MicroRNA Expression in Chronic Venous Leg Ulcers and Implications for Wound Healing: A Scoping Review DOI
Magali Rezende de Carvalho, Hyehwan Yang,

Joyce K. Stechmiller

et al.

Biological Research For Nursing, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Purpose: Chronic venous leg ulcers (CVLUs) comprise the majority of lower-extremity wounds, yet their pathophysiology is not fully understood. While research has shown that microRNAs are an important component wound inflammation, few have explored role (miRNAs) in healing CVLUs. This scoping review examines miRNAs CVLUs and association with healing. Methods: In December 2023, we searched MEDLINE/PubMed, Embase, Scopus, CINAHL for studies published 2013–2023 examining CVLU Results: Six met inclusion criteria. MicroRNAs were extracted from various specimens including serum, skin biopsy samples, adipose tissue-derived mesenchymal cells individuals Overexpression miR-221, miR-222, miR-92a, miR-301a-3p hindered angiogenesis, while overexpression miR-296, miR-126, miR-378, miR-210 facilitated angiogenesis. miR-34a/c, miR-301a-3p, miR-450-5p, miR-424-5p, miR-516-5p, miR-7704 increased local inflammatory responses inhibited keratinocytes proliferation, impairing healing, miR-19a/b miR-20 downregulated keratinocytes' response, promoting Downregulation miR-205, miR-96-5p, miR-218-5p enhanced cellular proliferation promoted miR-17–92 was linked impaired Discussion: play a regulating responses, cell migration chronic-wound However, limited lack standardized approach to measurement quantification. Further warranted elucidate mechanisms underlying microRNA involvement better understand future development targeted therapies.

Language: Английский

Enhancing the performance of injectable self-activating PVA-alginate hydrogel by Ag@MXene nanozyme as NIR responsive and photoenhanced antibacterial platform for wound healing DOI

Zepeng Liang,

Zelin Sang,

Yumei Li

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 357, P. 123434 - 123434

Published: Feb. 27, 2025

Language: Английский

Citations

3
Nitric oxide-based treatments improve wound healing associated with diabetes mellitus DOI
Zahra Bahadoran, Parvin Mirmiran,

Farhad Hosseinpanah

et al.

Medical Gas Research, Journal Year: 2024, Volume and Issue: 15(1), P. 23 - 35

Published: July 25, 2024

Non-healing wounds are long-term complications of diabetes mellitus (DM) that increase mortality risk and amputation-related disability decrease the quality life. Nitric oxide (NO·)-based treatments (i.e., use both systemic topical NO· donors, precursors, inducers) have received more attention as complementary approaches in DM wounds. Here, we aimed to highlight potential benefits NO·-based on through a literature review experimental clinical evidence. Various been used. In rodents, therapy facilitates wound healing, manifested an increased healing rate decreased half-closure time. The effect is attributed increasing local blood flow, angiogenesis induction, collagen synthesis deposition, re-epithelization, anti-inflammatory anti-oxidative properties, potent broad-spectrum antibacterial effects. existing lacks human evidence safety efficacy for Translating favors into practice needs conducting trials with well-predefined sizes, i.e., reduction area, hospital length stay.

Language: Английский

Citations

4
Supramolecular approach to the design of nanocarriers for antidiabetic drugs: targeted patient-friendly therapy DOI
Л. А. Васильева, Gulnara A. Gaynanova,

E. A. Romanova

et al.

Russian Chemical Reviews, Journal Year: 2024, Volume and Issue: 93(11), P. RCR5150 - RCR5150

Published: Oct. 30, 2024

Diabetes and its complications derived are among serious global health concerns that critically deteriorate the quality of life patients and, in some cases, result lethal outcome. Herein, general information on pathogenesis, factors aggravating course disease drugs used for treatment two types diabetes briefly discussed. The aim review is to introduce supramolecular strategies currently being developed mellitus present a very effective alternative chemical synthesis, allowing fabrication nanocontainers with switchable characteristics meet criteria green chemistry. Particular attention paid organic (amphiphilic polymeric) formulations, including those natural origin, due their biocompatibility, low toxicity, bioavailability. advantages limitations different nanosystems discussed, emphasis adaptivity noninvasive administration routes.<br>The bibliography includes 378 references.

Language: Английский

Citations

4
Recent trends in hydrogel-based formulation for the treatment of diabetic wounds: A Review DOI
Bedanta Bhattacharjee,

K Sandhanam,

Damanbhalang Rynjah

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106848 - 106848

Published: March 1, 2025

Language: Английский

Citations

0
Phyto-mediated polymeric incorporated silver nano-bio-composite for improved dermal complication management: A review DOI Creative Commons
Min He, Jun Hu, J. S. Deng

et al.

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102272 - 102272

Published: April 1, 2025

Language: Английский

Citations

0
Wound Healing in the Modern Era: Emerging Research, Biomedical Advances, and Transformative Clinical Approaches DOI

Subhasri Bogadi,

Md Uddin,

M. Habibur Rahman

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 107058 - 107058

Published: May 1, 2025

Language: Английский

Citations

0
Precision exosome engineering for enhanced wound healing and scar revision DOI Creative Commons
Chuanqi Liu, Cheng Chen, Kun Cheng

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 23, 2025

The dysfunction of wound-healing processes can result in chronic non-healing wounds and pathological scar formation. Current treatment options often fall short, necessitating innovative approaches. Exosomes, extracellular vesicles secreted by various cells, have emerged as promising therapeutic agents serving an intercellular communication system. By engineering exosomes, their cargo surface properties be tailored to enhance efficacy specificity. Engineered exosomes (eExo) are emerging a favorable tool for treating scars. In this review, we delve into the underlying mechanisms scars, outline current state strategies, explore clinical potential eExo based on preclinical studies. addition, address challenges future research directions, including standardization, safety assessments, immune responses. conclusion, hold great promise novel approach Further trials warranted translate findings effective treatments.

Language: Английский

Citations

0
MicroRNA Expression in Chronic Venous Leg Ulcers and Implications for Wound Healing: A Scoping Review DOI
Magali Rezende de Carvalho, Hyehwan Yang,

Joyce K. Stechmiller

et al.

Biological Research For Nursing, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Purpose: Chronic venous leg ulcers (CVLUs) comprise the majority of lower-extremity wounds, yet their pathophysiology is not fully understood. While research has shown that microRNAs are an important component wound inflammation, few have explored role (miRNAs) in healing CVLUs. This scoping review examines miRNAs CVLUs and association with healing. Methods: In December 2023, we searched MEDLINE/PubMed, Embase, Scopus, CINAHL for studies published 2013–2023 examining CVLU Results: Six met inclusion criteria. MicroRNAs were extracted from various specimens including serum, skin biopsy samples, adipose tissue-derived mesenchymal cells individuals Overexpression miR-221, miR-222, miR-92a, miR-301a-3p hindered angiogenesis, while overexpression miR-296, miR-126, miR-378, miR-210 facilitated angiogenesis. miR-34a/c, miR-301a-3p, miR-450-5p, miR-424-5p, miR-516-5p, miR-7704 increased local inflammatory responses inhibited keratinocytes proliferation, impairing healing, miR-19a/b miR-20 downregulated keratinocytes' response, promoting Downregulation miR-205, miR-96-5p, miR-218-5p enhanced cellular proliferation promoted miR-17–92 was linked impaired Discussion: play a regulating responses, cell migration chronic-wound However, limited lack standardized approach to measurement quantification. Further warranted elucidate mechanisms underlying microRNA involvement better understand future development targeted therapies.

Language: Английский

Citations

0