Antimicrobial Potential of Secalonic Acids from Arctic-Derived Penicillium chrysogenum INA 01369 DOI Creative Commons

Yulia A. Roshka,

Н. Н. Маркелова, Sofia D. Mashkova

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(1), P. 88 - 88

Published: Jan. 14, 2025

In this study, two compounds have been isolated from the Arctic-derived fungus Penicillium chrysogenum INA 13460. Structural elucidation, performed using 2D NMR and HR-ESIMS data, has identified as stereoisomers of secalonic acids, dimeric tetrahydroxanthones. The absolute configurations these determined through conformational analysis circular dichroism spectroscopy. antimicrobial activity acids D F evaluated against a diverse range microorganisms, including Gram-positive multidrug-resistant Staphylococcus aureus, Gram-negative Escherichia coli ATCC 25922, Pseudomonas aeruginosa 27853, phytopathogen Pectobacterium carotovorum VKM-B1247, fungi Fusarium oxysporum VKPM 890, Aspergillus fumigatus VKM F-37, A. niger 16404. Genomic chemical analyses further support P. 13460 promising natural source for drug discovery biological control applications.

Language: Английский

A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment DOI Creative Commons

Khushbu Wadhwa,

Neha Kapoor,

Hardeep Kaur

et al.

Mycobiology, Journal Year: 2024, Volume and Issue: 52(6), P. 335 - 387

Published: Nov. 1, 2024

Fungi and their natural products, like secondary metabolites, have gained a huge demand in the last decade due to increasing applications healthcare, environmental cleanup, biotechnology-based industries. The fungi produce these metabolites (SMs) during different phases of growth, which are categorized into terpenoids, alkaloids, polyketides, non-ribosomal peptides. These SMs exhibit significant biological activity, contributes formulation novel pharmaceuticals, biopesticides, bioremediation agents. Nowadays, fungal-derived widely used food beverages, for fermentation, preservatives, protein sources, dairy In it is being as an antimicrobial, anticancer, anti-inflammatory, immunosuppressive drug. usage modern tools biotechnology can achieve increase large-scale production. present review comprehensively analyses diversity fungal along with emerging agriculture, sustainability, nutraceuticals. Here, authors reviewed recent advancements genetic engineering, metabolic pathway manipulation, synthetic biology improve production yield SMs. Advancement fermentation techniques, bioprocessing, co-cultivation approaches Investigators further highlighted importance omics technologies understanding regulation biosynthesis SMs, offers drug discovery sustainable agriculture. Finally, addressed potential manipulation biotechnological innovations exploitation commercial benefits.

Language: Английский

Citations

4
Antimicrobial Potential of Secalonic Acids from Arctic-Derived Penicillium chrysogenum INA 01369 DOI Creative Commons

Yulia A. Roshka,

Н. Н. Маркелова, Sofia D. Mashkova

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(1), P. 88 - 88

Published: Jan. 14, 2025

In this study, two compounds have been isolated from the Arctic-derived fungus Penicillium chrysogenum INA 13460. Structural elucidation, performed using 2D NMR and HR-ESIMS data, has identified as stereoisomers of secalonic acids, dimeric tetrahydroxanthones. The absolute configurations these determined through conformational analysis circular dichroism spectroscopy. antimicrobial activity acids D F evaluated against a diverse range microorganisms, including Gram-positive multidrug-resistant Staphylococcus aureus, Gram-negative Escherichia coli ATCC 25922, Pseudomonas aeruginosa 27853, phytopathogen Pectobacterium carotovorum VKM-B1247, fungi Fusarium oxysporum VKPM 890, Aspergillus fumigatus VKM F-37, A. niger 16404. Genomic chemical analyses further support P. 13460 promising natural source for drug discovery biological control applications.

Language: Английский

Citations

0