The Key Role of Brain-Derived Neurotrophic Factor (BDNF) in Pathophysiology of Glaucoma and Its Therapeutic Potential DOI

Muhammad Usman Durrani,

Aliyu Jalam USMAN,

Fakhra Noureen

et al.

Pakistan Journal of Health Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 240 - 247

Published: Oct. 31, 2024

Glaucoma, a leading cause of irreversible blindness, is increasingly recognized as neurodegenerative disease affecting broader neuro-ophthalmic pathways. Brain-derived neurotrophic Factor crucial neurotrophin, that supports the growth, maintenance, and survival neurons has been implicated in glaucomatous damage where its levels are diminished. Objectives: To focus on role Brain-Derived Neurotrophic pathophysiology glaucoma therapeutic potential by enhancing retinal ganglion cells. Methods: The studies this review taken from well-known public libraries for scientific research such PubMed (60%), Science Direct (25%) Springer Link (15%), line with PRISMA guidelines. Various works conducted over past decade different parts world, including North America, Europe, Asia, have provided evidence augmentation signalling may be very effective approach to managing or halting progression optic neuropathy through neuroprotection improving cells survival. Results: Studies both animals humans indicate downstream signals promote decrease extent apoptotic cell death, oxidative stress, inflammation glaucoma. Moreover, enhancements neuroprotective effects supported factors Nerve growth factor Factor. Conclusion: It was concluded used diagnostic marker Glaucoma well it could evaluated against disease.

Language: Английский

Ocular Inflammation and Oxidative Stress as a Result of Chronic Intermittent Hypoxia: A Rat Model of Sleep Apnea DOI Creative Commons

N. T. Donkor,

Jennifer J. Gardner, Jessica L. Bradshaw

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 878 - 878

Published: July 22, 2024

Obstructive sleep apnea (OSA) is a disorder characterized by intermittent complete or partial occlusion of the airway. Despite recognized association between OSA and glaucoma, nature underlying link remains unclear. In this study, we investigated whether mild induces morphological, inflammatory, metabolic changes in retina resembling those seen glaucoma using rat model known as chronic hypoxia (CIH). Rats were randomly assigned to either normoxic CIH groups. The group was exposed periodic during its phase with oxygen reduction from 21% 10% reoxygenation 6 min cycles over 8 h/day. eyes subsequently enucleated, then retinas evaluated for retinal ganglion cell number, oxidative stress, inflammatory markers, changes, hypoxic response modulation immunohistochemistry, multiplex assays, capillary electrophoresis. Statistically significant differences observed groups stress inflammation, resulting increased HIF-1α protein levels, higher marker 8-OHdG, TNF-α. Pyruvate dehydrogenase kinase-1 significantly reduced CIH. No found number. Our findings suggest that upregulation retina, akin early-stage glaucoma.

Language: Английский

Citations

4
Extracellular Vesicles and Glaucoma: Opportunities and Challenges DOI
Mofazzal Hossain, Yutao Liu

Current Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: Feb. 3, 2025

Purpose Glaucoma is one of the leading causes irreversible blindness, characterized by progressive visual field loss. Several risk factors are associated with developing disease. However, exact mechanisms or pathological pathways involved still unknown. There an urgent need to find and biomarkers for early detection therapy halt progression cure Extracellular vesicles (EVs), specifically exosomes, have emerged as a crucial player in all aspects glaucoma, including pathogenesis therapeutic application their cell-cell communication properties.

Language: Английский

Citations

0
Features of toll-like receptor genes (TLR-2, TLR-3, TLR-4 and TLR-6) polymorphism in open-angle glaucoma patients DOI Creative Commons
А. В. Шевченко,

V. F. Prokofiev,

В. И. Коненков

et al.

Vavilov Journal of Genetics and Breeding, Journal Year: 2025, Volume and Issue: 29(1), P. 128 - 134

Published: March 4, 2025

Modern research shows that innate immunity plays an important role in the pathogenesis of primary open-angle glaucoma (POAG). An increase content toll-like receptors (TLR) glaucomatous retina human eye was revealed. TLRs can modulate immune response glaucoma; provide early recognition damaging agents, activation signaling pathways and effector mechanisms nonspecific defense system aimed at restoring homeostasis. The TLR-encoding genes’ polymorphism alters amino acid structure receptors, which leads to changes their functions: expression level, ligand-binding coreceptor functions, transport signal transmission. aim analyze association TLR2 (rs5743708), TLR3 (rs3775291), TLR4 (rs4986790, rs4986791) TLR6 (rs5743810) polymorphisms with patients Western Siberia. Methods: 99 (52 men 47 women) a diagnosis were examined. comparison group consisted 100 people (81 women 19 men). analyzed by RT-PCR using test systems Syber Green (Lytex, Russia). Statistical analysis performed software package SPSS 23.0 Arlequin 3.5.2.2. Results: distribution genotypes patient control corresponded Hardy–Weinberg equilibrium. genotype frequencies did not significantly differ between two groups. frequency TLR2-753 ArgArg:TLR6-249 ProPro increased POAG. linkage disequilibrium polymorphic positions gene In addition, TLR2-TLR6 for Conclusion: certain relative may indirectly indicate involvement infectious factors initiation However, despite proven importance participation protein products glaucoma, relationship TLR requires additional taking into account ethnic characteristics intergenic interactions better understanding complex disease development. This will help carry out develop necessary therapeutic strategy.

Language: Английский

Citations

0
The action of 7,8-dihydroxyflavone preserves retinal ganglion cell survival and visual function via the TrkB pathway in NMDA-induced retinal excitotoxicity DOI
Alejandro Gallego‐Ortega, Caridad Galindo‐Romero, Beatriz Vidal‐Villegas

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 185, P. 117944 - 117944

Published: March 8, 2025

Language: Английский

Citations

0
Enhanced in vivo performance of topical ocular acetazolamide nanocrystals: A novel approach for glaucoma treatment DOI
Hamoudi Ghassan Awde Alfonso, Luis Ignacio Tártara, Alejandro J. Paredes

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125440 - 125440

Published: March 1, 2025

Language: Английский

Citations

0
Retinoid X receptor agonist 9CDHRA mitigates retinal ganglion cell apoptosis and neuroinflammation in a mouse model of glaucoma DOI Creative Commons
Devaraj Basavarajappa, Nitin Chitranshi, Shahab Mirshahvaladi

et al.

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(6)

Published: March 13, 2025

Abstract Glaucoma, a leading cause of irreversible blindness, is characterized by the progressive loss retinal ganglion cells (RGCs) and optic nerve damage, often associated with elevated intraocular pressure (IOP). Retinoid X receptors (RXRs) are ligand‐activated transcription factors crucial for neuroprotection, as they regulate gene expression to promote neuronal survival via several biochemical networks reduce neuroinflammation. This study investigated therapeutic potential 9‐cis‐13,14‐dihydroretinoic acid (9CDHRA), an endogenous retinoid RXR agonist, in mitigating RGC degeneration high‐IOP‐induced experimental model glaucoma. We administered 9CDHRA glaucomatous mice eyes intravitreal injections assessed its effects on endoplasmic reticulum (ER) stress markers, glial cell activation, survival. Our findings demonstrated that treatment significantly protected inner function laminar structure high‐IOP The reduced ER increased protein lysine acetylation, diminished significant decrease apoptotic under conditions. These results suggest exerts neuroprotective modulating key pathogenic pathways glaucoma, highlighting novel strategy preserving vision

Language: Английский

Citations

0
TRPA1 exacerbates selective retinal ganglion cell vulnerability under acute ocular hypertension DOI Creative Commons
Wenhan Lu, Yu Wang, Wei Hu

et al.

Acta Neuropathologica Communications, Journal Year: 2025, Volume and Issue: 13(1)

Published: April 5, 2025

Language: Английский

Citations

0
Lycium barbarum glycopeptide promotes neuroprotection in ET-1 mediated retinal ganglion cell degeneration DOI Creative Commons

Yamunadevi Lakshmanan,

Francisca Siu Yin Wong,

Kwok–Fai So

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 5, 2024

Abstract Background Vascular dysregulation is one of the major risk factors glaucoma, and endothelin-1 (ET-1) may have a role in pathogenesis vascular-related glaucoma. Fruit extract from Lycium Barbarum (LB) exhibits anti-ageing multitarget mechanisms protecting retinal ganglion cells (RGC) various animal models. To investigate therapeutic efficacy LB glycoproteins (LbGP) ET-1 induced RGC degeneration, LbGP was applied under pre- posttreatment conditions to an mouse model. Retina structural functional outcomes were characterised using clinical-based techniques. Methods Adult C57BL/6 mice randomly allocated into four experimental groups, namely vehicle control ( n = 9), LbGP-Pretreatment 8), LbGP-Posttreatment (day 1) 8) 5) 7). Oral administration 1 mg/Kg or PBS for given once daily. Pre- commenced at week before 5 days after intravitreal injections, respectively, continued until postinjection day 28. Effects treatment on structure functions evaluated optical coherence tomography (OCT), doppler OCT electroretinogram measurements baseline, post-injection 10 survival by RBPMS immunostaining wholemounts. Results injection transient reductions arterial flow functions, leading significant RNFL thinning loss Although blood all treatments facilitated better restoration as compared with control. Also, three groups (i.e. posttreatments significantly preserved thRNFL thickness densities. No difference protective effects observed among groups. Conclusion demonstrated neuroprotective model either pretreatment, immediate delayed posttreatment. promoted flow, protected RNFL, density functions. This study showed translational potential complementary glaucoma management.

Language: Английский

Citations

2
Evaluation of Reporting Quality of Glaucoma Randomized Controlled Trial Abstracts: Current Status and Future Perspectives DOI Creative Commons

Ana Vučinović,

Josipa Bukić, Doris Rušić

et al.

Life, Journal Year: 2024, Volume and Issue: 14(1), P. 117 - 117

Published: Jan. 12, 2024

The aim of this study was to explore adherence the Consolidated Standards Reporting Trials (CONSORT) reporting standards in abstracts randomized controlled trials on glaucoma. A cross-sectional observational conducted aforementioned abstracts, indexed MEDLINE/PubMed between years 2017 and 2021. In total, 302 met inclusion criteria were further analyzed. median score CONSORT-A items 8 (interquartile range, 7-10) out 17 (47.0%). Most analyzed studies a single center (80.5%) predominantly structured (95.0%). Only 20.5% adequately described trial design, while randomization funding by 6.0% abstracts. Higher overall scores associated with multicenter setting, statistically significant results, industry, higher number participants, having been published journals impact factors above four (

Language: Английский

Citations

1
Piezo1 and Piezo2 channels in retinal ganglion cells and the impact of Piezo1 stimulation on light-dependent neural activity DOI Open Access
Puttipong Sripinun, Lily Pachanin See,

Sergei Nikonov

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 25, 2024

Piezo channels are associated with neuropathology in diseases like traumatic brain injury and glaucoma, but pathways linking tissue stretch to aberrant neural signaling remain unclear. The present study demonstrates that Piezo1 activation increases action potential frequency response light the spontaneous dark signal from mouse retinal explants. stimulation was sufficient increase cytoplasmic Ca

Language: Английский

Citations

1