IEEE Sensors Journal, Journal Year: 2024, Volume and Issue: 24(21), P. 35599 - 35609
Published: July 16, 2024
Language: Английский
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 24, 2025
Microplastics, as an emerging environmental pollutant, have received widespread attention for their potential impact on ecosystems and human health. Microplastics are defined plastic particles less than 5 millimeters in diameter can be categorized primary secondary microplastics. Primary microplastics usually originate directly from industrial production, while formed by the degradation of larger items. capable triggering cytotoxicity chronic inflammation, may promote cancer through mechanisms such pro-inflammatory responses, oxidative stress endocrine disruption. In addition, improved bring new perspectives to therapy, studies drug carriers underway, showing high targeting bioavailability. Although current suggest association between certain cancers (e.g., lung, liver, breast cancers), long-term effects specific still need studied. This review aimed at exploring carcinogenicity promising applications therapy provides important directions future research emphasizes multidisciplinary collaboration address this global health challenge.
Language: Английский
Citations
2
Toxics, Journal Year: 2024, Volume and Issue: 12(3), P. 178 - 178
Published: Feb. 26, 2024
The escalating prevalence of microplastics and nanoplastics in aquatic environments is a major challenge affecting the behavior reproductive health organisms while posing potential risks to human ecosystems. This review focuses on neurobehavioral changes toxicity MNPs zebrafish their relationships. At same time, caused by were studied, synergistic effects interaction these pollutants with other environmental contaminants explored. In addition, zebrafish, as model organism, provide valuable insights into subtle but important behavior, which critical for understanding success, suggesting that behavioral can serve an early biomarker toxicity. based classical endocrine disruptor models research methods, current status was reviewed, further indicated parameters be used effective rapid tool evaluate MNPs. However, methods rapidly assessing are still area exploration. To address limitations challenges scope research, this outlines future directions aim improving our impacts work aims inform targeted policies advance public strategies growing pollution.
Language: Английский
Citations
14
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 931, P. 172899 - 172899
Published: April 30, 2024
Language: Английский
Citations
11
Russian Chemical Reviews, Journal Year: 2025, Volume and Issue: 94(3), P. RCR5155 - RCR5155
Published: March 1, 2025
The presence of microplastics (MPs) in the environment is a highly relevant and aggravating environmental problem, which concern not only for specialists various fields but also everyone who cares about future Earth. ever-increasing production polymers expanding use plastic products enlarged MP concentrations Earth's ecosystem. need to control accumulation spread MPs caused by current crisis where no microplastic-free areas have remained on number studies dealing with existing potential threat living organisms from consumption increasing every year. aim this review systematize available information occurrence briefly describe main types polymer materials acting as sources mechanisms formation transport environment. hazardous behaviour analyzed considering their impact physiology aquatic soil organisms. Special emphasis demonstrating adverse effect emissions 3D printing materials. An overview methods capture given facilitate analysis development more reliable removal disposal. As result review, we assess long-term human health consequences exposure. Understanding formation, lifecycle environment, ways interaction will controlling design implementation effective techniques remediation prevent ecological consequences. <br>The bibliography includes 244 references.
Language: Английский
Citations
1
Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
Aged micro(nano)plastics (MNPs) are normally the ultimate state of plastics in environment after aging. The changes physical and chemical characteristics aged MNPs significantly influence their environmental behavior by releasing additives, forming byproducts, adsorbing contaminants. However, a systematic review is lacking on effects ecological human health regarding increasing but scattered studies results. This Review first summarizes unique methods for quantifying aging degree. Then we focused potential impacts organisms, ecosystems, health, including "Trojan horse" under real conditions. Through combining meta-analysis analytic hierarchy process (AHP) model, demonstrated that, compared to virgin MNPs, would result biomass decrease oxidative stress increase organisms lead total N/P greenhouse gas emissions ecosystems while causing cell apoptosis, antioxidant system reaction, inflammation health. Within framework risk assessment, used quotient (RQ) physiologically based pharmacokinetic (PBK) models as examples illustrate importance considering degree data acquisition, model building, formula evaluation. Given risks our urgent call more understand hazards real-world environments.
Language: Английский
Citations
1
Brain Sciences, Journal Year: 2024, Volume and Issue: 14(5), P. 471 - 471
Published: May 7, 2024
Plastic production, which exceeds one million tons per year, is of global concern. The constituent low-density polymers enable spread over large distances and micro/nano particles (MNPLs) induce organ toxicity via digestion, inhalation, skin contact. Particles have been documented in all human tissues including breast milk. MNPLs, especially weathered particles, can breach the blood–brain barrier, inducing neurotoxicity. This has non-human species, human-induced pluripotent stem cell lines. Within brain, MNPLs initiate an inflammatory response with pro-inflammatory cytokine oxidative stress generation reactive oxygen mitochondrial dysfunction. Glutamate GABA neurotransmitter dysfunction also ensues alteration excitatory/inhibitory balance favor reduced inhibition resultant neuro-excitation. Inflammation cortical hyperexcitability are key abnormalities involved pathogenic cascade amyotrophic lateral sclerosis (ALS) intricately related to mislocalization aggregation TDP-43, a hallmark ALS. Water many foods contain humans, ingestion main form exposure. Digestion plastics within gut alter their properties, rendering them more toxic, they cause microbiome dysbiosis dysfunctional gut–brain axis. recognized as trigger and/or aggravating factor for ALS associated long (years or decades) preclinical period neonates infants exposed through milk, milk substitutes, toys. endangers time intense neurogenesis establishment neuronal circuitry, setting stage development neurodegeneration later life. MNPL neurotoxicity should be considered yet unrecognized risk diseases.
Language: Английский
Citations
6
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Oct. 22, 2024
The presence of microplastics within the human body has raised significant concerns about their potential health implications. Numerous studies have supported hypothesis that accumulation can trigger inflammatory responses, disrupt microbiome, and provoke immune reactions due to physicochemical properties. Chronic inflammation, characterized by tissue damage, angiogenesis, fibrosis, plays a crucial role in cancer development. It influences progression altering tumor microenvironment impairing surveillance, thus promoting tumorigenesis metastasis. This review explores fundamental properties bioaccumulation microplastics, as well transition from chronic inflammation carcinogenesis. Additionally, it provides comprehensive overview associated alterations signaling pathways, microbiota disturbances, responses. Despite this, current understanding toxicity biological impacts remains limited. To mitigate harmful effects on health, there is an urgent need improve detection removal methods for necessitating further research elucidation.
Language: Английский
Citations
6
Life, Journal Year: 2024, Volume and Issue: 14(3), P. 371 - 371
Published: March 12, 2024
Microplastics are small plastic pieces with sizes less than 5 mm. They becoming a global concern due to the potential risk human health. The risks of microplastics may be greater for infants because they do not have sufficiently developed metabolizing enzymes, ability remove microplastics, and highly sensitive target organs. Infants should breastfed first six months life. Breast milk is considered most complete suitable source nutrition. However, if breastfeeding during this period possible, it necessary use formulas designed infant initial feeding. exposed higher levels MPs through foods or products. aim study describe possible sources exposure such as placenta, feeding bottles, toys well presence released in feces, breast milk, formulas. There still enough data available area. Therefore, pay increased attention minimizing negative effects on
Language: Английский
Citations
5
Mucosal Immunology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Mitochondria are key regulators of inflammatory responses and mitochondrial dysfunction is closely linked to various diseases. Increasing genetic experimental evidence suggests that mitochondria play a critical role in bowel disease (IBD). In the complex environment intestinal tract, epithelial cells (IECs) their possess unique phenotypic features, shaping each other regulating homeostasis inflammation through diverse mechanisms. Here, we focus on IBD induced by damage-associated molecular patterns (mtDAMPs), which comprise components metabolic products. The pathogenic mechanisms mtDAMP signaling pathways mediated two major mtDAMPs, DNA (mtDNA) reactive oxygen species (mtROS), discussed.
Language: Английский
Citations
0
Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137704 - 137704
Published: Feb. 20, 2025
Language: Английский
Citations
0