The Association Between Anti‐Neoplastic Effects of Curcumin and Urogenital Cancers: A Systematic Review DOI Creative Commons
Sadegh Mazaheri‐Tehrani, Shiva Rouzbahani, Motahar Heidari‐Beni

et al.

BioMed Research International, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Background: Curcumin is a polyphenol compound with anticancer effects. We aimed to review the anti‐neoplastic effects of curcumin on urogenital cancers, by regulating different microRNA expressions. Methods: A systematic search was conducted in Medline (PubMed), Embase, Scopus, and Web Science up end August 2024. All English, vitro, observational studies that evaluated effect preventing or treating cancers through its impact expression were included. In vivo silico excluded. Result: total 2549 records found. Finally, 25 Twelve assessed prostate cancer, six ovarian three cervical bladder one study renal cancer. MicroRNAs are small noncoding RNAs regulate post‐transcriptional pathways. They possess pivotal roles fundamental mechanisms cells such as differentiation, migration, apoptosis, proliferation. exerts neoplasms upregulating tumor suppressor microRNAs (miR‐143, miR‐145, miR‐Let‐7, miR‐101, miR‐3127, miR‐3178, miR‐1275, miR‐3198, miR‐1908, miR‐770, miR‐1247, miR‐411, miR‐34a, miR‐383, miR‐708, miR‐483, miR‐199a, miR‐335, miR‐503, miR‐10b, miR‐551a, miR‐9, miR‐203, miR‐7110, miR‐29b, miR‐126) downregulating oncogenic (miR‐21, miR‐210, miR‐382, miR‐654, miR‐494, miR‐193b, miR‐671, miR‐222, miR‐23b, miR‐664, miR‐183, miR‐214, miR‐320a, miR‐23a, miR‐30a, miR‐320d, miR‐1285, miR‐32, miR‐181a, miR‐205, miR‐216a, miR‐1246, miR‐106b). Conclusion: Cell proliferation inhibited, cell apoptosis induced suppressing provoking microRNAs.

Language: Английский

Tumor Microenvironment‐Responsive Polymer‐Based RNA Delivery Systems for Cancer Treatment DOI

Yahan Zhang,

Ming Zhang,

Haiqin Song

et al.

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: May 28, 2024

Abstract Ribonucleic acid (RNA) therapeutics offer a broad prospect in cancer treatment. However, their successful application requires overcoming various physiological barriers to effectively deliver RNAs the target sites. Currently, number of RNA delivery systems based on polymeric nanoparticles are developed overcome these delivery. This work provides an overview existing for gene therapy, and particularly summarizes those that entering clinical phase. then discusses core features latest research developments tumor microenvironment‐responsive polymer‐based carriers which designed pathological characteristics microenvironment. Finally, this also proposes opportunities transformation therapies into immunotherapy methods applications.

Language: Английский

Citations

4
Global transcriptome profiling of ST09 treated breast cancer cells identifies miR-197-5p/GPX3 antioxidant axis as a regulator of tumorigenesis DOI
Snehal Nirgude, Sagar Desai, Febina Ravindran

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114127 - 114127

Published: Jan. 26, 2025

Language: Английский

Citations

0
Curcumin induces mitochondrial dysfunction-associated oxidative DNA damage in ovarian cancer cells DOI Creative Commons

Qi Bao,

Zihan Wang, Tingting Yang

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0319846 - e0319846

Published: March 31, 2025

Resistance to chemotherapeutic agents is a critical challenge for the clinical management of ovarian cancer. While curcumin has been reported possess anti-cancer properties, how it exerts its anti-neoplastic effect on cancer cells remains be explored. We here characterized fate human cell lines HO8910 and OVCAR3 treated with curcumin. Cell proliferation, death, mitochondrial function, oxidative damage tumor formation in nude mice were examined. Significant inhibition proliferation induction apoptosis observed The exhibit cycle arrest at G2/M phase, accumulation, stress high level DNA after treatment. This independent BRCA mutation status. Curcumin-induced effectively attenuated by application antioxidant N-acetylcysteine (NAC), suggesting that inflicting stress. Curcumin applied 200 mg/kg intraperitoneal infusion daily also inhibited growth, damage, accumulation xenografts vivo. Together, results indicate can exert anti-tumor via inducing dysfunction-associated potentially used combination other repair-interfering therapeutics, such as PARP inhibitor, treatment

Language: Английский

Citations

0
Identification of prognostic biomarkers for endometrioid endometrial carcinoma based on the miRNA and mRNA co‐expression network regulated by estradiol DOI Creative Commons
Qiu Xie,

Junting Huang,

Yuan Xie

et al.

Clinics, Journal Year: 2025, Volume and Issue: 80, P. 100672 - 100672

Published: Jan. 1, 2025

Endometrioid Endometrial Carcinoma (EEC), an estradiol-related disease, remains a serious health threat to women because of its high incidence and trend rejuvenation. Accumulating evidence has highlighted that microRNAs (miRNAs) messenger RNAs (mRNAs) play important roles in various biological processes involved the pathogenesis EEC. This study aimed identify potential prognostic biomarkers associated with EEC regulated by estradiol. RNA expression profiles were obtained from The Cancer Genome Atlas database (n = 408) original sequencing, which was performed on endometrial cancer Ishikawa cells treated 250 nM estradiol 3), 50 3) or control 3). TargetScan used predict target genes prognosis-related differentially expressed miRNAs (DEMs). Subsequently, functional enrichment analysis topological overlaps mRNAs (DEGs). Kaplan-Meier cell population landscapes, gene locate DEGs based single-cell transcriptomic sequencing data NCBI Sequence Read Archive database. Four prognosis, 235 overlapping screened incorporated into protein-protein interaction network visualization studies. Additionally, SACS GPR157 identified as for prognosis through survival analyses. Furthermore, transcriptome analyzed show changes levels specific types. demonstrates miR-142-5p-SACS miR-30a-5p-GPR157, are estradiol, may hold promise diagnostic novel therapeutic targets

Language: Английский

Citations

0
A review: advances of curcumin co-delivery biomaterials-based system in anti-tumor therapy DOI

Yang Fu,

Yuanxin Ge,

Shixiong Yi

et al.

Journal of Materials Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 4, 2025

Language: Английский

Citations

0
Deciphering the “Rosetta Stone” of ovarian cancer stem cells: Opportunities and challenges DOI
J Tan, Bohao Zheng, Shengtao Zhou

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189346 - 189346

Published: May 1, 2025

Language: Английский

Citations

0
Yellow-emitting carbon dots as fluorescent sensors for the rapid determination of curcumin DOI
Shen Zhang,

Jinjia Bao,

Ling Lv

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2023, Volume and Issue: 309, P. 123819 - 123819

Published: Dec. 26, 2023

Language: Английский

Citations

8
miR-181a : regulatory roles, cancer-associated signaling pathway disruptions, and therapeutic potential DOI Creative Commons
Grace McIntyre,

Zoè Jackson,

Jose A. Colina

et al.

Expert Opinion on Therapeutic Targets, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 31

Published: Dec. 8, 2024

Introduction microRNA-181a (miR-181a) is a crucial post-transcriptional regulator of many mRNA transcripts and noncoding-RNAs, influencing cell proliferation, cancer stemness, apoptosis, immune responses. Its abnormal expression well-characterized in numerous cancers, establishing it as significant genomic vulnerability biomarker research.

Language: Английский

Citations

2
Cytotoxic Activity of Curcumin- and Resveratrol-Loaded Core–Shell Systems in Resistant and Sensitive Human Ovarian Cancer Cells DOI Open Access
Joanna Weżgowiec, Zofia Łapińska, Łukasz Lamch

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 41 - 41

Published: Dec. 24, 2024

Due to the high mortality rate of ovarian cancer, there is a need find novel strategies improve current treatment modalities. Natural compounds offer great potential in this field but also require careful design systems for their delivery cancer cells. Our study explored anticancer effects resveratrol (RSV)- and curcumin (CUR)-loaded core–shell nanoparticles human We evaluated vitro cytotoxicity various nanocarriers (CUR 1-3, RSV I-III) delivered MDAH-2774 SKOV-3 cells comparison free RVS CUR after 24 h 72 treatment. A two-way ANOVA was applied compare results MTT assay. Confocal laser scanning microscopy employed visualize cellular uptake mitochondrial localization. findings revealed that with not significant, loaded effectively decreased viability The cell line more sensitive than SKOV-3. enhanced by its colocalization mitochondria were demonstrated. Further research focused on detailed biological most effective 2 3) should be conducted provide insights. These highlight promising role CUR-loaded

Language: Английский

Citations

1
Research progress on the influence of traditional Chinese medicine on tumor microenvironment therapy DOI Creative Commons
Kun Gao, Yang Cao,

Zixin Ning

et al.

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 14, 2024

More and more attention has been paid to the tumor microenvironment. The occurrence, development, metastasis, drug resistance of are closely related At same time, application traditional Chinese medicine (TCM) in prevention treatment attracted due its regulatory effect on cells holistic view multitarget TCM make it very suitable for regulation This article will review current research status molecular mechanism microenvironment from three aspects: can reverse inhibitory phenotype immune cells, enhance response clinical application.

Language: Английский

Citations

0