Bifidobacterium longum JBLC-141 alleviates hypobaric hypoxia-induced intestinal barrier damage by attenuating inflammatory responses and oxidative stress DOI Creative Commons
Xiangyang Li, Jin Shang,

Xiaojuan Wang

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 17, 2024

Hypobaric hypoxia exposure occurs at high altitudes, including plateaus, and affects normal intestinal function microbiota composition. Exposure induces an inflammatory response oxidative stress injury, ultimately disrupting homeostasis causing barrier damage. Thus, due to its anti-inflammatory, antioxidative, microbiota-regulating properties, Bifidobacterium longum is a potentially effective probiotic intervention protect the during low-pressure on plateaus. However, mechanism of action not fully defined. In this study, we investigate by which B. intervenes in damage caused plateau hypoxia. To end, vivo model established exposing rats simulated hypoxic environment. The experimental were subsequently supplemented with strain (JBLC-141) extracted from feces healthy adults Bama, Guangxi. JBLC-141 mitigates effects rat barrier. This achieved activating Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related 2 (NRF2) pathway, alleviating hypoxia-induced injury. also attenuates upregulates expression tight junction proteins claudin-1, occludin, zonula occludens-1. Furthermore, it reduces permeability, effectively ameliorating repairing histological induced addition, positively regulates microbiota, increasing relative abundance beneficial bacteria while reducing that pathogenic maintaining flora rats.

Language: Английский

Altitude illnesses DOI
Hannes Gatterer, Francisco C. Villafuerte, Silvia Ulrich

et al.

Nature Reviews Disease Primers, Journal Year: 2024, Volume and Issue: 10(1)

Published: June 20, 2024

Language: Английский

Citations

24
Potential therapeutic effects of traditional Chinese medicine in acute mountain sickness: pathogenesis, mechanisms and future directions DOI Creative Commons

Zhenhui Wu,

Yihao Wang, Rong Gao

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 4, 2024

Background and objectives Acute mountain sickness (AMS) is a pathology with different symptoms in which the organism not adapted to environment that occurs under special of high altitude. Its main mechanism organism’s tissue damage caused by acute hypobaric hypoxia. Traditional Chinese medicine (TCM) theory focuses on holistic concept. TCM has made remarkable achievements treatment many sicknesses. This review outlines pathogenesis AMS modern traditional medicine, progress animal models AMS, summarizes therapeutic effects AMS. Methods Using keywords “traditional medicine,” “herbal “acute sickness,” “high-altitude pulmonary edema,” cerebral hypoxia,” “high-altitude,” all relevant literature published up November 2023 were collected from Scopus, Web Science, PubMed, China National Knowledge Infrastructure databases, key information was analyzed. Results We systematically summarised hypoxia tissues organism, study methodology for establishment an model retrieved 18 proprietary medicines clinical The principle mainly invigorating qi, activating blood removing stasis. components botanical drugs include salidroside, ginsenoside Rg1, tetrahydrocurcumin. action through regulation HIF-1α/NF-κB signaling pathway, inhibition inflammatory response oxidative stress, enhancement energy metabolism. Conclusion unclear. Still, formulas have been used treat multifaceted interventions, such as compound danshen drip pills, Huangqi Baihe granules, Rg1. These generally exert anti-AMS pharmacological inhibiting expression VEGF, concentration MDA pro-inflammatory factors, down-regulating NF-κB/NLRP3 promoting SOD Na + -K -ATPase activities, attenuates hypoxia-induced injury. comprehensively analyses application makes suggestions more in-depth studies future, aiming provide some ideas insights subsequent studies.

Language: Английский

Citations

5
Oxy-Inflammation in Humans during Underwater Activities DOI Open Access
Alessandra Vezzoli, Simona Mrakic‐Sposta,

Andrea Brizzolari

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 3060 - 3060

Published: March 6, 2024

Underwater activities are characterized by an imbalance between reactive oxygen/nitrogen species (RONS) and antioxidant mechanisms, which can be associated with inflammatory response, depending on O2 availability. This review explores the oxidative stress mechanisms related inflammation status (Oxy-Inflammation) in underwater such as breath-hold (BH) diving, Self-Contained Breathing Apparatus (SCUBA) Closed-Circuit Rebreather (CCR) saturation diving. Divers exposed to hypoxic hyperoxic conditions, amplified environmental hyperbaric pressure, cold water, different types of breathing gases, air/non-air mixtures. The “diving response”, including physiological adaptation, cardiovascular stress, increased arterial blood peripheral vasoconstriction, altered gas values, risk bubble formation during decompression, reported.

Language: Английский

Citations

4
Inhibition effect of AGEs formation in vitro by the two novel peptides EDYGA and DLLCIC derived from Pelodiscus sinensis DOI Creative Commons
Nuo Chen, Nan Wang, Qingwei Fang

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 30, 2025

The antioxidant activity of natural products is closely related to their antiglycation effects. This study aimed examine the and elucidate underlying mechanisms two specific peptides, EDYGA (Glu-Asp-Tyr-Gly-Ala) DLLCIC (Asp-Leu-Leu-Cys-Ile-Val), derived from protein hydrolysates Pelodiscus sinensis . Both were efficient in bovine serum albumin (BSA)/glucose model inhibit BSA glycation, while showed higher than EDYGA. Firstly, it was found that could formation NEG AGEs. Moreover, able maintain secondary structure stabilize band positions (amide I & II). Additionally, molecular simulations indicated can spontaneously interact with central site BSA, specifically at Lys114 Glu424 residues, through hydrogen bonds an energy strength −0.7 kcal/mol. Furthermore, CCK-8 morphological experiments confirmed improved cell survival against AGEs-induced cytotoxicity, EC50 values 17.64 μM for 15.08 DLLCIC. These findings serve as a significant reference development effective agents prevention glycation-mediated diseases.

Language: Английский

Citations

0
Improved oxygen saturation and acclimatization with bacteriotherapy at high altitude DOI Creative Commons
James J. Yu, Esteban A. Moya, Hunter Cheng

et al.

iScience, Journal Year: 2025, Volume and Issue: 28(4), P. 112053 - 112053

Published: Feb. 17, 2025

Language: Английский

Citations

0
Metabolomic analysis of rat arterial serum under hypobaric hypoxia: Adaptive regulation of physiological systems by metabolic reprogramming DOI Creative Commons

Drosdowsky Ma,

Bing Li,

Baozhong Xin

et al.

Biochemistry and Biophysics Reports, Journal Year: 2025, Volume and Issue: 41, P. 101943 - 101943

Published: Feb. 18, 2025

Language: Английский

Citations

0
Regulatory Roles and Therapeutic Potential of miR-122-5p in Hypoxic-Ischemic Brain Injury: Comprehensive Review DOI

Abdulaziz S. Bamahel,

Xun Sun,

Wei Wu

et al.

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Language: Английский

Citations

0
Serum metabolomic profiling uncovered metabolic shifts in individuals upon moderate-altitude exposure and identified the potentiality of Beta-Alanine to ameliorate hyperuricemia DOI Creative Commons

Xuanfu Chen,

Guoxiang Zou,

Zhibo Yang

et al.

Redox Biology, Journal Year: 2025, Volume and Issue: 81, P. 103546 - 103546

Published: March 1, 2025

High-altitude exposure has been associated with an increased risk of hyperuricemia (HU) and gout, though the underlying mechanisms remain poorly understood. We conducted a comprehensive analysis serum metabolome phenome in both discovery validation cohorts Han Chinese individuals who underwent long-term moderate-altitude (∼12 months), as well independent cohort consisting local Tibetans residing Nyingchi (>5 years). Beta-Alanine intervention was applied hypoxanthine potassium oxonate-induced vitro vivo experiments. Individuals exposed to moderate altitude exhibited elevated urate increase overall medium-chain fatty acids (MCFAs), coupled decrease amino (AAs) short-chain (SCFAs). Rmcorr correlation revealed significant negative association between urate, whereas nonanoic acid versa, potentially driving lower residents. Both experiments demonstrated that inhibited xanthine oxidase (XOD) reversed HU phenotype human hepatocytes mice induced by (HX) oxonate (PO), urate-lowering effect mice. Hepatic pathology transcriptome treated indicated involved inhibition XOD, amelioration inflammation hepatocytes, promotion renal excretion. Furthermore, 10-fold cross-validation random forest classification (RFC) predictive modeling based on selected metabolites phenotypes achieved area under receiver operating characteristic (ROC) curve (AUC) value 0.93 (95 % confidence interval (CI): 0.85-1.00) 0.79 CI: 0.59-0.98) for distinguishing high asymptomatic (AHU) training dataset dataset, respectively. This study reveals altered could ameliorate hyperuricemia. Our findings suggest targeting circulating may pave novel avenues counter diseases HU.

Language: Английский

Citations

0
Simultaneous quantification of four urinary biomarkers related to oxidative stress using UHPLC-QqQ-MS/MS DOI

Yingfeng Gao,

Ruiwei Xu, Huixia Liu

et al.

Journal of Chromatography B, Journal Year: 2025, Volume and Issue: 1256, P. 124552 - 124552

Published: March 3, 2025

Language: Английский

Citations

0
Oxygen metabolism abnormalities and high-altitude cerebral edema DOI Creative Commons
Zhi Li, Jianping Zhang, Xiaoxia Zhang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 19, 2025

Hypobaric hypoxia is widely recognized as a prominent risk factor for high-altitude cerebral edema (HACE), which contributes to the exacerbation of multiple pathological mechanisms, including oxidative stress, mitochondrial dysfunction, disruption blood−;brain barrier integrity, neuroinflammation, and neuronal apoptosis. Among these abnormalities in oxygen metabolism, hypoxia, play pivotal roles pathophysiology HACE. In this review, our objective enhance comprehension underlying molecular mechanisms implicated HACE by investigating potential involvement metabolism. Addressing aberrations metabolism holds promise providing innovative therapeutic strategies managing

Language: Английский

Citations

0