Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi,
Journal Year:
2024,
Volume and Issue:
17(1), P. 164 - 173
Published: March 27, 2024
Breast
cancer
is
a
major
global
health
problem
that
imposes
significant
social
and
economic
burden
on
individuals
societies.
Chemotherapy,
common
treatment
approach,
often
leads
to
resistance
unwanted
side
effects,
especially
in
the
advanced
stages
of
disease.
This
has
led
search
for
more
effective
less
toxic
anticancer
agents.
Lichens,
which
are
associations
fungi
algae,
gaining
attention
their
potential
therapy.
Lichens
rich
sources
secondary
metabolites
with
diverse
biological
including
anti-tumor
properties.
In
this
study,
we
summarise
combined
effects
vulpinic
acid
(VA),
lichen
acid,
doxorubicin,
chemotherapeutic
drug,
breast
MCF-7
cells.
The
results
XTT
assay
subsequent
Compsyn
analysis
showed
VA
doxorubicin
(Dox),
alone
exhibited
potent
anti-proliferative
dose-
time-dependent
manner,
interestingly,
when
used
combination,
they
produced
an
antagonistic
effect
same
line.
These
provide
first
example
study
show
what
combination
Dox
will
have
other
cell
lines.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5675 - 5675
Published: May 23, 2024
According
to
the
World
Health
Organization
(WHO),
breast
cancer
(BC)
is
deadliest
and
most
common
type
of
worldwide
in
women.
Several
factors
associated
with
BC
exert
their
effects
by
modulating
state
stress.
They
can
induce
genetic
mutations
or
alterations
cell
growth,
encouraging
neoplastic
development
production
reactive
oxygen
species
(ROS).
ROS
are
able
activate
many
signal
transduction
pathways,
producing
an
inflammatory
environment
that
leads
suppression
programmed
death
promotion
tumor
proliferation,
angiogenesis,
metastasis;
these
promote
progression
malignant
neoplasms.
However,
cells
have
both
non-enzymatic
enzymatic
antioxidant
systems
protect
them
neutralizing
harmful
ROS.
In
this
sense,
enzymes
such
as
superoxide
dismutase
(SOD),
catalase
(CAT),
glutathione
peroxidase
(GPx),
reductase
(GR),
thioredoxin
(TrxR),
peroxiredoxin
(Prx)
body
from
diseases
caused
oxidative
damage.
review,
we
will
discuss
mechanisms
through
which
some
antioxidants
inhibit
carcinogenesis,
well
new
therapeutic
proposals
developed
complement
traditional
treatments.
Journal of Applied Toxicology,
Journal Year:
2023,
Volume and Issue:
43(8), P. 1148 - 1158
Published: Feb. 21, 2023
Abstract
Thioredoxin
reductase
1
(TrxR1)
has
emerged
as
an
important
target
for
anticancer
drug
development
due
to
its
overexpression
in
many
human
tumors
including
breast
cancer.
Due
the
serious
side
effects
of
currently
used
commercial
drugs,
new
natural
compounds
with
very
few
and
high
efficacy
are
great
importance
cancer
treatment.
Lichen
secondary
metabolites,
known
compounds,
have
diverse
biological
properties,
antioxidant
activities.
Herein,
we
aimed
determine
potential
antiproliferative,
antimigratory,
apoptotic
evernic
acid,
a
lichen
metabolite,
on
MCF‐7
MDA‐MB‐453
cell
lines
afterward
investigate
whether
effect
is
exerted
by
TrxR1‐targeting.
The
cytotoxicity
results
indicated
that
acid
suppressed
proliferation
cells
dose‐dependent
manner
IC
50
values
were
calculated
33.79
121.40
μg/mL,
respectively.
Migration
assay
revealed
notable
antimigratory
ability
against
both
types.
expression
markers
Bcl2
associated
X,
apoptosis
regulator,
tumor
protein
p53
quantitative
real‐time
polymerase
chain
reaction
western
blot
analysis
showed
did
not
induce
lines,
consistent
flow
cytometry
results.
Evernic
via
inhibiting
TrxR1
enzyme
activity
rather
than
mRNA
levels
lines.
In
conclusion,
these
findings
suggest
be
evaluated
therapeutic
agent
Chemistry & Biodiversity,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 26, 2025
ABSTRACT
The
aim
of
this
study
was
to
determine
the
secondary
metabolites
n
‐hexane,
ethyl
acetate,
methanol,
and
water
extracts
Achillea
sintenisii
Hub.
Mor.
ascertain
their
divergent
biological
properties.
LC–MS/MS
analysis
performed
identify
bioactive
compounds.
anticancer
properties
samples
were
tested
against
human
breast
(MCF‐7
MDA‐MB‐453)
colon
(HT‐29)
cancer
cell
lines
by
XTT
assay.
anti‐Alzheimer's
studies
using
Ellman's
antimicrobial
carried
out
Kirby–Bauer
disc
diffusion
method.
antioxidative
potential
evaluated
on
basis
2,2‐diphenyl‐1‐picrylhydrazyl
scavenging
ferric
reducing
antioxidant
power
assays,
revealed
27
phytochemicals,
including
high
concentrations
quinic
acid,
gentisic
chlorogenic
luteolin,
cynaroside,
caffeic
acid.
Ethyl
acetate
extract
exhibited
most
potent
cytoxicity
MDA‐MB‐453
cells,
with
an
IC
50
value
83.05
µg/mL.
All
showed
stronger
inhibitory
activity
acetylcholinesterase
butyrylcholinesterase
compared
tacrine.
methanol
considerable
Enterococcus
faecalis
,
approaching
level
vancomycin.
Methanol
possessed
highest
DPPH
power.
These
findings
render
A,
a
promising
source
for
pharmaceutical,
cosmetic,
food
industries.
Naunyn-Schmiedeberg s Archives of Pharmacology,
Journal Year:
2024,
Volume and Issue:
397(8), P. 5745 - 5755
Published: Feb. 3, 2024
Hepatocellular
carcinoma
(HCC)
represents
one
of
the
most
common
malignant
tumors
worldwide.
Due
to
limited
number
available
drugs
and
their
side
effects,
development
new
chemotherapeutic
strategies
for
HCC
treatment
has
become
increasingly
important.
This
study
is
aimed
at
investigating
whether
diffractaic
acid
(DA),
secondary
metabolites
lichen,
exhibits
a
potential
anticancer
effect
on
HepG2
cells
its
mediated
by
inhibition
thioredoxin
reductase
1
(TRXR1),
which
target
due
overexpression
in
tumor
including
HCC.
XTT
assay
results
showed
that
DA
exhibited
strong
cytotoxicity
with
an
IC
Chemical Biology & Drug Design,
Journal Year:
2023,
Volume and Issue:
101(6), P. 1273 - 1282
Published: Feb. 9, 2023
Herein,
two
iridoid
glucosides
aucubin
(1)
and
ajugol
(2),
phenyl
ethanoids,
verbascoside
(3)
poliumoside
(4)
were
isolated
from
the
methanol
extract
of
aerial
parts
Verbascum
speciosum
used
to
study
about
their
anticancer
activity
for
first
time.
The
structures
all
compounds
elucidated
using
spectroscopic
data
(IR,
1D
2D
NMR,
LC-TOF/MS).
Antiproliferative
activities
Aucubun
Verbascoside
tested
against
A-549
(human
colon
cancer),
MDA-MD-453
breast
cancer)
3T3-L1
(mouse
fibroblast)cell
lines
by
XTT
assay.
In
addition,
anticarcer
mechanism
action
was
investigated
on
MDA-MB-453
cells
result
showed
that
both
applied
exhibited
antiproliferative
effect
at
different
dose
ranges
depending
cancer
type,
as
well
selectivity
between
healty
cell
lines.
Flow
cytometry
analyzes
revealed
exerts
its
cytotoxic
in
directing
early
apoptosis
inhibiting
P13K/AKT
signaling
pathway.
Fermentation,
Journal Year:
2024,
Volume and Issue:
10(3), P. 157 - 157
Published: March 9, 2024
Penicillium
is
a
kind
of
common
filamentous
fungi
yielding
high
levels
secondary
metabolites
with
diverse
structures
and
attractive
activities.
Among
these
fungi,
janthinellum
potential
producer
whose
natural
products
have
been
noticed
due
to
their
various
chemical
biological
This
review
summarizes
the
sources,
distribution,
bioactivities
structural
characteristics
compounds
isolated
from
P.
1980
2023.
A
total
153
janthinellum,
which
65
were
new
compounds.
The
separated
exhibit
skeletal
structures,
concentrated
in
categories
polyketides
(40%),
alkaloids
(31%)
terpenoids
(14%).
janthinellum-derived
display
activities,
such
as
cytotoxic,
antibacterial,
antifungal
antiviral
These
results
indicate
that
fungus
for
producing
bioactive
can
be
used
precursors
drugs.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(4)
Published: Jan. 23, 2024
Abstract
Schiff
base
ligands
and
their
metal
complexes
play
a
great
important
role
in
pharmaceutical
sciences
because
of
wide
significant
activities.
They
are
versatile
pharmacophores
for
the
design
discovery
many
drugs.
In
this
study,
ligand
its
were
synthesized.
Some
spectroscopic
techniques
such
as
FT‐IR,
1
H‐NMR,
13
C‐NMR,
XRD,
SEM,
UV‐Vis
used
structural
characterization.
Antiproliferative
activities
synthesized
investigated
on
human
breast
(MCF‐7)
colon
(HT‐29)
cancer
cell
lines
by
XTT
[2,3‐Bis(2‐methoxy‐4‐nitro‐5‐sulfophenyl)‐2H‐tetrazolium]
method.
The
obtained
data
showed
that
exhibited
dose‐dependent
cell‐selective
vitro
antiproliferative
activity
tested
line.
addition,
it
was
determined
statistically
higher
cytotoxic
compared
to
ligand.
binding
parameter
values
amino
acids
site
between
possible
lead
compounds
molecular
docking
from
silico
approaches
target.
A
study
cobalt
complex
performed
against
Bcl‐2
(PDB
ID:4IEH)
DNA
recognition
ID:423D)
targets.
conclusion,
these
show
have
potential
be
evaluated
chemotherapeutic
agent.
