Archives of Gerontology and Geriatrics Plus,
Journal Year:
2024,
Volume and Issue:
1(3), P. 100034 - 100034
Published: May 7, 2024
The
potential
contributions
of
neuromuscular
junction
(NMJ)
degradation
to
muscle
loss
in
cancer
remain
poorly
understood.
We
investigated
the
biomarkers
NMJ
decline
patients
with
gynecological
carcinomas.
recruited
women
endometrial
(n=37,
56-73
years
old)
or
ovarian
(n=40,
55-72
carcinomas
along
age-matched
controls
(n=47,
55-71
controls,
divided
into
two
subgroups
based
on
presence
age-associated
loss,
termed
sarcopenia.
measured
plasma
c-terminal
agrin-fragment-32
(CAF22;
biomarker
loss),
neurofilament
light
chain
(NF-L;
neurodegeneration),
handgrip
strength
(HGS),
appendicular
skeletal
mass
index
(AMMI),
and
short
physical
performance
battery
(SPPB;
marker
capacity).
Patients
exhibits
low
HGS,
AMMI,
SPPB
higher
NF-L
levels
than
(all
p<0.05).
found
a
modest
elevation
CAF22
but
not
sarcopenia
was
associated
further
levels.
Higher
carcinoma
stages
were
both
groups
patients.
Collectively,
may
have
contribution
strategies
counter
target
intrinsic
changes
within
independent
NMJ.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(8), P. 2405 - 2405
Published: April 20, 2024
The
therapeutic
management
and
short-term
consequences
of
the
coronavirus
disease
2019
(COVID-19)
are
well
known.
However,
COVID-19
post-acute
sequelae
less
known
represent
a
public
health
problem
worldwide.
Patients
with
who
present
may
display
immune
dysregulation,
procoagulant
state,
persistent
microvascular
endotheliopathy
that
could
trigger
thrombosis.
These
elements
have
also
been
implicated
in
physiopathology
postural
orthostatic
tachycardia
syndrome,
frequent
sequela
post-COVID-19
patients.
mechanisms,
directly
associated
sequelae,
might
determine
thrombotic
need
for
early
anticoagulation
therapy.
In
this
context,
heparin
has
several
potential
benefits,
including
immunomodulatory,
anticoagulant,
antiviral,
pro-endothelial,
vascular
effects,
be
helpful
treatment
sequelae.
article,
we
review
evidence
surrounding
benefits
use
heparin,
special
focus
on
syndrome.
Archives of Gerontology and Geriatrics Plus,
Journal Year:
2024,
Volume and Issue:
1(3), P. 100034 - 100034
Published: May 7, 2024
The
potential
contributions
of
neuromuscular
junction
(NMJ)
degradation
to
muscle
loss
in
cancer
remain
poorly
understood.
We
investigated
the
biomarkers
NMJ
decline
patients
with
gynecological
carcinomas.
recruited
women
endometrial
(n=37,
56-73
years
old)
or
ovarian
(n=40,
55-72
carcinomas
along
age-matched
controls
(n=47,
55-71
controls,
divided
into
two
subgroups
based
on
presence
age-associated
loss,
termed
sarcopenia.
measured
plasma
c-terminal
agrin-fragment-32
(CAF22;
biomarker
loss),
neurofilament
light
chain
(NF-L;
neurodegeneration),
handgrip
strength
(HGS),
appendicular
skeletal
mass
index
(AMMI),
and
short
physical
performance
battery
(SPPB;
marker
capacity).
Patients
exhibits
low
HGS,
AMMI,
SPPB
higher
NF-L
levels
than
(all
p<0.05).
found
a
modest
elevation
CAF22
but
not
sarcopenia
was
associated
further
levels.
Higher
carcinoma
stages
were
both
groups
patients.
Collectively,
may
have
contribution
strategies
counter
target
intrinsic
changes
within
independent
NMJ.
