Gels,
Journal Year:
2025,
Volume and Issue:
11(5), P. 343 - 343
Published: May 6, 2025
Janus
hydrogels,
distinguished
by
their
dual-sided
structure
with
distinct
physical
and
chemical
properties,
have
garnered
significant
attention
in
the
medical
field,
particularly
for
applications
drug
delivery,
tissue
engineering,
wound
healing.
Their
ability
to
simultaneously
perform
multiple
functions,
such
as
targeted
release
biomimetic
interaction,
positions
them
a
promising
platform
advanced
therapeutic
strategies.
The
growing
interest
these
hydrogels
is
primarily
driven
multifunctionality
capacity
address
complex
biological
needs.
This
review
delves
into
design,
fabrication
methods,
of
medicine,
focusing
on
potential
overcome
limitations
conventional
therapies
providing
comprehensive
overview
role
contemporary
biomedical
applications.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Jan. 12, 2024
Globally,
an
annual
count
of
more
than
two
million
bone
transplants
is
conducted,
with
conventional
treatments,
including
metallic
implants
and
grafts,
exhibiting
certain
limitations.
In
recent
years,
there
have
been
significant
advancements
in
the
field
regeneration.
Oxygen
tension
regulates
cellular
behavior,
which
turn
affects
tissue
regeneration
through
metabolic
programming.
Biomaterials
oxygen
release
capabilities
enhance
therapeutic
effectiveness
reduce
damage
from
hypoxia.
However,
precise
control
over
a
technical
challenge,
despite
its
potential
to
support
viability
differentiation.
The
matrices
often
used
repair
large-size
defects
do
not
supply
enough
stem
cells
being
process.
Hypoxia-induced
necrosis
primarily
occurs
central
regions
large
due
inadequate
provision
nutrients
by
surrounding
vasculature
host
tissues.
generating
biomaterials
(OGBs)
are
becoming
increasingly
enhancing
our
capacity
facilitate
regeneration,
thereby
addressing
challenges
posed
hypoxia
or
vascularization.
Herein,
we
discussed
key
role
various
source
materials
their
mechanism
release,
fabrication
techniques
employed
for
oxygen-releasing
matrices,
novel
emerging
approaches
delivery
that
hold
promise
application
Molecules,
Journal Year:
2025,
Volume and Issue:
30(3), P. 615 - 615
Published: Jan. 30, 2025
Royal
jelly
and
medical
grade
honey
are
traditionally
used
in
treating
wounds
infections,
although
their
effectiveness
is
often
variable
insufficient.
To
overcome
limitations,
we
created
novel
amphiphiles
by
modifying
the
main
reparative
antimicrobial
components,
queen
bee
acid
(hda)
10-hydroxyl-decanoic
(hdaa),
through
peptide
bonding
with
specific
tripeptides.
Our
molecular
design
incorporated
amphiphile
targets
as
being
biocompatible
wound
healing,
biodegradable,
non-toxic,
hydrogelable,
prohealing,
antimicrobial.
The
amphiphilic
molecules
were
designed
a
hda(hdaa)-aa1-aa2-aa3
structural
model
rational
selection
criteria
for
each
moiety,
prepared
via
Rink/Fmoc-tBu-based
solid-phase
synthesis,
structurally
verified
NMR
LC–MS/MS.
We
tested
several
among
those
containing
moieties
of
hda
or
hdaa
isoleucine–leucine–aspartate
(ILD-amidated)
IL-lysine
(ILK-NH2).
These
tests
conducted
to
evaluate
prohealing
hydrogel
properties.
observation
hydrogelation
hydrogel-rheology
showed
that
they
can
form
hydrogels
stable
elastic
moduli
injectable
shear-thinning
properties,
which
suitable
cell
tissue
repair
regeneration.
disc-diffusion
assay
demonstrated
hdaa-ILK-NH2
markedly
inhibited
Staphylococcus
aureus.
Future
research
needed
comprehensively
properties
these
modified
from
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 3, 2024
Abstract
The
seamless
integration
of
emerging
directional
liquid
transport
(DLT)
technology
with
traditional
textile
materials
has
ushered
in
the
next‐generation
multifunctional
textiles,
i.e.,
DLT
which
will
play
a
vital
role
areas
such
as
wearable
smart
and
ecological
environmental
protection.
To
further
promote
combination
technology,
concise
overview
research
progress
including
basic
mechanisms,
various
preparation
strategies
diversified
applications
textiles
is
provided.
In
this
review,
theoretical
mechanisms
from
perspective
wetting
wicking
discussed.
Besides,
categorized
them
into
three
categories
summarized:
fiber‐based
fabric‐based
fiber/fabric
hybrid‐based
textiles.
Subsequently,
current
potential
are
classified
discussed,
mainly
focusing
on
functional
clothing,
oil‐water
separation,
fog
collection,
distillation,
sensors,
biomedicine,
so
on.
Finally,
challenges
prospects
to
enhance
functionality
application
performance
outlined.
Materials & Design,
Journal Year:
2023,
Volume and Issue:
237, P. 112567 - 112567
Published: Dec. 10, 2023
Excessive
biofluid
around
wounds
can
cause
infection
and
prevent
healing.
In
this
study,
an
anisotropic
quaternized
chitosan
(QC)/sodium
alginate
(AL)-based
aerogel
wound
dressing
was
prepared
via
a
directional
freeze-drying
technique
inspired
by
the
channel
structure
used
for
water
transport
in
trees.
The
aligned
channels
provided
with
self-pumping
ability,
allowing
it
to
rapidly
completely
remove
biofluids
absorb
up
1292.5%
of
its
own
weight.
To
enhance
strength
dressing,
double
cross-linked
network
constructed
based
on
QC-AL
electrostatic
attraction
AL-Ca2+
chelation
interaction.
axial
compressive
reached
207.3
kPa
(ε
=
50%).
addition,
exhibited
strong
conductive
properties
(conductivity
13.0
S/m),
antioxidant
activities
[reactive
oxygen
species
(ROS)
scavenging
ability
88.0%],
hemostatic
characteristics
(blood
coagulation
index
1.8%).
also
powerful
antibacterial
performance,
exhibiting
over
98.0%
inhibition
E.
coli
S.
aureus.
Experiments
diabetic
mouse
models
revealed
that
considerably
promoted
On
day
3,
healing
rate
96.7%
faster
QAC
group
than
gauze
group.
Therefore,
developed
may
have
great
potential
chronic
care.
