Pathogenesis of Inflammation in Skin Disease: From Molecular Mechanisms to Pathology

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10152 - 10152

Published: Sept. 21, 2024

Many skin diseases begin with inflammatory changes on a molecular level. To develop more thorough understanding of pathology and to identify new targets for therapeutic advancements, mechanisms inflammation in the context disease should be studied. Current research efforts better understand have focused examining role processes at several stages response such as dysregulation innate immunity sensors, disruption both transcriptional post-transcriptional regulation, crosstalk between immune neuronal (neuro-immune crosstalk). This review seeks summarize recent developments our highlight opportunities advancements. With focus publications within past 5 years (2019–2024), databases PubMed EBSCOhost were used search peer-reviewed papers regarding disease. Several themes interest determined through extensive included based their relative representation current potential. psoriasis, atopic dermatitis, hidradenitis suppurativa, scleroderma described paper demonstrate widespread influence

Language: Английский

Role of DNA Methylation in the Pathogenesis of Skin Disorders: Mechanisms, Inhibitors of Methylation‐Related Enzyme, and Molecular Docking Studies

BioMed Research International, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

DNA methylation is an epigenetic mechanism modulating gene expression without altering the genetic sequence and plays a significant role in skin disorders. Methylation patterns on specific genes can lead to either overexpression or suppression, impacting cellular functions critical health. Skin disorders such as atopic dermatitis, eczema, androgenetic alopecia, systemic lupus erythematosus, psoriasis, sclerosis have been linked abnormal methylation, which contributes disease progression through immune dysregulation, barrier dysfunction, inflammation. The of like S100A2 FCERIG dermatitis FLG eczema illustrates how modifications affect pathways integrity. Recent advancements analysis enhanced precision detecting levels their influence expression, leading deeper understanding mechanisms. Identifying aberrant offers potential biomarkers for early diagnosis therapeutic targets, especially autoimmune inflammatory diseases. Further exploration changes could pave way innovative treatments, addressing underlying disruptions that characterize these conditions.

Language: Английский

The Relationship Between Chronic Pruritus, Attention-Deficit/Hyperactivity Disorder, and Skin Picking—A Case Series and Narrative Review

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1774 - 1774

Published: March 6, 2025

Chronic pruritus (CP), attention-deficit/hyperactivity disorder (ADHD), and skin picking (SPD) are medical conditions that involve both somatic psychosocial dimensions, posing unique challenges in clinical management. While CP SPD often observed together, the link between ADHD these is less recognized. This conceptual work describes three women who suffered from a complex interplay of CP, ADHD, treated at our specialized bi-disciplinary psychodermatological clinic. Based on observation narrative review literature, we assume bidirectional, triangular relationship SPD. To support this assumption, propose two hypotheses: (1) neurodevelopmental hypothesis, emphasizing an underlying disorder, case, might present with symptoms like dysfunction sensory processing, impulsivity, attention deficits as shared features reinforce SPD, (2) neuroinflammatory suggesting similar signatures promote co-occurrence In addition, provide specific suggestions derived experience how to manage patients combination conditions. Elucidating help develop personalized treatment strategies improve outcomes.

Language: Английский