A Nanorobotics-Based Approach of Breast Cancer in the Nanotechnology Era DOI Open Access

Anca-Narcisa Neagu,

Taniya Jayaweera,

Krishan Weraduwage

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4981 - 4981

Published: May 2, 2024

We are living in an era of advanced nanoscience and nanotechnology. Numerous nanomaterials, culminating nanorobots, have demonstrated ingenious applications biomedicine, including breast cancer (BC) nano-theranostics. To solve the complicated problem BC heterogeneity, non-targeted drug distribution, invasive diagnostics or surgery, resistance to classic onco-therapies real-time monitoring tumors, nanorobots designed perform multiple tasks at a small scale, even organelles molecular level. Over last few years, most been bioengineered as biomimetic biocompatible nano(bio)structures, resembling different organisms cells, such urchin, spider, octopus, fish, spermatozoon, flagellar bacterium helicoidal cyanobacterium. In this review, readers will be able deepen their knowledge structure, behavior role several types among other theranostics. summarized here characteristics many functionalized nanodevices counteract main neoplastic hallmark features BC, from sustaining proliferation evading anti-growth signaling resisting programmed cell death inducing angiogenesis, activating invasion metastasis, preventing genomic instability, avoiding immune destruction deregulating autophagy. Most these function targeted self-propelled smart nano-carriers nano-drug delivery systems (nano-DDSs), enhancing efficiency safety chemo-, radio- photodynamic therapy, current imagistic techniques used diagnosis. tested vitro, using various lines, well vivo, mainly based on mice models. still waiting for that low-cost, wider transition favorable effects laboratory clinical practice.

Language: Английский

SwarmRL: building the future of smart active systems DOI Creative Commons
Samuel Tovey, Christoph Lohrmann,

Tobias Merkt

et al.

The European Physical Journal E, Journal Year: 2025, Volume and Issue: 48(4-5)

Published: April 7, 2025

This work introduces SwarmRL, a Python package designed to study intelligent active particles. SwarmRL provides an easy-to-use interface for developing models control microscopic colloids using classical and deep reinforcement learning approaches. These may be deployed in simulations or real-world environments under common framework. We explain the structure of software its key features demonstrate how it can used accelerate research. With we aim streamline research into micro-robotic while bridging gap between experimental simulation-driven sciences. is available open-source on GitHub at https://github.com/SwarmRL/SwarmRL .

Language: Английский

Citations

0

A review of magnetically driven swimming microrobots: Material selection, structure design, control method, and applications DOI Creative Commons
Huibin Liu,

Qinghao Guo,

Wenhao Wang

et al.

REVIEWS ON ADVANCED MATERIALS SCIENCE, Journal Year: 2023, Volume and Issue: 62(1)

Published: Jan. 1, 2023

Abstract Magnetically driven swimming microrobot is a typical one in the family of microrobots and they can achieve navigation manipulation low Reynolds number biomedical environments with an external magnetic drive strategy. This study reviews recent advances material selection, structure design, fabrication techniques, control method, applications for magnetically microrobots. First, materials used were introduced effect selection on performance was discussed. Second, design manufacturing techniques are reviewed, followed by discussion main effective motion control, path planning, tracking. Then, multi-applications including targeted drug delivery, cell manipulation, minimally invasive surgery summarized. Finally, current challenges future directions work

Language: Английский

Citations

9

Promising advances in physically propelled micro/nanoscale robots DOI Creative Commons

Zishang Liang,

Baolei Zhang, Shenghui Yi

et al.

Nano Materials Science, Journal Year: 2024, Volume and Issue: unknown

Published: June 1, 2024

Micro/nanoscale robots (MNRs) have attracted significant interest in various fields because of their flexible design, physically controlled maneuvering, and barrier targeting. The execution specific functions using MNRs relies on precise propulsion methods. Among the diverse techniques, physical is widely used owing to its noninvasive, safe, convenient attributes. This review provides an analysis mechanisms magnetic, electric, thermal, ultrasound presents a comprehensive summary structures, movements, applications while also examining advantages shortcomings associated with Finally, challenges perspectives future development are presented. content this can serve as multidisciplinary science reference for physicists, bioengineers, clinicians, roboticists, chemists involved pharmaceutical design clinical therapy research.

Language: Английский

Citations

3

On‐Command Disassembly of Microrobotic Superstructures for Transport and Delivery of Magnetic Micromachines DOI Creative Commons
Fabian C. Landers, Valentin Gantenbein,

Lukas Hertle

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(18)

Published: Dec. 16, 2023

Abstract Magnetic microrobots have been developed for navigating microscale environments by means of remote magnetic fields. However, limited propulsion speeds at small scales remain an issue in the maneuverability these devices as force and torque are proportional to their volume. Here, a microrobotic superstructure is proposed, which, analogous supramolecular system, consists two or more units that interconnected organized through physical (transient) component (a polymeric frame thread). The superstructures consist microfabricated helical micromachines interlocked gelatin nanocomposite containing iron oxide nanoparticles (IONPs). While microhelices enable motion superstructure, IONPs serve heating transducers dissolving chassis via hyperthermia. In practical demonstration, superstructure's with gradient field large channel, disassembly release high‐frequency alternating field, corkscrew locomotion released helices channel rotating showcased. This adaptable reacts different inputs, which can be used perform complex delivery procedures within intricate regions human body.

Language: Английский

Citations

8

A Nanorobotics-Based Approach of Breast Cancer in the Nanotechnology Era DOI Open Access

Anca-Narcisa Neagu,

Taniya Jayaweera,

Krishan Weraduwage

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4981 - 4981

Published: May 2, 2024

We are living in an era of advanced nanoscience and nanotechnology. Numerous nanomaterials, culminating nanorobots, have demonstrated ingenious applications biomedicine, including breast cancer (BC) nano-theranostics. To solve the complicated problem BC heterogeneity, non-targeted drug distribution, invasive diagnostics or surgery, resistance to classic onco-therapies real-time monitoring tumors, nanorobots designed perform multiple tasks at a small scale, even organelles molecular level. Over last few years, most been bioengineered as biomimetic biocompatible nano(bio)structures, resembling different organisms cells, such urchin, spider, octopus, fish, spermatozoon, flagellar bacterium helicoidal cyanobacterium. In this review, readers will be able deepen their knowledge structure, behavior role several types among other theranostics. summarized here characteristics many functionalized nanodevices counteract main neoplastic hallmark features BC, from sustaining proliferation evading anti-growth signaling resisting programmed cell death inducing angiogenesis, activating invasion metastasis, preventing genomic instability, avoiding immune destruction deregulating autophagy. Most these function targeted self-propelled smart nano-carriers nano-drug delivery systems (nano-DDSs), enhancing efficiency safety chemo-, radio- photodynamic therapy, current imagistic techniques used diagnosis. tested vitro, using various lines, well vivo, mainly based on mice models. still waiting for that low-cost, wider transition favorable effects laboratory clinical practice.

Language: Английский

Citations

2