The Indonesian Biomedical Journal,
Journal Year:
2024,
Volume and Issue:
16(3), P. 208 - 17
Published: June 26, 2024
BACKGROUND:
Long-term
usage
of
lithium
carbonate
(Li2CO3)
as
treatment
bipolar
disorder
might
cause
nephrotoxicity.
Li2CO3-induced
nephrotoxicity
usually
treated
by
renal
dialysis,
which
is
quite
expensive.
Usage
natural
products
that
possess
anti-inflammatory
and
antioxidant
properties
biochanin
A
(BCA)
may
be
useful
against
Li2CO3
Therefore,
this
study
was
conducted
to
evaluate
nephrotoxic
effects
BCA
therapeutic
protective
it.METHODS:
Twenty-eight
rats
divided
into
4
groups:
negative
control
(NC),
Li2CO3,
+
therapeutic,
group.
Complete
blood
picture,
serum
kidney
function
tests
(urea,
creatinine,
cystatin
C)
tissue
homogenate
oxidative
stress
index
malonaldehyde
(MDA),
superoxide
dismutase
(SOD),
glutathione
S-transferase
(GST)
catalase
(CAT)
were
measured
using
enzyme
linked
immunosorbent
assay
(ELISA)
methods.
While,
histopathological
changes
evaluated
under
light
microscope.RESULTS:
administration
elicited
significant
in
hematological
parameters
hypochromic
anemia,
decreased
platelets
leukocytosis.
Serum
urea,
creatinine
C
elevated.
Renal
analysis
revealed
elevation
MDA
decline
GST,
CAT,
SOD
levels.
Kidney
histopathology
hemorrhage
between
tubules,
glomerular
capillaries
congestion,
Bowman’s
space
dilatation,
structural
alterations
tubules
cells
include
loss
brush
border,
deeply
stained
nuclei
elevated
size
number
cytoplasmic
vacuoles.
Therapeutic
groups
showed
amelioration
alteration,
functions,
markers
restoration
tissues.CONCLUSION:
has
both
possibly
through
the
reduction
stress.KEYWORDS:
A,
changes,
kidney,
salt,
stress,
effects,
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(5), P. 4721 - 4750
Published: May 14, 2024
In
the
context
of
growing
concern
regarding
appearance
and
spread
emerging
pathogens
with
high
resistance
to
chemically
synthetized
biocides,
development
new
agents
for
crops
human
protection
has
become
an
emergency.
this
context,
yeasts
present
a
huge
potential
as
eco-friendly
due
their
widespread
nature
in
various
habitats
wide
range
antagonistic
mechanisms.
The
review
focuses
on
some
major
yeast
antimicrobial
mechanisms,
molecular
basis
practical
applications
biocontrol
biomedicine.
synthesis
killer
toxins,
encoded
by
dsRNA
virus-like
particles,
dsDNA
plasmids
or
chromosomal
genes,
is
encountered
species
from
industry
can
affect
phytopathogenic
fungi
other
strains,
well
pathogenic
bacteria.
group
“red
yeasts”
gaining
more
interest
over
last
years,
not
only
natural
producers
carotenoids
rhodotorulic
acid
active
role
cell
against
oxidative
stress,
but
also
ability
inhibit
growth
yeasts,
bacteria
using
these
compounds
mechanism
competition
nutritive
substrate.
Finally,
biosurfactants
produced
characterized
stability,
specificity
biodegrability
have
proven
abilities
mycelia
formation
act
efficient
antibacterial
antibiofilm
conclusion,
activity
represents
direction
research
numerous
possibilities
bioeconomic
valorization
innovative
strategies
combat
microorganisms.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 16, 2025
Astaxanthin
is
an
antioxidant
with
extremely
high
activity.
However,
the
stability
and
solubility
of
free
astaxanthin
are
poor.
Therefore,
we
prepared
astaxanthin-betaine
(ASTA-Bet)
ionic
liquid
liposomes
through
a
combination
theoretical
calculations
experimental
research
studied
their
physicochemical
properties
biological
effects.
This
liposome
has
good
skin
permeability.
The
cumulative
permeability
ASTA-Bet
22.95
times
that
2.41
liquid.
particle
size
was
117.2
nm,
did
not
change
significantly
after
28
days
storage,
indicating
stability.
Compared
astaxanthin,
activity
can
exert
anti-inflammatory
effects
by
regulating
TGF-β1/smad2/smad3
pathway
damaged
ultraviolet
radiation,
which
may
contribute
to
resistance
radiation
damage.
it
be
used
as
raw
material
develop
cosmetics
antiaging
functions.
