Cited by Remodeling of tumor microenvironment by cellular senescence and immunosenescence in cervical cancer

Gut microbiota and immunosenescence in cancer DOI

Yaozheng Xu,

Chuan He,

Ying Xi

et al.

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 104-105, P. 32 - 45

Published: Aug. 8, 2024

Language: Английский

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Metabolomic Hallmarks of Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease DOI

Diren Beyoğlu, Yury Popov, Jeffrey R. Idle

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12809 - 12809

Published: Nov. 28, 2024

From a detailed review of 90 experimental and clinical metabolomic investigations obesity metabolic dysfunction-associated steatotic liver disease (MASLD), we have developed hallmarks for both MASLD. Obesity studies were conducted in mice, rats, humans, with consensus biomarker groups plasma/serum being essential nonessential amino acids, energy metabolites, gut microbiota acylcarnitines lysophosphatidylcholines (LPC), which formed the basis six obesity. Additionally, mice rats shared elevated cholesterol, humans fatty VLDL/LDL, bile acids phosphatidylcholines (PC). MASLD had been performed hamsters, cows, geese, blunt snout breams, zebrafish, agreement between lay foundation five Furthermore, group higher LPC/PC cholesteryl esters, acylcarnitines, lysophosphatidylethanolamines/phosphatidylethanolamines (LPE/PE), triglycerides/diglycerides, metabolites. These aid understanding role played by development, inform mechanistic into underlying pathogenesis, are critical new metabolite-inspired therapies.

Language: Английский

Citations

The impact of serum uric acid on biological aging and mortality risk: insights from the NHANES and CHARLS cohorts DOI

Cong Zhao, Ling Zhao, Yang Liu

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 22, 2025

Serum uric acid (SUA), a byproduct of purine metabolism, exerts both antioxidant and pro-inflammatory effects, making its role in aging chronic diseases subject ongoing debate. Despite this, the mechanisms by which SUA influences process remain poorly understood. We analyzed data from NHANES (1999-2010) CHARLS (2011-2015) cohorts to investigate SUA's impact on biological aging. Generalized linear regression models assessed effect markers [ΔKDM-BA, ΔPhenoAge, allostatic load (AL)], while Cox estimated association with all-cause premature mortality. Dose-response relationships between levels (ΔKDM-BA, AL), as well mortality, were evaluated using restricted cubic splines (RCS). In cohorts, elevated significantly associated accelerated cohort, for each 1 mg/dL increase SUA, ΔKDM-BA increased 0.52 years (95% CI: 0.43-0.61, p < 0.0001), AL 0.38 0.29-0.47, 0.0001). was similarly linked an 0.65 0.57-0.74, 0.0001) 0.15 0.12-0.18, RCS analysis revealed nonlinear NHANES, more pronounced acceleration when exceeded 4.16 (nonlinear CHARLS, showed relationship = 0.01). Additionally, (HR: 1.04, 95% 1.01-1.07, 0.01) mortality 1.06, 1.00-1.13, 0.046). further demonstrated U-shaped contrast, did not show significant outcomes cohort. Elevated is U.S. Chinese populations, but link evident only These findings highlight potential marker call population-specific investigation.

Language: Английский

Citations

Remodeling of tumor microenvironment by cellular senescence and immunosenescence in cervical cancer DOI

Yijiang He,

Yue Qiu,

Xiansong Yang

et al.

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 108, P. 17 - 32

Published: Nov. 23, 2024

Language: Английский

Citations