A new player in the game: identification of C1ql1 as a novel factor driving OPC differentiation DOI
Jana Van Broeckhoven, Femke Mussen, Melissa Schepers

et al.

FEBS Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Oligodendrocytes (OLGs) are the myelin‐producing cells in central nervous system (CNS). Following injury, these prone to death, leading demyelination and, eventually, axonal loss and neurodegeneration. Upon damaged CNS repopulates lesion with oligodendrocyte precursor (OPCs) that consequently mature into OLGs repair myelin damage prevent further loss. In this issue, Altunay et al. identified complement component 1, q subcomponent‐like‐1 ( C1ql1 ), a factor known play role neuron–neuron synapses, is also expressed by OPCs drives their differentiation OLGs. These data suggest or other downstream factors could be therapeutic targets context of demyelinating disorders which remyelination fails, such as multiple sclerosis (MS).

Language: Английский

The Rise of Pluripotent Stem Cell-Derived Glia Models of Neuroinflammation DOI Creative Commons
Srishti Kala, Andrew G. Strutz, Moriah E. Katt

et al.

Neurology International, Journal Year: 2025, Volume and Issue: 17(1), P. 6 - 6

Published: Jan. 13, 2025

Neuroinflammation is a blanket term that describes the body’s complex inflammatory response in central nervous system (CNS). It encompasses phenotype shift to proinflammatory state, release of cytokines, recruitment peripheral immune cells, and wide variety other processes. has been implicated nearly every major CNS disease ranging from Alzheimer’s brain cancer. Understanding modeling neuroinflammation critical for identification novel therapeutic targets treatment diseases. Unfortunately, translation findings non-human models left much be desired. This review systematically discusses role human pluripotent stem cell (hPSC)-derived glia supporting cells within CNS, including astrocytes, microglia, oligodendrocyte precursor pericytes, endothelial describe state field hope future discoveries. hPSC-derived offer an expanded potential study pathobiology immunomodulatory cascades impact progression. While progress made development models, there explore application these understand CNS.

Language: Английский

Citations

0
A dual role for pleiotrophin in modulating inflammation and myelination in the presence of chondroitin sulfate proteoglycans after nervous system injury DOI Creative Commons
Somnath J. Gupta, Matthew A. Churchward, Kathryn G. Todd

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 27, 2025

Chondroitin sulfate proteoglycans (CSPGs), key components of the extracellular matrix and glial scar that forms around central nervous system (CNS) injuries, are recognized for hindering neuronal regeneration. We previously demonstrated potential pleiotrophin (PTN) to induce neurite outgrowth even in presence inhibitory CSPGs. The effects PTN on microglia oligodendrocytes not well described. Here, we examined how administration alters differentiation oligodendrocyte precursor cells (OPCs) into mature CSPGs using vitro cell culture model. Moreover, explored inflammatory activity with without stimulation (IFN-γ) a CSPG-rich environment. data showed CSPG inhibited OPCs oligodendrocytes. induced dose-dependent oligodendrocytes, an optimal effect at 10 nM PTN. modified immunological response CSPGs, reduced proinflammatory was further by administration, contrast increased release metalloproteinases (MMP 9). However, when IFN-γ-activated were treated PTN, signaling stimulated higher concentrations (10 100 nM). Overall, our results indicate can overcome modulate inflammation mediated from microglia. Collectively, these findings demonstrate effectively counteract while also modulating microglial responses reduce increase MMP-9 release. Thus, has great improve remyelination neuroprotective strategies treatment demyelinating diseases or any injury.

Language: Английский

Citations

0
Insights from Selenoprotein I mouse models for understanding biological roles of this enzyme DOI
Lance G. A. Nunes, Chi Ma, Matthew W. Pitts

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown, P. 110394 - 110394

Published: March 1, 2025

Language: Английский

Citations

0
Alzheimer’s Disease, Obesity, and Type 2 Diabetes: Focus on Common Neuroglial Dysfunctions (Critical Review and New Data on Human Brain and Models) DOI Creative Commons
A. Tolédano, Arantxa Rodrı́guez-Casado,

María‐Isabel Álvarez

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 1101 - 1101

Published: Oct. 30, 2024

Obesity, type 2 diabetes (T2D), and Alzheimer's disease (AD) are pathologies that affect millions of people worldwide. They have no effective therapy difficult to prevent control when they develop. It has been known for many years these diseases pathogenic aspects in common. We highlight this review neuroglial cells (astroglia, oligodendroglia, microglia) play a vital role the origin, clinical-pathological development, course brain neurodegeneration. Moreover, we include new results T2D-AD mouse model (APP+PS1 mice on high-calorie diet) investigating.

Language: Английский

Citations

3
(Re)building the nervous system: A review of neuron–glia interactions from development to disease DOI Creative Commons
Matthew D. Demmings, Luana da Silva Chagas, Marianela E. Traetta

et al.

Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: 169(1)

Published: Dec. 16, 2024

Abstract Neuron–glia interactions are fundamental to the development and function of nervous system. During development, glia, including astrocytes, microglia, oligodendrocytes, influence neuronal differentiation migration, synapse formation refinement, myelination. In mature brain, glia crucial for maintaining neural homeostasis, modulating synaptic activity, supporting metabolic functions. Neurons, inherently vulnerable various stressors, rely on protection repair. However, in their reactive state, can also promote damage, which contributes neurodegenerative neuropsychiatric diseases. Understanding dual role glia—as both protectors potential aggressors—sheds light complex contributions disease etiology pathology. By appropriately glial it may be possible mitigate neurodegeneration restore function. this review, originated from International Society Neurochemistry (ISN) Advanced School 2019 held Montreal, Canada, we first describe critical importance maintenance a healthy system as well damage neurological disorders. We then discuss strategies modulate activity during protect properly functioning propose that targeting cells presents promising therapeutic avenue rebuilding image

Language: Английский

Citations

2
A new player in the game: identification of C1ql1 as a novel factor driving OPC differentiation DOI
Jana Van Broeckhoven, Femke Mussen, Melissa Schepers

et al.

FEBS Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Oligodendrocytes (OLGs) are the myelin‐producing cells in central nervous system (CNS). Following injury, these prone to death, leading demyelination and, eventually, axonal loss and neurodegeneration. Upon damaged CNS repopulates lesion with oligodendrocyte precursor (OPCs) that consequently mature into OLGs repair myelin damage prevent further loss. In this issue, Altunay et al. identified complement component 1, q subcomponent‐like‐1 ( C1ql1 ), a factor known play role neuron–neuron synapses, is also expressed by OPCs drives their differentiation OLGs. These data suggest or other downstream factors could be therapeutic targets context of demyelinating disorders which remyelination fails, such as multiple sclerosis (MS).

Language: Английский

Citations

0