Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Oct. 17, 2024
Systemic
sclerosis
(SSc)
is
a
complex
autoimmune
disease
with
clinical
symptoms
of
vascular
damage,
immune
disorders,
and
fibrosis,
presenting
significant
treatment
challenges
limited
therapeutic
options.
Mesenchymal
stem
cell-derived
extracellular
vesicles
(MSC-EVs)
have
been
demonstrated
in
numerous
studies
as
more
effective
than
MSCs
treating
diseases.
Recent
demonstrate
that
MSC-EVs
can
significantly
ameliorate
the
SSc
mitigate
pathological
changes
such
injury,
dysregulation,
fibrosis.
These
findings
underscore
promising
potential
SSc.
promote
angiogenesis,
modulate
dysfunction,
combat
This
article
summarizes
applications
possible
mechanisms
for
SSc,
thereby
offering
novel
direction
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 4, 2024
Abstract
Skin
fibrosis
is
a
progressive
pathologic
outcome
of
prolonged
healing
cutaneous
wound
which
has
been
well
accepted
as
metabolic
disease
in
recent
study.
However,
the
impact
ketone
body
metabolism
on
development
remains
largely
unknown.
Here,
we
found
that
was
impaired
both
human
scars
and
bleomycin
induced
skin
fibrogenesis
mouse
by
bioinformatics
analysis,
further
evidenced
downregulated
expression
key
modulators
including
BDH1,
OXCT1,
ACAT1.
With
knockdown
spontaneous
onset
normal
exacerbation
observed.
In
dermal
fibroblasts
treated
with
TGF-β1,
OXCT1
improved
their
phenotype
transition
to
myofibroblasts.
Mechanistic
studies
indicated
phosphorylation
Smad2/3
signaling
markedly
suppressed
acetoacetate
(AcAc)
supplementation.
More
importantly,
local
administration
remarkably
alleviated
mouse.
Thus,
our
findings
underscore
therapeutic
potential
AcAc
an
alternative
intervention
for
fibrosis.
