npj Science of Food, Journal Year: 2024, Volume and Issue: 8(1)
Published: Dec. 19, 2024
Language: Английский
Cancers, Journal Year: 2024, Volume and Issue: 16(12), P. 2262 - 2262
Published: June 18, 2024
Melanoma, originating through malignant transformation of melanin-producing melanocytes, is a formidable malignancy, characterized by local invasiveness, recurrence, early metastasis, resistance to therapy, and high mortality rate. This review discusses etiologic risk factors for melanoma, diagnostic prognostic tools, including recent advances in molecular biology, omics, bioinformatics, provides an overview its therapy. Since the incidence melanoma rising remains unacceptably high, we discuss inherent properties, melanogenesis, that make this disease resilient treatment propose use AI solve above complex multidimensional problems. We provide on vitamin D anticancerogenic report field can solutions prevention and/or therapy melanoma. Experimental papers clinicopathological studies role status signaling pathways initiated active metabolites prognosis are reviewed. conclude signaling, defined specific nuclear receptors selective activation hydroxyderivatives, benefit new or existing therapeutic approaches. target with computational biology tools solution problem.
Language: Английский
Citations
22
European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 272, P. 116472 - 116472
Published: May 6, 2024
Language: Английский
Citations
10
Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 39, P. 101236 - 101236
Published: June 19, 2024
Language: Английский
Citations
7
Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 186, P. 118023 - 118023
Published: April 2, 2025
Language: Английский
Citations
1
Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: unknown
Published: July 28, 2024
Language: Английский
Citations
3
Cancers, Journal Year: 2024, Volume and Issue: 16(24), P. 4219 - 4219
Published: Dec. 18, 2024
Melanoma is one of the most malignant cancers, and global incidence cutaneous melanoma increasing. While melanomas are highly prone to metastasize if diagnosed late, early detection treatment significantly reduce risk mortality. Identifying patients at higher metastasis, who might benefit from adjuvant therapies, particularly important, especially with advent new treatments. Therefore, there a pressing need develop additional prognostic biomarkers for improve stratification accurately identify high-risk subgroups, ultimately enabling more effective personalized Recent advances in therapy, including targeted treatments immunotherapy, have underscored importance determining prognosis predicting response. The clinical application these markers holds potential significant advancements management. Various tumor-derived genetic, proteomic, cellular components continuously released into bloodstream cancer patients. These molecules, circulating tumor DNA RNA, proteins, cells, immune emerging as practical precise liquid cancer. In current era molecular-targeted therapies immunotherapies, an urgent integrate practice facilitate treatment. This review highlights recent discoveries biomarkers, explores challenges potentials technologies biomarker discovery, discusses future directions research.
Language: Английский
Citations
3
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 13, 2025
Extracellular matrix (ECM)-based small-diameter vascular grafts (SDVGs, inner diameter (ID) < 6 mm) hold great promise for clinical applications. However, existing ECM-based SDVGs suffer from limited donor availability, complex purification, high cost, and insufficient mechanical properties. with ECM-like structure function, good properties were rapidly prepared by optimizing common materials preparation, which can improve their prospects. Here, we an electrospinning film-collagen/red blood cell membrane-genipin hydrogel tube (ES-C/Rm-G-ht, ID = 2 the combination of cross-linking genipin, plastic compression, electrospinning, rolling without a biological adhesive, had shorter preparation time less than 17 h compared to (preparation 4-18 weeks). ES-C/Rm-G-ht exhibited layered honeycomb-like demonstrated functions promote proliferation migration endothelial cells, prevent thrombus inflammation. Furthermore, ES-C/Rm-G-ht, possessing sufficient strength, showed patency, rapid endothelialization (95%), regeneration smooth muscle layers ECM, effective antistenosis capability after implantation in rabbit's carotid artery 31 days. This work provides straightforward, cost-effective, promising strategy prepare is ideal alternative autologous vessels current clinic.
Language: Английский
Citations
0
Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 225 - 225
Published: Jan. 17, 2025
Malignant melanoma (MM) is a malignant tumor, resulting from mutations in melanocytes of the skin and mucous membranes. Its mortality rate accounts for 90% all dermatologic tumor mortality. Traditional treatments such as surgery, chemotherapy, radiotherapy are unable to achieve expected results due MM's low sensitivity, high drug resistance, toxic side effects. As treatment advances, immunotherapy targeted therapy have made significant breakthroughs MM demonstrated promising application prospects. However, heterogeneity immune response causes more than half patients not benefit clinical therapy, which delays patient's condition them suffer adverse events' The combination can help improve therapeutic effects, delay mitigate This review provides comprehensive overview current development status research progress checkpoints, genes, their inhibitors, with view providing reference MM.
Language: Английский
Citations
0
FEBS Open Bio, Journal Year: 2025, Volume and Issue: unknown
Published: May 12, 2025
Dysregulation of cytokine signaling is central to the development and progression cancer. Cytokines are not only involved in promoting cancer but also regulate anti‐tumor immune responses. Circular RNAs (circRNAs) single‐stranded, covalently closed RNA molecules lacking free ends, which have emerged as critical regulators signaling. Transcriptional post‐transcriptional regulation by circRNAs contributes pathogenesis. Here, we discuss emerging role modulating pathways that development. In particular, examine TGF‐β, IL‐6, IL‐10, TNF‐α, VEGF, FGF, PDGF, chemokine
Language: Английский
Citations
0
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: May 21, 2025
Abstract The niche microenvironment plays a crucial role in regulating the fate of normal skin stem cells (SSCs) and cancer (CSCs). Therapeutically targeting CSC holds promise as an effective strategy; however, dual effects shared SSC signaling CSCs have contributed to aggressive characteristics tumors poor survival rates patients. lack clear underlying mechanism has significantly hindered drug development for treatment. This article explores recent advances understanding how factors regulate cell determination between CSCs, along with their clinical implications. roles key components adhesive niche, including dermo-epidermal junction adherens junction, various types—especially immune fibroblasts—as well major pathways such Sonic hedgehog (Shh), Wingless-related integration site (Wnt)/β-catenin, YAP (Yes-associated protein)/TAZ (transcriptional coactivator PDZ-binding motif), Notch, are highlighted. Additionally, trials these discussed. Overall, this review provides valuable insights into complex interactions microenvironment, laying groundwork future research strategies.
Language: Английский
Citations
0