Vutiglabridin exerts anti-ageing effects in aged mice through alleviating age-related metabolic dysfunctions DOI Creative Commons

Jooseung Hyeon,

Jihan Lee, Eunju Kim

et al.

Experimental Gerontology, Journal Year: 2023, Volume and Issue: 181, P. 112269 - 112269

Published: Sept. 1, 2023

Ageing alters the ECM, leading to mitochondrial dysfunction and oxidative stress, which triggers an inflammatory response that exacerbates with age. Age-related changes impact satellite cells, affecting muscle regeneration, balance of proteins. Furthermore, ageing causes a decline in NAD+ levels, alterations fat metabolism our health. These various metabolic issues become intricately intertwined ageing, variety individual-level diseases profoundly individuals' healthspan. Therefore, we hypothesize vutiglabridin capable alleviating these abnormalities will be able ameliorate many problems associated ageing.The efficacy vutiglabridin, alleviates by enhancing function, was assessed aged mice treated compared untreated elderly mice. On young mice, vutiglabridin-treated non-treated Senescence-associated beta-galactosidase staining q-PCR for marker genes were carried out. Bulk RNA-seq out on GA muscle, eWAT, liver from each group compare differences gene expression pathways. Blood used analyze lipid profile.SA-β-gal liver, kidney, spleen showed had anti-ageing effects control group, including Cdkn1a Cdkn2a tissue reduced process. In improved homeostasis controls, eWAT restored insulin sensitivity prevented FALC-induced inflammation, inflammation levels due TLO formation, complex I assembly, resulting ROS formation. blood analysis revealed ageing-related profile relieved versus group.Vutiglabridin slows mechanisms such as decreased sensitivity, increased altered adipose experiments, while also retaining homeostasis, is deteriorated It improves restores function reduce generation.

Language: Английский

Effects of dietary sodium acetate on intestinal health of juvenile Trachinotus ovatus based on multi-omics approach DOI
Pengwei Xun, Chuanpeng Zhou, Xiaolin Huang

et al.

Aquaculture, Journal Year: 2022, Volume and Issue: 562, P. 738776 - 738776

Published: Sept. 1, 2022

Language: Английский

Citations

15
Spatial distribution of the Shannon entropy for mass spectrometry imaging DOI Creative Commons
Lili Xu, Kenji Kikushima,

Shumpei Sato

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(4), P. e0283966 - e0283966

Published: April 6, 2023

Mass spectrometry imaging (MSI) allows us to visualize the spatial distribution of molecular components in a sample. A large amount mass data comprehensively provides distributions. In this study, we focus on information obtained and use Shannon entropy as quantity analyze MSI data. By calculating at each pixel sample, is from We found that low-entropy pixels heat maps for kidneys mice had different structures between two ages (3 months 31 months). Such changes cannot be visualized by conventional techniques. further propose method find informative molecules. As demonstration proposed scheme, identified molecules setting region interest which contained exploring peaks region.

Language: Английский

Citations

7
Phosphatidylethanolamine N-Methyltransferase Knockout Modulates Metabolic Changes in Aging Mice DOI Creative Commons
Qishun Zhou, Fangrong Zhang,

Jakob Kerbl-Knapp

et al.

Biomolecules, Journal Year: 2022, Volume and Issue: 12(9), P. 1270 - 1270

Published: Sept. 9, 2022

Phospholipid metabolism, including phosphatidylcholine (PC) biosynthesis, is crucial for various biological functions and associated with longevity. Phosphatidylethanolamine N-methyltransferase (PEMT) a protein that catalyzes the biosynthesis of PC, levels which change in organs such as brain kidneys during aging. However, role PEMT systemic PC supply not fully understood. To address how affects aging-associated energy metabolism tissues responsible nutrient absorption, lipid storage, consumption, we employed NMR-based metabolomics to study liver, plasma, intestine (duodenum, jejunum, ileum), brown/white adipose (BAT WAT), skeletal muscle young (9–10 weeks) old (91–132 wild-type (WT) knockout (KO) mice. We found effect PEMT-knockout was tissue-specific age-dependent. A deficiency affected metabolome all examined, among BAT from both aged KO mice dramatically changed comparison WT mice, whereas jejunum only slightly affected. As aging, absence increased divergence aging WAT, duodenum, ileum decreased impact on muscle. Overall, our results suggest plays previously underexplored, critical metabolism.

Language: Английский

Citations

10
Phospholipids, the Masters in the Shadows during Healing after Acute Myocardial Infarction DOI Open Access
Dan-Valentin Pistritu,

Anisia-Cristiana Vasiliniuc,

Anda Vasiliu

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8360 - 8360

Published: May 6, 2023

Phospholipids are major components of cell membranes with complex structures, high heterogeneity and critical biological functions have been used since ancient times to treat cardiovascular disease. Their importance role were shadowed by the difficulty or incomplete available research methodology study their presence functionality. This review focuses on current knowledge about roles phospholipids in pathophysiology therapy diseases, which increasingly recognized. Used singular formulation inclusive combinations drugs, proved positive valuable effects not only protection myocardial tissue, inflammation fibrosis but also angiogenesis, coagulation cardiac regeneration more frequently animal models as well human pathology. Thus, while mainly neglected scientific community, present negligible side could represent an ideal target for future therapeutic strategies healing infarction. Acknowledging understanding mechanisms action offer a new perspective into novel patients suffering acute infarction, reducing burden improving general social economic outcome.

Language: Английский

Citations

6
Insights into the Anti-Aging Prevention and Diagnostic Medicine and Healthcare DOI Creative Commons

Seung-Cheol Ok

Diagnostics, Journal Year: 2022, Volume and Issue: 12(4), P. 819 - 819

Published: March 26, 2022

Aging is an irreversible and natural phenomenon that occurs as a person ages. Anti-aging medicine applies advanced science medical technology to early detection, prevention, treatment, reversal of age-related dysfunctions, disorders, diseases. Therefore, anti-aging diagnostic healthcare are important factors in helping the elderly population lead healthy active lives. However, it challenging diagnose various aging related diseases accurately through forms health management. It may not be treated appropriately, so many older people making efforts prevent themselves advance. care have been developed forms, from checkups alternative biophysical beyond simple clinical medicine, being applied demand needs elderly. This review intends explore characterize applications In addition, economic, medical, ethical considerations arising relationship between increase continuous development can considered.

Language: Английский

Citations

10
Saponins from bitter melon reduce lipid accumulation via induction of autophagy in C. elegans and HepG2 cell line DOI Creative Commons
Juan Bai, Ying Zhu,

Linzhao He

et al.

Current Research in Food Science, Journal Year: 2022, Volume and Issue: 5, P. 1167 - 1175

Published: Jan. 1, 2022

Saponins from bitter melon (BMS) are well-known to have various biological activities, especially in the field of fat-lowering. However, many gaps remain our knowledge BMS-induced fat reduction and health benefits. Here, we aimed investigate precise mechanism BMS alleviating accumulation C. elegans HepG2 cell line. Results indicated that showed strong fat-lowering lifespan-extension properties. Lipidomic analysis illustrated could alter lipid profile, represented by phosphatidylethanolamine (PE) increase, which plays an essential role autophagy. Furthermore, applied gene-deficient mutants RNAi technology confirm largely depended on daf-16/FoxO1 hlh-30/TFEB mediated lipophagy reduce deposition. In addition, ameliorate oil acid (OA)-induced cells induction autophagy-related proteins, such as phosphorylated AMPK LC3B. conclusion, results elucidated underlying saponins interfering with metabolism autophagy point view, provide new insights into a nutraceutical mitigate obesity.

Language: Английский

Citations

9
Hormesis in Caenorhabditis elegans exposed to pollutants DOI
Zhenyang Yu, Jing Zhang, Linhong Jiang

et al.

Current Opinion in Environmental Science & Health, Journal Year: 2022, Volume and Issue: 29, P. 100377 - 100377

Published: June 22, 2022

Language: Английский

Citations

8
α‐Glyceryl‐phosphoryl‐ethanolamine protects human hippocampal neurons from ageing‐induced cellular alterations DOI Creative Commons
Elisa Zappelli, Simona Daniele, Lorenzo Ceccarelli

et al.

European Journal of Neuroscience, Journal Year: 2022, Volume and Issue: 56(5), P. 4514 - 4528

Published: July 29, 2022

Brain ageing has been related to a decrease in cellular metabolism, an accumulation of misfolded proteins and alteration the lipid membrane composition. These alterations act as contributive aspects age-related memory decline by reducing excitability neurotransmitter release. In this sense, precursors phospholipids (PLs) can restore physiological composition membranes ameliorate defects associated with brain ageing. particular, phosphatidylcholine (PC) phosphatidylethanolamine (PE) have shown mitochondrial function, reduce amyloid beta (Aβ) and, at same time, provide amount acetylcholine needed deficit. Among PL precursors, alpha-glycerylphosphorylethanolamine (GPE) protect astrocytes from Aβ injuries slow-down human neural stem cells. GPE evaluated aged hippocampal neurons, which are implicated learning memory, constitute good vitro model investigate beneficial properties GPE. order mimic ageing, cells maintained 21 days challenged Results present paper showed ability increase PE PC content, glucose uptake activity chain respiratory complex I GSK-3β pathway. Moreover, nootropic compound transcriptional/protein levels neurotrophic well-being genes. Finally, counteracted ageing-related (a-synuclein tau). Overall, our data underline promising effects counteracting cognitive decline.

Language: Английский

Citations

7
Poplar Bud (Populus) Extraction and Chinese Propolis Counteract Oxidative Stress in Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway DOI Creative Commons
Shuo Wang, Chengchao Yang,

Yaling Luo

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 860 - 860

Published: July 18, 2024

Poplar buds are characterized by a high content of phenolic compounds, which exhibit broad spectrum biological activities. However, the relationship between Chinese propolis and poplar based on their antioxidant capacities underlying mechanisms remains unclear. This study aimed to investigate properties bud (

Language: Английский

Citations

1
Antioxidants in Aging DOI Creative Commons
Harpreet Singh, Sourav Mohanto, Adrija Bhunia

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: unknown, P. 257 - 283

Published: Nov. 17, 2024

The chapter provides a comprehensive overview of the relationship between oxidative stress and aging process. Oxidative arises from an imbalance production Reactive Oxygen Species (ROS) body's antioxidant defense system. mechanisms action antioxidants are explored, including enzymatic non-enzymatic antioxidants, metal-binding proteins, dietary sources, nutritional supplements. also delves into role in cellular senescence Furthermore, effectiveness supplements combating is examined. highlights impact on skin health aging, discusses use topical anti-aging cosmetics. Lifestyle factors such as exercise, stress, sleep, smoking, alcohol consumption explored contributors to diminished defense. concludes with discussion potential for personalized interventions development novel compounds plants, marine, microorganisms, synthetic sources future research. Overall, this valuable insights promoting healthy aging.

Language: Английский

Citations

1