O uso irracional e prolongado de benzodiazepínicos como potenciais causadores de demência em idosos DOI Creative Commons

LARISSA MARCHI,

Luís Fernando Piovesan,

Dallila Brandão dos Santos Bianchi

et al.

Revista Master Ensino Pesquisa e Extensão, Journal Year: 2023, Volume and Issue: 8(16)

Published: Dec. 14, 2023

Introdução: Os benzodiazepínicos são as drogas psiquiátricas mais utilizadas em todo o mundo possuindo propriedades farmacológicas com efeitos sedativos, hipnóticos, ansiolíticos, anticonvulsivantes e relaxantes musculares. No entanto uso prolongado pode estar associado à demência, sobretudo entre os idosos. Objetivo: Investigar a associação demência de Materiais Métodos: Foi feita uma revisão bibliográfica caráter narrativo dos artigos publicados nos últimos dez anos (2013 2023), utilizando bases dados SciELO, PubMed, BVS Google Acadêmico. Resultados: O estudo das bibliografias selecionadas mostrou que idosos tem alta prevalência. Além disso, essa classe medicamentos não é recomendada para por idosos, agravando suas consequências ainda quando tratamento realizado longo prazo, exacerbando série eventos adversos sem apresentar eficácia nesse formato uso. Grande parte estudos fármacoepidemiológicos realizados até momento concluíram usuários apresentam maior risco desenvolver mas permanecem obscuros mecanismos pelos quais possivelmente ocorre aumento do Conclusão: É importante buscar formas menos prejudiciais sanar queixas relação sono ansiedade capacitar profissionais saúde, fim identificar recomendado propor otimizar prescrições. Portanto, há necessidade aprofundados sobre assunto, observar possíveis riscos existentes no irracional benzodiazepínicos.

The potential role of brain renin‐angiotensin system in the neuropathology of Parkinson disease: Friend, foe or turncoat? DOI Creative Commons
Zainah Al‐Qahtani, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(12)

Published: June 1, 2024

Abstract Parkinson disease (PD) is one of the most common neurodegenerative diseases brain. Of note, brain renin‐angiotensin system (RAS) intricate in PD neuropathology through modulation oxidative stress, mitochondrial dysfunction and neuroinflammation. Therefore, RAS by angiotensin receptor blockers (ARBs) angiotensin‐converting enzyme inhibitors (ACEIs) may be effective reducing risk neuropathology. It has been shown that all components including peptides enzymes are present different areas. Brain plays a critical role regulation memory cognitive function, controlling central blood pressure. However, exaggerated implicated pathogenesis PD. Two well‐known pathways recognized including; classical pathway which mainly mediated AngII/AT1R detrimental effects. Conversely, non‐classical mostly ACE2/Ang1‐7/MASR AngII/AT2R beneficial effects against Exaggerated affects viability dopaminergic neurons. fundamental mechanism was not fully elucidated. Consequently, purpose this review to disclose mechanistic In addition, we try revise how ACEIs ARBs can developed for therapeutics

Language: Английский

Citations

7
Impaired sleep is associated with tau deposition on 18F-flortaucipir PET and accelerated cognitive decline, accounting for medications that affect sleep DOI
Ryan T. Kim, Liangdong Zhou, Yi Li

et al.

Journal of the Neurological Sciences, Journal Year: 2024, Volume and Issue: 458, P. 122927 - 122927

Published: Feb. 8, 2024

Language: Английский

Citations

4
Dual orexin receptor antagonists as promising therapeutics for Alzheimer’s disease DOI Creative Commons

Sydney M. Ragsdale,

John M. Radovich,

Isabel I. Coiduras

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: March 8, 2025

We examine the relationship between sleep, glymphatics and Alzheimer's disease (AD), recent work questioning glymphatic clearance during sleep. highlight a need for understanding and/or other mechanism of review flow measurement methods. Further, we explore dual orexin receptor antagonists (DORAs) potential to mitigate AD sleep disturbances enhance clearance. Further research could elucidate linkage DORAs, improved reducing pathophysiology.

Language: Английский

Citations

0
Unraveling the Immune Puzzle: Role of Immunomodulation in Alzheimer’s Disease DOI

Ashvin,

Rishika Dhapola,

Sneha Kumari

et al.

Journal of Neuroimmune Pharmacology, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 29, 2025

Language: Английский

Citations

0
Integrated network pharmacology and phosphoproteomic analyses of Baichanting in Parkinson's disease model mice DOI Creative Commons
Xin Gao, Jiaqi Fu, Donghua Yu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e26916 - e26916

Published: Feb. 27, 2024

The incidence rate of Parkinson's disease (PD) is increasing yearly. Neuronal apoptosis caused by abnormal protein phosphorylation closely related to the pathogenesis disease. At present, few PD-specific pathways have been revealed. To investigate effect Baichanting (BCT) on from perspective phosphorylation, α-syn transgenic mice were selected observe behavioral changes mice, and substantia nigra cells detected HE method TUNEL method. Network pharmacology combined with proteomics was used find relevant targets for BCT treatment PD further verified PRM western blotting. improved morphology neurons in reduced neuronal apoptosis. main enriched network results apoptosis, p53 signaling pathway autophagy. Western blot showed that significantly regulated expression levels BAX, Caspase-3, LC3B, P53 mTOR upregulated autophagy alleviate Using phosphorylated validation, we found Pak5, Grin2b, Scn1a, BcaN, L1cam Braf are correlated web-based pharmacological screen may be involved p53/mTOR-mediated pathways. can inhibit activation p53/mTOR pathway, thereby enhancing function cells, reducing which mechanism its neuroprotective effect.

Language: Английский

Citations

3
The neuroprotective role of Humanin in Alzheimer's disease: The molecular effects DOI Creative Commons
Saad Misfer Alqahtani, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177510 - 177510

Published: March 1, 2025

Humanin (HN) is an endogenous micropeptide also known as a mitochondria-derived peptide. It has neuroprotective effect against Alzheimer's disease (AD) and other neurodegenerative diseases by improving hippocampal acetylcholine attenuating the development of oxidative stress associated neurotoxicity. HN protects neuron from toxic effects amyloid beta (Aβ). regarded biomarker mitochondrial stress. Interestingly, aging reduces brain expression HN, leading to cognitive impairment elevating risk neurodegeneration, including AD. However, in old subjects AD patients, circulating levels increase compensatory mechanism reduce neurodegeneration dysfunction Conversely, studies demonstrated reduction These findings indicated controversial points regarding precise mechanistic role Therefore, aim this review was discuss exact neuropathology molecular mechanisms

Language: Английский

Citations

0
The neuroprotective effect of vitamin D in Parkinson's disease: association or causation DOI
Amin A. Hafiz

Nutritional Neuroscience, Journal Year: 2023, Volume and Issue: 27(8), P. 870 - 886

Published: Sept. 20, 2023

ABSTRACTParkinson's disease (PD) is a chronic neurodegenerative (NDD) due to the degeneration of dopaminergic neurons (DNs) in substantia nigra (SN). PD characterized by diverse motor symptoms such as rigidity, resting tremors, and bradykinesia, non-motor cognitive dysfunction sleep disturbances. Vitamin D (VD), VD receptor (VDR), metabolites are present brain play role maintaining development, differentiation, functions DNs. VDRs exert protective effects against neuropathology modulating functional capacity DNs neurotransmission SN. In virtue its anti-inflammatory antioxidant activities, could be effective prevention treatment PD. exerts neuroprotective effect reducing oxidative stress mitochondrial dysfunction, increasing autophagy brain-derived neurotrophic factor (BDNF). Low serum level connected with development dementia The VD-mediated augmenting interrelated safeguarding synaptic plasticity modulation neurotransmitter release. deficiency linked severity olfactory which precedes progression symptomatic However, precise remains unidentified, there conflict about whether can ameliorate or not.KEYWORDS: Parkinson's diseaseVitamin DVD receptorBDNFsubstantia nigraAutophagyOxidative stressdopaminergic AcknowledgementsNot applicable.Authors' contributionsAAH conceptualized manuscript, wrote, edited, reviewed main text approved final edition manuscript.Disclosure statementNo potential interest was reported author(s).Additional informationFundingThe author(s) no funding associated work featured this article.

Language: Английский

Citations

6
Hypoglycemia and Alzheimer Disease Risk: The Possible Role of Dasiglucagon DOI Creative Commons

Naif H. Ali,

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Cellular and Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 44(1)

Published: July 8, 2024

Abstract Alzheimer's disease (AD) is a progressive neurodegenerative characterized by memory impairment and cognitive dysfunctions. It has been shown that hypoglycemia can adversely affect AD neuropathology. well-known chronic hyperglycemia in type 2 diabetes (T2D) regarded as potential risk factor for the development progression of AD. However, effect recurrent on pathogenesis was not deeply discussed, how affects at cellular molecular levels intensely interpreted previous studies. The underlying mechanisms hypoglycaemia-induced are diverse such endothelial dysfunction, thrombosis, neuronal injury causing tau protein hyperphosphorylation accumulation amyloid beta (Aβ) brain neurons. Of note, glucagon hormone, which controls blood glucose, also regulate functions. Glucagon increases glucose antagonizing metabolic insulin. Therefore, glucagon, through attenuation hypoglycemia, may prevent Glucagon/GLP-1 to promote synaptogenesis, hippocampal synaptic plasticity, learning memory, while attenuating pathologies. activation receptors reduce A recent receptor agonist dasiglucagon used management be effective preventing This review aims discuss role treating AD, this drug

Language: Английский

Citations

1
Thyroid dysfunction and risk of different types of dementia: A systematic review and meta-analysis DOI Creative Commons
Jianbo Ye, Zhenxing Huang,

Chunfeng Liang

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(34), P. e39394 - e39394

Published: Aug. 23, 2024

Background: The impact of thyroid function on the risk various types dementia, including Alzheimer’s disease (AD) and vascular dementia (VD), remains unclear. This meta-analysis investigates association between dysfunction these types, aiming to inform strategies for prevention. Methods: A comprehensive search was conducted in PubMed, Embase, Cochrane Library studies published up February 2023, focusing dementia. We excluded duplicates, without full text, those with incomplete data, animal studies, case reports, reviews. Data analysis performed using STATA 15.1 software. Results: Our indicated that overt hyperthyroidism significantly increases all studied (OR = 1.18, 95% CI: 1.04–1.35). In contrast, hypothyroidism associated a decreased AD 0.73, 0.55–0.98) VD 0.71, 0.62–0.82). Subclinical also showed significant an increased any 1.26, 1.09–1.46) specifically 6.70; 1.38–32.58). Conclusion: study suggests may reduce VD, whereas subclinical are linked risk. These findings highlight importance monitoring as preventative measure against

Language: Английский

Citations

1
Role of Autophagy in Type 2 Diabetes Mellitus: The Metabolic Clash DOI Creative Commons
Yousef Abud Alanazi,

Haydar M. Al‐kuraishy,

Ali I. Al‐Gareeb

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(23)

Published: Dec. 1, 2024

Type 2 diabetes mellitus (T2DM) is developed due to the development of insulin resistance (IR) and pancreatic β cell dysfunction with subsequent hyperglycaemia. Hyperglycaemia-induced oxidative stress endoplasmic reticulum (ER) enhances inflammatory disorders, leading further dysfunction. These changes trigger autophagy activation, which recycles cytoplasmic components injured organelles. Autophagy regulates functions by different mechanisms. Though exact role in T2DM not completely elucidated, that could be beneficial or detrimental. Therefore, this review aims discuss pathogenesis T2DM.

Language: Английский

Citations

1