Impact of Sub-Chronic Exposure to Kalach on male reproductive system and sperm function: In Silico Modelling and In Vivo Study in Rats

Reproductive Toxicology, Journal Year: 2025, Volume and Issue: 132, P. 108853 - 108853

Published: Feb. 6, 2025

Language: Английский

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Experimental exposure of bivalves (Ruditapes decussatus) and meiobenthos (Metoncholaimus pristiurus) to 2,2′4,4′-tetrabromodiphenyl ether (PBDE-47) assessed by biochemical, computational modeling, and microbial tools

Marine Pollution Bulletin, Journal Year: 2024, Volume and Issue: 209, P. 117191 - 117191

Published: Nov. 1, 2024

Language: Английский

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Exploring the effects of decabromodiphenyl ether on meiofaunal communities: An experimental approach

Marine Pollution Bulletin, Journal Year: 2025, Volume and Issue: 214, P. 117762 - 117762

Published: March 6, 2025

Language: Английский

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Neuroprotective and antioxidant effects of Urtica dioica extract against chlorpyrifos-induced toxicity: an in vivo study

3 Biotech, Journal Year: 2025, Volume and Issue: 15(4)

Published: March 12, 2025

Language: Английский

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Assessment of the effects of paroxetine and zinc on crustaceans through integrated quantitative and taxon/functional tools with a focus on free-living marine copepods and amphipods

Marine Pollution Bulletin, Journal Year: 2025, Volume and Issue: 215, P. 117887 - 117887

Published: March 30, 2025

Language: Английский

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Polydatin attenuates Alzheimer’s disease induced by aluminum chloride in rats: evidence for its antioxidant and anti-inflammatory effects

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

Background Considering the complex pathophysiological mechanisms behind Alzheimer’s disease (AD), a few drugs for managing related cognitive symptoms have been approved. The phytochemical resveratrol has shown promising anti-inflammatory and antioxidant effects in AD, but it low bioavailability. Chemical modification of to its glycosylated form, polydatin (PD), significantly increases bioavailability bioactivity. Purpose study aimed investigate therapeutic potential action PD against AD rats. Material method was caused by an intraperitoneal (i.p.) administration aluminum chloride (AlCl 3 ). Six groups six rats each were defined as sham, negative control ), positive (Donepezil), treatments (PD 5, 10, 20 mg/kg, i.p.). On days 7, 8, 14, 15, rats’ behavioral changes assessed open field, Y-maze test, passive avoidance elevated plus maze tests. At end study, blood samples collected assess levels glutathione (GSH), catalase (CAT), nitrite, well activity matrix metalloproteinases (MMPs). Furthermore, hippocampal brain tissue removed used histological investigations. Results discussion findings revealed that injections at three different doses (5, mg/kg) improved other impairments. capacity increasing GSH CAT while decreasing serum nitrite levels. showed reducing inflammatory MMP-9, elevating MMP-2. also modulated pathogenic tissue. Conclusion alleviated impairments enhancing defenses neuroinflammation.

Language: Английский

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Impact of climate change on the toxicity of bisphenol A in Mytilus galloprovincialis and assessment of phycoremediation using Nannochloropsis salina via a multi-biomarker strategy and modeling

Marine Pollution Bulletin, Journal Year: 2025, Volume and Issue: 216, P. 118010 - 118010

Published: April 19, 2025

Language: Английский

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Effects of antibiotics and metals on meiofauna assessed through taxon/functional and modeling tools: a case study of amoxicillin and copper

Marine Pollution Bulletin, Journal Year: 2025, Volume and Issue: 216, P. 118022 - 118022

Published: April 19, 2025

Language: Английский

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Evaluation of the Pro-Angiogenic Effect in Chicken Embryo Chorioallantoic Membrane (CAM) Model and the In Vivo Wound Healing Potential of the Moroccan Polysaccharide-Rich Algae Osmundea pinnatifida

Published: Oct. 23, 2024

Various methods have been studied to speed up the wound healing process. Promoting rapid development of blood vessels, also known as angiogenesis, is essential this significantly accelerates skin regeneration. This study identified a polysaccharide from red alga Osmundea pinnatifida (PSOP) that promotes angiogenesis and healing. Firstly, we analyzed structural characteristics PSOP using various techniques such UV-visible spectrum, Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffraction (X-RD), scanning electron microscopy (SEM), high-performance liquid chromatography coupled refractive index detector (HPLC-RID). We evaluated antioxidant properties in vitro tests for DPPH free radical scavenging capacity, iron reduction capacity (RPA), total (TAC). Additionally, observed significant increase new vessel formation chorioallantoic membrane model (CAM assay) fertilized hen egg, indicating pro-angiogenic effect PSOP. Furthermore, tested wound-healing potential hydrogel vivo excision wounds Wistar rat model. The results showed notable acceleration closure an improvement tissue regeneration collagen deposition quality within 11 days, strong activity Our computational suggested units bind cyclooxygenase 2 (COX-2) vascular endothelial growth factor (VEGF) with acceptable affinities interactions, which might explain beneficial seen experimental assays. findings support treatment due its potential.

Language: Английский

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Are irbesartan and losartan ecotoxic for free-living marine nematodes? Response elements from taxonomic and functional features

Regional Studies in Marine Science, Journal Year: 2024, Volume and Issue: 81, P. 103934 - 103934

Published: Nov. 26, 2024

Language: Английский

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