis pathophysiological process Here, we review pathogenesis ALI its therapeutic potential

Language: Английский

Citations

56
The role of ferroptosis in acute lung injury DOI Open Access
Xin Liu, Junqiang Zhang, Wang Xie

et al.

Molecular and Cellular Biochemistry, Journal Year: 2022, Volume and Issue: 477(5), P. 1453 - 1461

Published: Feb. 15, 2022

Language: Английский

Citations

55
Urolithin A (UA) attenuates ferroptosis in LPS-induced acute lung injury in mice by upregulating Keap1-Nrf2/HO-1 signaling pathway DOI Creative Commons

Lejing Lou,

Min Wang, Jingjing He

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: March 9, 2023

Acute lung injury (ALI) is a life-threatening disease with high incidence and mortality rates. Urolithin A (UA) pomegranate intestinal flora metabolite anti-inflammatory, antioxidant, anti-aging properties. Ferroptosis critical factor in lipopolysaccharide (LPS)-induced acute (ALI). However, the link between UA ferroptosis unknown. The purpose of this research was to look into role regulating LPS-induced ALI. current study used LPS injure two models, one BEAS-2B cell model ALI mouse model. effectively alleviated compared group by lowering vivo wet/dry weight ratio, reactive oxygen species, malondialdehyde production, as well superoxide dismutase, catalase, glutathione depletion. Furthermore, increasing GPX4 SLC7A11 expression decreasing Fe2+ levels, histopathological damage, inflammatory cytokine secretion, levels can be significantly reduced. Keap1-Nrf2/HO-1 pathway upregulated UA, which inhibited ferroptosis. ML385 UA's protective effect against These findings suggested that could novel potential therapeutic target for

Language: Английский

Citations

36