Exposure to irregular microplastic shed from baby bottles activates the ROS/NLRP3/Caspase-1 signaling pathway, causing intestinal inflammation

Environment International, Journal Year: 2023, Volume and Issue: 181, P. 108296 - 108296

Published: Oct. 30, 2023

Irregularly shaped microplastics (MPs) released from infant feeding bottles (PP-IFBs) may exhibit increased cytotoxicity, in contrast to the commonly studied spherical MPs. This study presents an initial analysis of thermal-oxidative aging process plastic shedding bottles, and investigates inflammatory response induced by these atypical MPs human intestinal cells (Caco-2). The PP-IFBs' surface displayed non-uniform white patches roughness, revealing substantial structural alteration shedding, especially during actions such as shaking, boiling water disinfection, microwave heating. FT-IR 2D-COS analyses revealed that oxygen targeted C-H C-C bonds polypropylene molecular chain, producing RO· ·OH, thereby hastening degradation. When were exposed PP-IFBs, oxidative stress was triggered, resulting lowered glutathione levels, augmented reactive species (ROS), heightened lipid peroxidation. Elevated levels pro-inflammatory cytokines (IL-6 TNFα) signified active process. notably more intense when through disinfection heating treatments, primarily due larger quantity their higher proportion smaller particles. Furthermore, NLRP3 inflammasome identified critical initiating this chain reaction mitochondrial ROS surge caused exposure. further validated inhibitor studies, emphasizing role ROS/NLRP3/Caspase-1/IL-1β signaling pathway promoting inflammation. Therefore, swift are recommended protect infants against potential health effects

Language: Английский

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Role of Uremic Toxins, Oxidative Stress, and Renal Fibrosis in Chronic Kidney Disease

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 687 - 687

Published: June 3, 2024

Affecting millions of people worldwide, chronic kidney disease is a serious medical problem. It results in decrease glomerular filtration rate below 60 mL/min/1.73 m, albuminuria, abnormalities urine sediment and pathologies detected by imaging studies lasting minimum 3 months. Patients with CKD develop uremia, as result the accumulation uremic toxins body, patients can be expected to suffer from number consequences such progression renal fibrosis, development atherosclerosis or increased incidence cardiovascular events. Another key element pathogenesis oxidative stress, resulting an imbalance between production antioxidants reactive oxygen species. Oxidative stress contributes damage cellular proteins, lipids DNA increases inflammation, perpetuating dysfunction. Additionally, fibrogenesis involving fibrous tissue kidneys occurs. In our review, we also included examples forms therapy for CKD. To improve condition patients, pharmacotherapy used, described review. Among drugs that prognosis CKD, include: GLP-1 analogues, SGLT2 inhibitors, Finerenone monoclonal antibody—Canakinumab Sacubitril/Valsartan.

Language: Английский

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Limosilactobacillus fermentum Strains as Novel Probiotic Candidates to Promote Host Health Benefits and Development of Biotherapeutics: A Comprehensive Review

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: 16(4), P. 1483 - 1498

Published: Feb. 23, 2024

Language: Английский

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Mercury(II)-Triggered Targeted and NIR-II Fluorescence/Photoacoustic Imaging Probe for High-Sensitivity Early Diagnosis and Evaluating Drug against Acute Liver and Kidney Injury

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Mercury ions (Hg2+) have been found to disrupt the body's antioxidant defense mechanisms, leading oxidative stress and physiological dysfunction. Early diagnosis real-time monitoring of Hg2+ fluctuations in organ damage are crucial but limited due lack noninvasive deep tissue imaging probes. Herein, a Hg2+-triggered targeted NIR-II fluorescence/photoacoustic (PA) dual-mode molecular probe (NHG-2) was developed for Hg2+-induced acute liver kidney injury mice. NHG-2 designed through rational adjustment conjugated ring structure further screening processes, enabling it sensitively recognize subsequently open mitochondrial targeting, producing fluorescence/PA signals. This allowed injury, demonstrating excellent detection sensitivity. Furthermore, can be utilized evaluate efficacy N-acetylcysteine (NAC) dual signal indication. Mechanism studies suggested that NAC activated Akt/Nrf2 signaling pathway, reversed changes related biomarkers, restored membrane potential. Thus, this study not only presents first specific also provides potential tool early treatment evaluation pathogenesis study.

Language: Английский

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Adenine-induced animal model of chronic kidney disease: current applications and future perspectives

Renal Failure, Journal Year: 2024, Volume and Issue: 46(1)

Published: April 4, 2024

Chronic kidney disease (CKD) with high morbidity and mortality all over the world is characterized by decreased function, a condition which can result from numerous risk factors, including diabetes, hypertension obesity. Despite significant advances in our understanding of pathogenesis CKD, there are still no treatments that effectively combat underscores urgent need for further study into pathological mechanisms underlying this condition. In regard, animal models CKD indispensable. This article reviews widely used model induced adenine. While physiologic dose adenine beneficial terms biological activity, known to induce renal organism. Following brief description procedure induction adenine, major adenine-induced then reviewed, inflammation, oxidative stress, programmed cell death, metabolic disorders, fibrillation. Finally, application future perspective as platform testing efficacy variety therapeutic approaches also discussed. Given simplicity reproducibility model, it remains valuable tool studying identifying targets fight CKD.

Language: Английский

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Insights into the Role of Glutathione Peroxidase 3 in Non-Neoplastic Diseases

Biomolecules, Journal Year: 2024, Volume and Issue: 14(6), P. 689 - 689

Published: June 13, 2024

Reactive oxygen species (ROSs) are byproducts of normal cellular metabolism and play pivotal roles in various physiological processes. Disruptions the balance between ROS levels body’s antioxidant defenses can lead to development numerous diseases. Glutathione peroxidase 3 (GPX3), a key component system, is an oxidoreductase enzyme. GPX3 mitigates oxidative damage by catalyzing conversion hydrogen peroxide into water. Beyond its function, vital regulating metabolism, modulating cell growth, inducing apoptosis facilitating signal transduction. It also serves as significant tumor suppressor cancers. Recent studies have revealed aberrant expression several non-neoplastic diseases, associating it with multiple pathological This review synthesizes current understanding regulation, highlighting extensive noncancerous Additionally, this paper evaluates potential diagnostic biomarker explores emerging therapeutic strategies targeting enzyme, offering avenues for future clinical treatment conditions.

Language: Английский

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Calcium signaling crosstalk between the endoplasmic reticulum and mitochondria, a new drug development strategies of kidney diseases

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 225, P. 116278 - 116278

Published: May 11, 2024

Language: Английский

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Progress in the application of novel inflammatory indicators in chronic kidney disease

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 30, 2025

Chronic kidney disease has become a public health problem endangering the of all humans because its high prevalence, mortality and medical burden. The chronic micro-inflammatory state is recognized as significant component CKD, playing key role in progression. Intervening inflammation during course can enhance prognosis. Recent studies have demonstrated that novel inflammatory indices, such neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte systemic immune-inflammatory index are closely associated with meanwhile may serve prognostic monitors all-cause death poor renal prognosis for disease. This article comprehensively reports on mechanisms micro-inflammation relationship between indicators their impact

Language: Английский

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The Role and Mechanism of Gut Microbiota in the Development of Diabetic Nephropathy

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(02), P. 215 - 222

Published: Jan. 1, 2025

Language: Английский

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Unveiling the antiurolithiatic potentiality of two benzene sulfonamide derivatives against ethylene glycol-induced renal calculi

Nefrología (English Edition), Journal Year: 2025, Volume and Issue: 45(2), P. 167 - 181

Published: Feb. 1, 2025

Oxidative stress and inflammation play crucial roles in the onset of kidney injury crystal formation caused by hyperoxaluria. Indapamide is a potent medication for treating renal calculi, but it has severe side effects such as hypokalemia, hypercalcemia, hyperuricemia. Therefore, advisable to explore alternative treatments that do not have these effects. The study aimed reveal antiurolithiatic potential two benzene sulfonamide derivatives (SBCl SBF; A B, respectively) against ethylene glycol-induced stones. rats were divided into main groups: first group consisted 20 with induced stones, second included 15 control rats. This division enabled comparative analysis between stones those without, offering insights stone induction on various physiological parameters biochemical markers. effectiveness (compounds B) was assessed treatment given orally gavage 21 days, administered every 48h after inducing 0.12ml 5% glycol (EG). influence compounds B electrolytes, biochemical, antioxidant, inflammatory reactions kidneys underscores their therapeutic advantages alleviating advancement disease related complications. Both found possess equal inhibiting complications formation. However, SBCl-EG showed superior antioxidant compared SBF-EG. Our study's findings underscore benefits nephrolithiasis oxidative disorders, highlighting responses standard treatments.

Language: Английский

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