Asian Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
19(3), P. 100910 - 100910
Published: April 13, 2024
The
early
diagnosis
of
cancer
is
vital
for
effective
treatment
and
improved
prognosis.
Tumor
biomarkers,
which
can
be
used
the
diagnosis,
treatment,
prognostic
evaluation
cancer,
have
emerged
as
a
topic
intense
research
interest
in
recent
years.
Nucleic
acid,
type
tumor
biomarker,
contains
genetic
information,
great
significance
occurrence
development
cancer.
Currently,
living
cell
nucleic
acid
probes,
enable
Journal of Functional Biomaterials,
Journal Year:
2023,
Volume and Issue:
14(2), P. 115 - 115
Published: Feb. 18, 2023
Skin
wounds
have
imposed
serious
socioeconomic
burdens
on
healthcare
providers
and
patients.
There
are
just
more
than
25,000
burn
injury-related
deaths
reported
each
year.
Conventional
treatments
do
not
often
allow
the
re-establishment
of
function
affected
regions
structures,
resulting
in
dehydration
wound
infections.
Many
nanocarriers,
such
as
lipid-based
systems
or
biobased
biodegradable
polymers
their
associated
platforms,
favorable
healing
due
to
ability
promote
cell
adhesion
migration,
thus
improving
reducing
scarring.
Hence,
many
researchers
focused
developing
new
dressings
based
compounds
with
desirable
effects.
However,
when
applied
healing,
some
problems
occur,
high
cost
public
health,
novel
emphasizing
reduced
costs,
increasing
quality
treatment
outcomes.
The
integrated
hybrid
nanocarriers
(LNCs)
polymer-based
can
be
promising
solution
for
above
process.
Furthermore,
drug
delivery
showed
effective
release
therapeutic
agents,
suitable
mimicking
physiological
environment,
improvement
single
system.
This
review
highlights
recent
advances
role
carriers
healing.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(6), P. 3535 - 3555
Published: May 20, 2024
Alzheimer's
disease
(AD)
is
a
neurological
condition
currently
with
47
million
people
suffering
from
it
globally.
AD
might
have
many
reasons
such
as
genetic
issues,
environmental
factors,
and
Aβ
accumulation,
which
the
biomarker
of
disease.
Since
primary
reason
unknown,
there
no
targeted
treatment
at
moment,
but
ongoing
research
aims
to
slow
its
progression
by
managing
amyloid-beta
peptide
production
rather
than
symptomatic
improvement.
phytochemicals
been
demonstrated
possess
antioxidant,
anti-inflammatory,
neuroprotective
properties,
they
may
target
multiple
pathological
factors
can
reduce
risk
Curcumin,
phytochemical
found
in
turmeric
known
for
free
radical
scavenging
an
antiamyloid
treating
AD,
has
come
under
investigation.
Although
low
bioavailability
limits
efficacy,
prominent
drug
delivery
system
(DDS)
desired
overcome
it.
Hence,
potency
lipid-based
nanoparticles
encapsulating
curcumin
(LNPs-CUR)
considered
this
study
promising
DDS.
In
vivo
studies
animal
models
indicate
LNPs-CUR
effectively
amyloid
plaque
formation,
leading
cognitive
enhancement
reduced
toxicity
compared
CUR.
However,
deeper
understanding
CUR's
pharmacokinetics
safety
profile
crucial
before
be
medicine.
Future
investigations
explore
combination
NPs
other
therapeutic
agents
increase
their
efficacy
cases.
This
review
provides
current
position
CUR
therapy
paradigm,
DDS
suggestions
CUR,
previous
point
analytical
view
focused
on
advantages
challenges.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(36), P. 14508 - 14515
Published: Aug. 23, 2024
An
ultrasensitive
self-powered
biosensor
is
constructed
for
miRNA-21
detection
based
on
Au
nanoparticles
@
Pd
nanorings
(Au
NPs@Pd
NRs)
and
catalytic
hairpin
assembly
(CHA).
The
NRs
possess
excellent
electrical
conductivity
to
improve
the
electron
transfer
rate
show
good
elimination
of
byproduct
H2O2
assist
glucose
oxidase
(GOD)
catalyze
glucose;
CHA
used
as
an
amplification
strategy
effectively
enhance
sensitivity
biosensor.
To
further
amplify
output
signal,
a
capacitor
integrated
into
With
multiple
signal
strategies,
possesses
linear
range
0.1–10–4
fM
lower
limit
(LOD)
0.032
(S/N
=
3).
In
addition,
as-prepared
displays
potential
applicability
in
assay
toward
human
serum
samples.
Archivos de Bronconeumología,
Journal Year:
2023,
Volume and Issue:
59(10), P. 629 - 637
Published: July 9, 2023
There
is
still
a
debate
for
the
link
between
obstructive
sleep
apnoea
(OSA)
and
cancer.
The
mechanisms
underlying
this
causality
are
poorly
understood.
Several
miRNAs
involved
in
cancer
development
progression
with
expression
being
influenced
by
hypoxia.
aims
of
work
were
(i)
to
compare
controls
versus
patients
affected
OSA
without
or
(ONCO-OSA)
(ii)
colorectal
cells
exposed
intermittent
hypoxia
(IH),
evaluate
impact
on
tumor
vitro.We
detected
qRT-PCR
patients'
sera
CaCo2
2-32h
IH
acriflavine
(ACF),
HIF-1
inhibitor.
Viability
transwell
invasion
test
applied
investigate
proliferation
migration
treated
miRNA
inhibitors
acriflavine.
HIF-1α
activity
was
evaluated
after
IH.The
levels
miR-21,
miR-26a
miR-210
increased
ONCO-OSA
compared
controls.
MiR-23b
patients,
miR-27b
miR-145
but
not
patients.
MiR-21,
miR-26a,
miR-23b
IH.
stimulated
cell
migration.
This
effect
reduced
either
inhibition
treatment.
MiRNA
reduces
gene
expression.
Conversely,
these
miRNAs.We
identified
signature
miRNAs,
induced
environment.
They
could
be
implicated
through
regulatory
loop
involving
HIF-1.
Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(5), P. 871 - 871
Published: May 22, 2023
In
this
study,
we
conducted
a
systematic
review
and
meta-analysis
to
summarize
evaluate
the
global
research
potential
of
different
circulating
miRNAs
as
an
early
diagnostic
biomarker
for
OC.
A
literature
search
relevant
studies
was
in
June
2020
followed
up
November
2021.
The
English
databases
(PubMed,
ScienceDirect).
primary
resulted
total
1887
articles,
which
were
screened
according
prior
established
inclusion
exclusion
criteria.
We
identified
44
studies,
22
eligible
quantitative
meta-analysis.
Statistical
analysis
performed
using
Meta-package
Rstudio.
Standardized
mean
differences
(SMD)
relative
levels
between
control
subjects
OC
patients
used
differential
expression.
All
quality
evaluated
Newcastle-Ottawa
Scale.
Based
on
meta-analysis,
nine
dysregulated
compared
controls.
Nine
upregulated
controls
(miR-21,
-125,
-141,
-145,
-205,
-328,
-200a,
-200b,
-200c).
Furthermore,
miR-26,
-93,
-106
-200a
analyzed,
but
did
not
present
overall
significant
difference
These
observations
should
be
considered
when
performing
future
relation
OC:
sufficient
size
clinical
cohorts,
development
consensus
guidelines
miRNA
measurements,
coverage
previously
reported
miRNAs.
GeroScience,
Journal Year:
2024,
Volume and Issue:
46(6), P. 6641 - 6657
Published: July 2, 2024
Abstract
Canine
mammary
tumors
(CMTs)
represent
a
significant
health
concern
in
dogs,
with
high
incidence
among
intact
female
dogs.
CMTs
are
promising
comparative
model
for
human
breast
cancer,
due
to
sharing
several
pathophysiological
features.
Additionally,
have
strong
genetic
correlation
their
counterpart,
including
the
expression
of
microRNAs
(miRNAs).
MiRNAs
class
non-coding
RNAs
that
play
important
roles
post-translational
regulation
gene
expression,
being
implicated
carcinogenesis,
tumor
progression,
and
metastasis.
Moreover,
miRNAs
hold
promise
as
diagnostic,
prognostic,
metastatic
biomarkers.
Understanding
molecular
mechanisms
underlying
is
crucial
improving
diagnosis,
prognosis,
monitoring
treatments.
Herein,
we
provide
comprehensive
overview
current
knowledge
on
CMTs,
highlighting
carcinogenesis
potential
highlight
limitations
critically
discuss
overarching
challenges
this
field,
emphasizing
need
future
research
translate
miRNA
findings
into
veterinary
clinical
practice.
