Food Bioscience, Journal Year: 2024, Volume and Issue: 63, P. 105666 - 105666
Published: Dec. 10, 2024
Language: Английский
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 9, 2025
Oxidative stress (OS) is established as a key factor in the etiology of both male and female infertility, arising from an imbalance between reactive oxygen species (ROS) production endogenous antioxidant (AOX) defenses. In men, OS adversely affects sperm function by inducing DNA damage, reducing motility, significantly impairing vitality through plasma membrane peroxidation loss integrity, ultimately compromising overall quality. women, implicated various reproductive disorders, including polycystic ovary syndrome, endometriosis, premature ovarian failure, leading to diminished oocyte quality, disrupted folliculogenesis, poorer outcomes. Antioxidant therapy represents promising intervention mitigate harmful effects ROS on health additions its easy accessibility, safety, low cost. Despite several findings suggesting improvements fertility potential with AOX therapy, data remains inconclusive regarding optimal dosage combination, duration treatment, specific patient populations most likely benefit. this review, we discuss role AOXs management infertile couples, focusing their biological mechanisms, adverse effects, therapeutic efficacy, clinical applications improving outcomes natural conception medically assisted reproduction. Additionally, highlight current practice patterns recommendations for supplementation during course infertility treatment. Further, provide overview limitations research topic insights future studies establish standardized regimens assess long-term impact such live birth rates miscarriage rates.
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 739 - 739
Published: Jan. 16, 2025
The ability to reproduce depends on metabolic status. In rodents, the ventral premammillary nucleus (PMv) integrates and reproductive signals. While leptin (adiposity-related) signaling in PMv is critical for female fertility, male functions are strongly influenced by glucose homeostasis. anorexigenic peptide nesfatin-1 a leptin-independent central regulator of blood glucose. Therefore, its integrative role rats can be assumed. To investigate this, we mapped distribution mRNA- protein-producing cells during postnatal development via situ hybridization immunohistochemistry, respectively. Fos-nesfatin-1, double immunostaining was used determine combined effect heterosexual pheromone challenge insulin-induced hypoglycemia neuronal activation adults. We found that ~75% pheromone-activated neurons were cells. Hypoglycemia reduced pheromone-induced cell activation, particularly neurons. Immuno-electron microscopy revealed innervation urocortin3-immunoreactive terminals, reportedly originating from medial amygdala. Nesfatin-1 immunopositive expressed GPR10 mRNA, receptor associated with signaling, but did not respond accumulation phosphorylated STAT3 immunopositivity, marker response intracerebroventricular treatment. Our results suggest primarily responsible integrating rats.
Language: Английский
Citations
1
iScience, Journal Year: 2025, Volume and Issue: 28(3), P. 112110 - 112110
Published: Feb. 26, 2025
Language: Английский
Citations
0
Arab Journal of Urology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 8
Published: March 5, 2025
Obesity is a common health problem affecting over third of the population worldwide. has been correlated with many diseases, including cardiovascular disorders, diabetes, cancer, brain degeneration, and premature aging. In men, obesity can also cause issues like erectile dysfunction, poor sperm quality, prostate problems. Factors high insulin levels, chronic inflammation, oxidative stress may play role in how affects male fertility. disrupt reproductive system by changing hormone production, causing problems metabolism. This result reduction count, motility, normal forms. DNA fragmentation, increase cell death, impact genetic information that be passed on to future generations. narrative review explores impacts fertility, as well possible treatment options weight management, lifestyle changes, medications, alternative therapies.
Language: Английский
Citations
0
Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 950 - 950
Published: March 8, 2025
Background/Objectives: Lifestyle factors, sociodemographic determinants, and dietary patterns play an important role in shaping genitors fetal health. This study aimed to identify investigate the social determinants of health lifestyle components associated with body mass index (BMI) a population reproductive age. Methods: A cross-sectional online survey was conducted between March 2021 February 2022. Self-reported data on age, weight, height, medical history were collected. Results: total 284 participants age (≤40 years age) included analysis. We identified 3 main patterns: (1) Prudent pattern, higher probability eating meals/day, longer jetlag being homemaker, unemployed, or student; (2) Western after 9 p.m., negatively employment status (i.e., student); (3) Unhealthy smoker. Furthermore, using multivariate linear regression, we found that BMI living rural area adopting pattern. For adherence it smoking men > women, significant interaction gender (p < 0.001). Conclusions: These could be helpful implementing personalized educational interventions nutrition changes tailored for risk categories order improve people
Language: Английский
Citations
0
Metabolites, Journal Year: 2025, Volume and Issue: 15(4), P. 267 - 267
Published: April 11, 2025
Inflammation, infections, and oxidative stress (OS) all have an impact on male infertility, which is a complicated, multifaceted illness. OS affects motility fertilization capability. It accomplishes this through damaging sperm DNA, oxidizing proteins, triggering lipid peroxidation. These effects occur due to imbalance between reactive oxygen species (ROS) antioxidant defenses. This review aims evaluate the of inflammation infertility by assessing recent literature. Pro-inflammatory cytokines, like TNF-α IL-6, interfere with spermatogenesis promote damage. Additionally, infections caused pathogens Escherichia coli Chlamydia trachomatis alter reproductive microenvironment, leading dysfunction inflammation. Early detection targeted treatment are essential intricate interactions among these elements. Microbiota-modulating techniques, antimicrobial therapies, anti-inflammatory drugs, antioxidants therapeutic approaches that may help reduce damage enhance fertility.
Language: Английский
Citations
0
Essays in Biochemistry, Journal Year: 2024, Volume and Issue: 68(3), P. 349 - 361
Published: Aug. 23, 2024
Abstract Obesity is a major risk factor for many life-threatening diseases. Adipose tissue dysfunction emerging as driving in the transition from excess adiposity to comorbidities such metabolic-associated fatty liver disease, cardiovascular Type 2 diabetes and cancer. However, healthy adipose expansion development of these conditions poorly understood. stem cells, residing vasculature stromal regions subcutaneous visceral depots, are responsible maintenance organ function, now recognised key mediators pathological transformation. Impaired drives inflammation, dysregulation endocrine function deposition lipids liver, muscle around vital organs, where it toxic. Contrary previous hypotheses, promotion not inhibition adipogenesis, that presents most attractive therapeutic strategy treatment metabolic disease. AMP-activated protein kinase, master regulator energy homeostasis, has been regarded one target, due its central role lipid metabolism, apparent adipogenesis. recent studies utilising kinase (AMPK)-specific compounds highlight more subtle, time-dependent AMPK process previously unexplored repression leptin, independent adipocyte maturity. In this article, I discuss historic evidence AMPK-mediated adipogenesis multi-faceted roles tissue.
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4089 - 4089
Published: April 25, 2025
Because male obesity may result in reproductive failure, we aimed to examine the possible links among body mass index (BMI), waist–hip ratio (WHR), and basic semen parameters, oxidation–reduction potential of semen, total antioxidant capacity seminal plasma, ability sperm bind hyaluronic acid, DNA fragmentation (SDF). This study was performed on (n = 543) collected from volunteers classified as follows: normal weight (BMI 18.5–24.9 kg/m2), overweight 25.0–29.9 obese ≥ 30.0 with a WHR (<1) or abnormal (≥1). No significant differences standard parameters were found between men BMI those overweight/obesity. However, compared men, had higher SDF prevalence risk for an > 20%. Compared < 1, 1 significantly lower motility, morphology, vitality increased index, In conclusion, greater negative impact conventional than BMI. Both negatively influenced chromatin integrity only. Obesity is factor damage.
Language: Английский
Citations
0
Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 103 - 103
Published: Dec. 30, 2024
Background/Aim: Subfertility is characterized by a decrease in reproductive efficiency, which can result delayed pregnancy, and affects one six individuals during their lifetime. The present narrative review aims to evaluate the contribution of precision nutrition changes fertility subfertile couples. Methods: literature was carried out through bibliographic research PubMed, Scopus, SciELO Google Scholar databases. following search criteria were applied: (1) original articles narrative, systematic or meta-analytic reviews, (2) individual combined use keywords: “genetic variation”, “nutrigenetics”, “precision nutrition”, “couple’s subfertility”, infertility”. A preliminary reading all out, only those that best fit themes subthemes selected. Results: Scientific evidence suggests adherence healthy diet follows Mediterranean pattern associated with increased women improved semen quality men, better metabolic health reduced levels inflammation oxidative stress, as well maintaining body weight. integration different tools, such nutrigenetics, predictive biochemical analyses, intestinal microbiota tests clinical software, used interventions contribute providing information on how genetics interact they influence fertility. Conclusions: adoption multidisciplinary approach allows design dietary lifestyle recommendations adapted specific characteristics needs couples subfertility, thus optimizing outcomes achieving successful conception.
Language: Английский
Citations
1
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: July 2, 2024
Language: Английский
Citations
0