Effect of endothelial responses on sepsis-associated organ dysfunction DOI Creative Commons
Miao Wu, Yan Yan, Xinyu Xie

et al.

Chinese Medical Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract Sepsis-related organ dysfunction is associated with increased morbidity and mortality. Previous studies have found that the endothelium plays crucial roles in maintaining vascular permeability during sepsis, as well regulating inflammation thrombosis. During endothelial cells may release cytokines, chemokines, pro-coagulant factors, express adhesion molecules. In general, responses sepsis typically inhibit bacterial transmission coordinate leukocyte recruitment to promote clearance. However, excessive or prolonged activation can lead impaired microcirculation, tissue hypoperfusion, dysfunction. Given structural functional heterogeneity of different organs, there are potential differences by type, risk damage vary accordingly. This article reviews response observed its effects on function, summarizes current progress development therapeutic interventions targeting response, discusses future research directions serve a reference for researchers field.

Language: Английский

Astaxanthin treatment reduces kidney damage and facilitates antioxidant recovery in lithium-intoxicated rats DOI
Elif Erbaş, Hilal Üstündağ, Emre Öztürk

et al.

Toxicon, Journal Year: 2024, Volume and Issue: 241, P. 107664 - 107664

Published: March 8, 2024

Language: Английский

Citations

11
Investigating the individual and combined effects of coenzyme Q10 and vitamin C on CLP-induced cardiac injury in rats DOI Creative Commons
Hilal Üstündağ, Özlem Demir, Mehmet Tahir Huyut

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 7, 2024

Abstract Sepsis-induced cardiac injury represents a major clinical challenge, amplifying the urgency for effective therapeutic interventions. This study aimed to delve into individual and combined prophylactic effects of Vitamin C (Vit C) Coenzyme Q10 (CoQ10) against inflammatory heart in cecal ligation puncture (CLP) induced polymicrobial sepsis rat model. Thirty adult female Sprague–Dawley rats were randomly divided five groups: Control, CLP, C, CoQ10, Vit + each consisting six rats. Treatments administered orally via gavage 10 days prior operation. Eighteen hours post-sepsis induction, animals euthanized, specimens collected analysis. The examined variations oxidative (TOS, OSI, MDA, MPO) antioxidative markers (TAS, SOD, CAT, GSH), histopathological changes, cytokine concentrations (TNF-α, IL-1β), nitric oxide (NO) dynamics, indicators such as CK-MB. Impressively, regimen markedly diminished stress, parameters reflected notable enhancements. Elevated NO levels, central player sepsis-driven cascades, effectively tempered by our intervention. Histological examinations corroborated biochemical data, revealing tissue damage treated subjects. Furthermore, marked suppression pro-inflammatory cytokines was discerned, solidifying potential Interestingly, certain evaluations, CoQ10 exhibited superior benefits over C. Collectively, these findings underscore promise combination septic injuries

Language: Английский

Citations

7
Molecular mechanisms of resveratrol and its silver nanoparticle conjugate in addressing sepsis-induced lung injury DOI Creative Commons
Hilal Üstündağ, Adem Kara, Songül Doğanay

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(8), P. 6249 - 6261

Published: March 28, 2024

Sepsis is a life-threatening condition characterized by systemic inflammatory response to infection. Despite extensive research on its pathophysiology, effective therapeutic approaches remain challenge. This study investigated the potential of resveratrol (RV) and silver nanoparticle-enhanced (AgNP-RV) as treatments for sepsis-induced lung injury using rat model polymicrobial sepsis induced cecal ligation puncture (CLP). The focused evaluating changes in oxidative status (TAS, TOS, OSI) expression apoptotic markers (IL-1β, TNF-α, P2X7R, TLR4, Caspase-3, Bcl-2) tissue. Both RV AgNP-RV demonstrated mitigating stress, inflammation, apoptosis, with exhibiting greater efficacy than alone (p < 0.05). These findings were corroborated histopathological analyses, which revealed reduced tissue damage RV- AgNP-RV-treated groups. Our highlights and, particularly, combating apoptosis. It also underscores promise nanoparticle technology enhancing outcomes. However, further investigations are warranted fully understand mechanisms action, especially concerning role P2X7 receptor observed effects. Nonetheless, our suggests that hold novel strategies management.

Language: Английский

Citations

6
The role and therapeutic potential of SIRTs in sepsis DOI Creative Commons

Jiaqi You,

Yilin Li, Chong Wei

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 16, 2024

Sepsis is a life-threatening organ dysfunction caused by the host’s dysfunctional response to infection. Abnormal activation of immune system and disturbance energy metabolism play key role in development sepsis. In recent years, Sirtuins (SIRTs) family has been found an important pathogenesis SIRTs, as class histone deacetylases (HDACs), are widely involved cellular inflammation regulation, oxidative stress. The effects SIRTs on cells mainly reflected regulation inflammatory pathways. This helps balance may lessen cell damage terms metabolism, can immunophenotypic transformation regulating improve mitochondrial function, increase production, maintain balance. also regulate production reactive oxygen species (ROS), protecting from stress activating antioxidant defense pathways maintaining between oxidants reducing agents. Current studies have shown that several potential drugs, such Resveratrol melatonin, enhance activity SIRT. It help reduce response, stress, showing clinical application prospects for treatment review focuses SIRT cells, well its influence multiple sepsis, discusses summarizes related drugs compounds sepsis through pathway involving SIRTs. become new target resulting dysfunction, providing ideas possibilities this disease.

Language: Английский

Citations

5
Enhanced Efficacy of Resveratrol Loaded Silver Nanoparticle in Attenuating Sepsis-Induced Acute Liver Injury: Modulation of Inflammation, Oxidative Stress, and SIRT1 Activation DOI
Hilal Üstündağ, Ferdane Danışman Kalındemirtaş, Songül Doğanay

et al.

Shock, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 5, 2023

ABSTRACT Sepsis-induced acute liver injury is a life-threatening condition involving inflammation, oxidative stress, and endothelial dysfunction. In the present study, preventive effects of resveratrol (RV) alone resveratrol-loaded silver nanoparticles (AgNPs+RV) against sepsis-induced damage were investigated compared in rat model polymicrobial sepsis induced by cecal ligation puncture (CLP). Rats divided into four groups: Sham, CLP, RV, AgNPs+RV. Pro-inflammatory cytokines (tumor necrosis factor-alpha [TNF-α], interleukin-1 beta [IL-1β], interleukin-6 [IL-6]), nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB) activation, presepsin, procalcitonin, 8-hydroxy-2'-deoxyguanosine (8-OHDG), vascular growth (VEGF), Sirtuin-1 (SIRT-1) levels assessed to determine treatments' effects. AgNPs+RV treatment significantly reduced pro-inflammatory cytokines, NF-κB 8-OHDG, VEGF CLP group, indicating attenuation injury. Both RV treatments increased SIRT1 levels, suggesting potential role activation mediating protective conclusion, demonstrated extremely enhanced efficacy alleviating modulating dysfunction, potentially mediated through activation. this effect on was evaluated for first time these findings highlight as promising therapeutic strategy managing injury, warranting further investigation.

Language: Английский

Citations

11
The Potential Impacts of Antioxidant Micronutrients on Productive and Reproductive Performances of Mammalian Species during Stressful Conditions DOI Creative Commons
Abd El-Nasser Ahmed Mohammed, S. Al-Suwaiegh, I. AlGherair

et al.

Indian Journal of Animal Research, Journal Year: 2024, Volume and Issue: Of

Published: March 15, 2024

Background: The antioxidant micronutrients supplementation to mammalian species during stressful condition have gained great attention of nutritionists alleviate peri parturient factors, which negatively effect on productive and reproductive performances in subtropics. Methods: given refer minerals (copper, zinc selenium) vitamins (vitamins A, C E). balanced diet needs an adequate amount conditions for species. Result: are played pivotal roles body functions especially transitional period ruminants. They improve quality feed, cell functions, carbohydrates, protein metabolism. Changes animals’ production, reproduction therapeutic been confirmed over supplementations. change feed intake, nutrient digestibility, rumen fermentation energy production. Such increases digestibility growth performance resulted improvement oocyte, embryo fetus qualities. In addition, blood cells plasma biochemistry, immunity were altered due micronutrient supplementation. Hence, the review article was designed collect, consolidate discuss effects productive, ruminant

Language: Английский

Citations

4
Efficacy of melatonin as adjunctive therapy for sepsis: A Meta-Analysis of Randomized Controlled Trials DOI Creative Commons
Zhuangzhuang Sun, C. Yu,

Zhaopeng Zhang

et al.

Complementary Therapies in Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 103147 - 103147

Published: Feb. 1, 2025

Language: Английский

Citations

0
Melatonin Exerts Positive Effects on Sepsis Through Various Beneficial Mechanisms DOI Creative Commons
Jing Xu, Cui Liang, You Shang

et al.

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 1333 - 1345

Published: Feb. 1, 2025

In recent years, our understanding of sepsis has greatly advanced. However, due to the complex pathological and physiological mechanisms sepsis, are currently not fully elucidated, it is difficult translate research results into specific treatment methods. Melatonin possesses broad anti-inflammatory, antioxidant, immune-regulatory properties, making a promising therapeutic agent for sepsis. further deepened potential application prospects melatonin in The underlying protective effects multifaceted. this review, based on substantial body clinical trials animal findings, we first highlighted significance as an important biomarker disease progression prognosis We also described extensive regulatory sepsis-induced organ damage. addition its anti-oxidant effects, exerts positive by regulating metabolic disorders, hemodynamics, cell autophagy, cellular ion channels, endothelial permeability, ferroptosis other mechanisms. Furthermore, safe exogenous supplement with low toxicity, demonstrates synergistic anti-sepsis agents. face urgent medical challenge transforming increasing knowledge molecular interventions improve patient prognosis, seems be option.

Language: Английский

Citations

0
D-carvone attenuates LPS-induced acute lung injury via TLR4/NF-κB and Nrf2/HO-1 signaling pathways in rats DOI Creative Commons
Nergis Ulaş, Hilal Üstündağ, Seçkin Özkanlar

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Abstract Acute lung injury (ALI) is a severe respiratory disorder associated with high morbidity and mortality. Lipopolysaccharide (LPS) widely used to induce ALI in animal models. D-carvone, natural monoterpene, has been reported possess anti-inflammatory antioxidant properties. This study aimed investigate the protective effects of D-carvone on LPS-induced rats. Thirty-six male rats were randomly divided into six groups ( n = 6): control, (10 mg/kg 20 p.o.), LPS E. coli lipopolysaccharide i.p.), + (LPS either 10 or D-carvone). was administered orally once daily for days. On day 10, sepsis induced administration, samples collected after 6 h under deep anesthesia. administration caused significant injury, as evidenced by increased histopathological scores, upregulation pro-inflammatory markers (TLR4, IL-1β, TNF-α), oxidative stress (increased MDA, decreased GSH SOD). Treatment at both doses significantly attenuated these changes. downregulated markers, upregulated (NRF2) anti-apoptotic (Bcl-2) proteins, reduced levels cytokines (IL-1β, TNF-α, IL-8) tissues. In conclusion, protects against rats, possibly through its These findings suggest that could be potential therapeutic candidate preventing treating ALI. Graphical

Language: Английский

Citations

0
Ebselen Alleviates Sepsis‐Induced Acute Kidney Injury by Regulating Endoplasmic Reticulum Stress, Apoptosis, and Oxidative Stress DOI Creative Commons
İhsan Karaboğa, Hamza Malik Okuyan, Serdar Doğan

et al.

Veterinary Medicine and Science, Journal Year: 2025, Volume and Issue: 11(2)

Published: March 1, 2025

Acute kidney injury (AKI) is one of the most serious complications sepsis, with substantial morbidity and mortality, no effective treatment exists. Ebselen pharmacological significance in prevention a variety human diseases, such as cancer cardiovascular disorders. Nevertheless, role pathogenesis sepsis-induced AKI remains unknown. Therefore, we aimed to elucidate impact Ebselen, an active seleno-organic compound, on induced by lipopolysaccharide (LPS) associated molecular mechanisms, including endoplasmic reticulum (ER) stress, apoptosis, oxidative stress. We established rat model injecting 5 mg/kg LPS intraperitoneally. The rats were given (5 10 mg/kg, orally) before receiving injection. alleviated renal tubular reduced levels blood urea nitrogen (BUN) creatinine (CREA) LPS-induced sepsis model. Immunohistochemical terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) analyses revealed that caspase-3 expressions apoptotic cells triggered tissues. caused ER stress regulating eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) GRP78 tissue, well activating transcription 4 (ATF4) 6 (ATF6) serum. decreased malondialdehyde (MDA) LPS. modulating MDA superoxide dismutase (SOD) tissues SOD, glutathione peroxidase (GPx) serum total antioxidant status (TAS) In conclusion, report for time might alleviate through regulation apoptosis

Language: Английский

Citations

0