Causal association of inflammatory bowel disease with sarcoidosis and the mediating role of primary biliary cholangitis DOI Creative Commons

Jiazhi Yi,

Shuyun Wu,

Hongxia He

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 3, 2024

Objectives Previous observational epidemiological studies have identified a potential association between inflammatory bowel disease (IBD) and sarcoidosis. Nonetheless, the precise biological mechanisms underlying this remain unclear. Therefore, we adopted Mendelian randomization (MR) approach to investigate causal relationship IBD with genetic susceptibility sarcoidosis, as well explore mediating role. Methods The associations were obtained from publicly available genome-wide (GWASs) of European ancestry. dataset has 31,665 cases 33,977 controls, consisting 13,768 individuals ulcerative colitis (UC) 17,897 Crohn’s (CD). sarcoidosis 4,854 446,523 controls. A bidirectional causality was implemented be determined by two-sample MR approach. inverse variance weighted (IVW) method utilized main statistical method, series sensitivity analyses performed detect heterogeneity horizontal pleiotropy. two-step used whether pathway mediated PBC. Results forward analysis indicated that predisposition significantly linked an increased risk (OR = 1.088, 95% CI: 1.023–1.158, p IBD-sar 7.498e-03). Similar observed in CD 1.082, 1.028–1.138, CD-sar 2.397e-03) UC 1.079, 1.006–1.158, UC-sar 0.034). Reverse revealed correlated augmented 1.306, 1.110–1.537, sar-CD 1.290e-03) but not or UC. mediation via showed influence on effects partly PBC, effect 0.018 (95% 0.005–0.031, 7.596e-03) proportion 21.397% IBD, 0.014 0.004–0.024, 7.800e-03) 17.737% CD. Conclusions provided evidence substantiating (CD UC) PBC playing role However, only enhances developing CD, These findings illuminate etiology contribute management patients.

Language: Английский

The Pharmacological Efficacy of Baicalin in Inflammatory Diseases DOI Open Access
Yongqiang Wen, Shaobin Wang, Chenxu Zhao

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9317 - 9317

Published: May 26, 2023

Baicalin is one of the most abundant flavonoids found in dried roots Scutellaria baicalensis Georgi (SBG) belonging to genus Scutellaria. While baicalin demonstrated have anti-inflammatory, antiviral, antitumor, antibacterial, anticonvulsant, antioxidant, hepatoprotective, and neuroprotective effects, its low hydrophilicity lipophilicity limit bioavailability pharmacological functions. Therefore, an in-depth study baicalin’s pharmacokinetics contributes laying theoretical foundation for applied research disease treatment. In this view, physicochemical properties anti-inflammatory activity are summarized terms bioavailability, drug interaction, inflammatory conditions.

Language: Английский

Citations

61
Gegen Qinlian decoction ameliorates TNBS-induced ulcerative colitis by regulating Th2/Th1 and Tregs/Th17 cells balance, inhibiting NLRP3 inflammasome activation and reshaping gut microbiota DOI

Yingnan Hu,

Jingyi Tang,

Yongfeng Xie

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 328, P. 117956 - 117956

Published: Feb. 29, 2024

Language: Английский

Citations

19
CCR2 signaling regulates anti-chlamydia T cell immune responses in the airway DOI Creative Commons

Shuaini Yang,

Jinxi Yu,

Xue Dong

et al.

PLoS Pathogens, Journal Year: 2025, Volume and Issue: 21(2), P. e1012912 - e1012912

Published: Feb. 4, 2025

CCR2, a member of the G protein-coupled receptor (GPCR) superfamily, is widely expressed on monocytes, macrophages, activated T cells, and other cell types, plays critical role in coordinating immune response to various infections. Here we demonstrate that CCR2 expression significantly elevated during Chlamydia muridarum ( C . ) respiratory infection, its absence leads exacerbated susceptibility, as evidenced by significant weight loss, higher bacterial loads, severe lung pathology, levels inflammatory cytokines il-1β , tnfα il-6 ). The ccr2 impairs both myeloid infiltration responses, which are crucial for effective defense. Specifically, deficiency disrupts differentiation Th1 primary effector lineage responsible clearing chlamydia through secretion interferon-gamma (IFN-γ). As result, there decrease CD3 + CD4 IFN-γ cells spleen, accompanied reduced protein mRNA, well downregulated mRNA Th1-promoting il-12p35 il-12p40 transcription factors stat4 T-bet ), play roles differentiation. Moreover, greatly diminishes STAT1 phosphorylation, key regulator cells. Meanwhile, also observed reduction CD8 following deficiency. Conversely, -/- mice exhibit an exaggerated Th2-type response, with Th2-promoting (IL-4), (STAT6 gata3 il-5 together lead more tissue damage increased susceptibility infection. Furthermore, these show IL-17 along enhanced Th17-type characterized Th17-promoting TGFB stat3 RORγt il-21 suggesting compensatory mechanism drives neutrophil exacerbate inflammation. These findings underscore pivotal chemokine receptor, orchestrating infection facilitating while restraining thereby alleviating pulmonary

Language: Английский

Citations

1
Astragalus polysaccharide attenuates nonalcoholic fatty liver disease through THDCA in high-fat diet-fed mice DOI
Ningning Zheng, Hao Wang, Weize Zhu

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 320, P. 117401 - 117401

Published: Nov. 13, 2023

Language: Английский

Citations

19
mTOR promotes an inflammatory response through the HIF1 signaling pathway in ulcerative colitis DOI Creative Commons
Y Wang, Ming Li,

Ansheng Zha

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 134, P. 112217 - 112217

Published: May 7, 2024

The imbalance between T helper cell 17 (Th17)and regulatory cells (Treg) leading to inflammation has an important role in the pathogenesis of ulcerative colitis (UC). Mammalian target rapamycin (mTOR) can regulate differentiation cells, but specific pathway mTOR Th17/Treg UC remains unclear. Our aim with this study was investigate effects overexpression and silencing on hypoxia inducible factor-1α (HIF-1α) − signaling pathway. To mimic a human study, we established colon cancer epithelial line (HT-29) co-culture system CD4+ treated TNF-α. We observed HIF-Th17/Treg determine whether is involved mechanism. Under stimulation TNF-α, levels HIF-1α CD4+T were increased HT-29 promoting glycolysis, increasing Th17 proportion, decreasing Treg pro-inflammatory factors levels, anti-inflammatory levels. Moreover, after silencing, level glycolysis decreased, factor increased. In contrast, lead opposite results.mTOR promotes by regulating HIF during UC, may alleviate inflammation. An inhibitor potential therapeutic for treatment.

Language: Английский

Citations

8
Bile acids and their receptors: Potential therapeutic targets in inflammatory bowel disease DOI Creative Commons

Xiong-Quan Long,

Ming‐Zhu Liu,

Zi-Hao Liu

et al.

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(27), P. 4252 - 4270

Published: July 13, 2023

Chronic and recurrent inflammatory disorders of the gastrointestinal tract caused by a complex interplay between genetics intestinal dysbiosis are called bowel disease. As result interaction liver gut microbiota, bile acids an atypical class steroids produced in mammals traditionally known for their function food absorption. With development genomics metabolomics, more data suggest that pathophysiological mechanisms disease regulated receptors. Bile operate as signalling molecules activating variety acid receptors impact flora, epithelial barrier function, immunology. Inflammatory can be treated new ways using these potential molecules. This paper mainly discusses increasing prospective therapeutic applications. In addition, we explore metabolism microbiota.

Language: Английский

Citations

14
Adjuvanted quaternized chitosan composite aluminum nanoparticles-based vaccine formulation promotes immune responses in chickens DOI
Jiali Liu,

Sihan Guo,

Zheng Jin

et al.

Vaccine, Journal Year: 2023, Volume and Issue: 41(18), P. 2982 - 2989

Published: April 7, 2023

Language: Английский

Citations

12
Ginsenoside Rg1 Alleviates Ulcerative Colitis in Obese Mice by Regulating the Gut Microbiota–Lipid Metabolism–Th1/Th2/Th17 Cells Axis DOI
Youbao Zhong,

Qiuping Xiao,

Jiaqi Huang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(50), P. 20073 - 20091

Published: Dec. 8, 2023

Ginsenoside Rg1 (G-Rg1) has various pharmacological properties including antiobesity, immunomodulatory, and anti-inflammatory effects. This study aimed to explore the therapeutic effects underlying mechanisms of G-Rg1 on colitis complicated by obesity. The results indicate that effectively alleviates in obese mice improves serum lipid levels liver function. Importantly, improved composition gut microbiota with colitis, increases alpha diversity indexes Sobs, Ace, Chao, a significant down-regulation relative abundance Romboutsia, up-regulation Rikenellaceae_RC9_gut_group, Lachnospiraceae_NK4A136_group, Enterorhabdus, Desulfovibrio, Alistipes. Meanwhile, metabolism colonic contents colitis. Additionally, significantly reduced percentages helper T (Th)1, Th17, central memory (TCM), effector (TEM) cells while increasing Naïve Th2 cells. In conclusion, could be promising option for alleviating obesity through regulation as well Th1/Th2/Th17 cell differentiation.

Language: Английский

Citations

12
Goose Deoxycholic Acid Ameliorates Liver Injury in Laying Hens with Fatty Liver Hemorrhage Syndrome by Inhibiting the Inflammatory Response DOI Open Access
Nannan Wang, Weiwei Li,

Guangyi Ouyang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 429 - 429

Published: Jan. 6, 2025

Fatty liver hemorrhagic syndrome (FLHS) in laying hens is a nutritional and metabolic disease involving enlargement, hepatic steatosis, hemorrhage as the primary symptoms. The prone to occur during peak period of hens, which has resulted significant economic losses hen breeding industry; however, specific pathogenesis FLHS remains unclear. Our group previous studies have shown that bile acid levels are significantly decreased development fatty targeted activation acid–related signaling pathways beneficial for preventing treating liver. In this study, we generated model by feeding high-energy, low-protein diet, with goose deoxycholic (CDCA) given an intervention. HE staining, fluorescence quantitative PCR, ELISA were used evaluate effects CDCA on pathological changes inflammatory responses results showed was reduced after treatment. Furthermore, fat vacuoles transaminase significantly. addition, expression M1-type macrophage markers polarization products reduced, pro-inflammatory regulatory factors related JAK-STAT pathway, LPS-TLR4-Myd88–NF-kB NLRP3 inflammasomes well. Expression M2-type increased significantly, did anti-inflammatory regulators pathway. These suggest ameliorates injury inhibiting resulting response, thereby promoting response.

Language: Английский

Citations

0
Systematic druggable genome-wide Mendelian randomization to identify therapeutic targets and dominant flora for ulcerative colitis DOI Creative Commons
Haiya Ou,

Hongshu Huang,

Y. P. Xu

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107662 - 107662

Published: Feb. 1, 2025

The relationship and mechanism among gut microbiota (GM), metabolites active ulcerative colitis (UC) are unclear. This study aims to infer the causal between druggable-genes UC using Mendelian randomization (MR) bioinformatics methods. "microbiota-target" "microbiota- metabolite" network was constructed screen microorganisms associated with UC, of GM, active-UC analyzed. These findings were verified through molecular docking, dynamics (MD) simulations co-localization analysis. Subsequently, effects key GM targets on mice induced by dextran sulfate sodium (DSS) investigated. Our indicated that four drug (IFN-γ, IL24, CXCR6, PRKCZ) closely risk IL24 specifically found be colocalized UC. significantly correlated differences immune cell infiltration in active-UC. Faecalibacterium prausnitzii (F. prausnitzii) predicted inhibit IFN-γ promote remission Additionally, seven identified Molecular docking MD further confirmed stable interactions F. prausnitzii. We also alleviating effect DSS-induced mice. result can reduce inflammatory goblet death colon, lower myeloperoxidase activity, downregulate expression levels. revealed modify microenvironment providing new ideas for prevention treatment

Language: Английский

Citations

0