Engineering Ga-doped mesoporous bioactive glass-integrated PEEK implants for immunomodulatory and enhanced osseointegration effects DOI Creative Commons

Shiran Zhou,

Zubo Tu,

Zhigang Chen

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114189 - 114189

Published: Aug. 29, 2024

With the increasing aging population, demand for orthopedic implants is also growing. Polyether ether ketone (PEEK) considered a promising material due to its excellent biocompatibility. However, lack of bioactivity and excessive immune response post-implantation often impair bone integration. Therefore, it urgent bio-functionalize PEEK-based promote This study employs simple, economical, feasible method coat Ga-ion doped bioactive glass nanoparticles (Ga-MBGs) onto sulfonated PEEK surfaces, constructing multifunctional implant. The resulting bio-functionalized macrophage M2 phenotype polarization, thus fostering an anti-inflammatory microenvironment. Moreover, direct osteogenic effect Ga ions immuno-osteogenic through promoting polarization enhance differentiation potential in vitro integration vivo. A sequence vivo experiments substantiates essential intricate function this innovative implants. regulating normal immunity metabolism. Overall, application Ga-MBGs provides effective developing surface implant, capable modulating metabolism, holds significant clinical as

Language: Английский

Chitosan‐Modified Hydrogel Microsphere Encapsulating Zinc‐Doped Bioactive Glasses for Spinal Cord Injury Repair by Suppressing Inflammation and Promoting Angiogenesis DOI

Xin‐Jin Su,

Changjiang Gu,

Ziheng Wei

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Spinal cord injury (SCI) is a common nerve caused by external force, resulting in sensory and motor impairments. Previous studies demonstrated that inhibiting the neuroinflammation promoted SCI repair. However, these approaches are low efficient, lack targeting specificity, even require repeated high doses of systemic administration. To address such issues, present study, chitosan-modified hydrogel microspheres encapsulating with zinc-doped bioactive glasses (CS-MG@Zn/BGs) constructed for targeted repair SCI. In vitro, CS-MG@Zn/BGs effectively inhibited acute inflammatory response initiated microglia angiogenic activities. vivo, injured site, attenuated infiltration modulating polarization toward M2 type. Furthermore, it facilitated vascular reconstruction, neuronal differentiation, axonal regeneration remyelination at thereby function recovery mice. The vitro vivo results implied may be promising alternative rehabilitation

Language: Английский

Citations

4
Functional poly(ether-ketone-ketone) composite scaffold with enhanced cell-material interaction, anti-inflammatory and osteogenesis for facilitating osteointegration and bone regeneration DOI Creative Commons

Qianwen Yang,

Anbei Chen,

Xin Zhang

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101533 - 101533

Published: Jan. 29, 2025

Bone defects resulting from trauma or disease remain a significant challenge in clinical practice, often requiring prolonged treatment. Poly(ether-ketone-ketone) (PEKK) is commonly used implant material due to its excellent biocompatibility and mechanical properties, which are similar those of bone. However, biological inertness leads poor anti-inflammatory osteointegration significantly hindering the bone repair process. In this study, cryogel filled - PEKK/bioglass (BG) composite scaffold (SPBC) was prepared via 3D printing provide immunomodulatory integration performance. Compared with untreated PEKK, SPBC exhibited enhancements surface including higher hydrophilicity roughness. Additionally, enhanced adsorption fibronectin vitronectin on regulated maturation cytoskeleton adhesion plaques by increasing phosphorylation level FAK at Y397, thereby promoting cell spreading. Due release bioactive ions, can promote polarization RAW264.7 cells towards M2 secretion cytokines, while also enhancing proliferation differentiation rat mesenchymal stem (rMSCs) vitro. Furthermore, vivo results confirmed properties host tissue. summary, after modification filling, demonstrated abilities, presenting potential for application as an orthopedic scaffold.

Language: Английский

Citations

0
Material‐Mediated Immunotherapy to Regulate Bone Aging and Promote Bone Repair DOI Open Access

Pengfei Xue,

Jiayi Wang, Yu Fu

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Abstract As the global population ages, an increasing number of elderly people are experiencing weakened bone regenerative capabilities, resulting in slower repair processes and associated risks various complications. This review outlines research progress on biomaterials that promote through immunotherapy. examines how manufacturing technologies such as 3D printing, electrospinning, microfluidic technology contribute to enhancing therapeutic effects these biomaterials. Following this, it provides detailed introductions anti‐osteoporosis drug delivery systems, injectable hydrogels, nanoparticles, engineered exosomes, well tissue engineering materials coatings used immunomodulation. Moreover, critically analyzes current limitations biomaterial‐mediated immunotherapy explores future directions for material‐mediated aims inspire new approaches broaden perspectives addressing challenges aging by exploring innovative strategies.

Language: Английский

Citations

0
Specific activation of cGAS-STING pathway by manganese-doped bioactive glasses for boosting systemic tumor immunotherapy DOI Creative Commons
Zhaolin Yang, Jiale Zhou, Xinrui Wu

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113764 - 113764

Published: Feb. 1, 2025

Language: Английский

Citations

0
Overcoming biological inertness: multifaceted strategies to optimize PEEK bioactivity for interdisciplinary clinical applications DOI

Yingjia Sun,

Shuai Ma, Yang Shi

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Polyether ether ketone (PEEK), characterized by a comparable elastic modulus to human bone with high wear resistance, radiolucency, and biocompatibility, demonstrates considerable promise for clinical applications.

Language: Английский

Citations

0
Micromotion‐Driven “Mechanical‐Electrical‐Pharmaceutical Coupling” Bone‐Guiding Membrane Modulates Stress‐Concentrating Inflammation Under Diabetic Fractures DOI
Junhao Sui,

Yijin Hou,

Chen Ding

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract The use of piezoelectric materials to convert micromechanical energy at the fracture site into electrical signals, thereby modulating stress‐concentrated inflammation, has emerged as a promising treatment strategy for diabetic fractures. However, traditional bone‐guiding membranes often face challenges in repair due their passive and imprecise drug release profiles. Herein, polyvinylidene fluoride (PVDF) fibrous membrane is fabricated through electrospinning oxidative polymerization load metformin (Met) polypyrrole (PPy) coating (Met‐PF@PPy), creating “mechanical‐electrical‐pharmaceutical coupling” system. In micromotion mechanical environment, Met‐PF@PPy converts activating electrochemical reduction PPy triggering stress‐responsive Met release. generated signals suppress inflammation M1‐to‐M2 macrophage polarization simultaneously enhance osteogenesis. Simultaneously, inhibits NF‐κB pathway reduce pro‐inflammatory cytokines while AMPK promote osteogenesis angiogenesis. mouse femoral model, significantly reduces inflammatory markers, enhances vascularization, increases bone mineral density volume fraction by over 30%. This “force‐electric‐drug provides an innovative approach active regulation offers versatile platform advancing regenerative medicine.

Language: Английский

Citations

0
Advances in harnessing biological macromolecules for periodontal tissue regeneration: A review DOI

Dongyi Yang,

Dong He, Fengkai Yang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144031 - 144031

Published: May 1, 2025

Language: Английский

Citations

0
Alternative to surface sulfonation: Biofunctionalizing PEEK surfaces via 3D porous coatings using the nonsolvent-induced phase separation approach DOI
Ming Xie, Zhang Shan,

Zhi-gang Song

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 164025 - 164025

Published: May 1, 2025

Language: Английский

Citations

0
Multifunctional hydrogel dressing promotes wound healing by reprogramming the infection-related wound microenvironment DOI

Yaqi Xi,

Shuo Zhang, Meng-Ru Wu

et al.

Journal of Materials Science, Journal Year: 2024, Volume and Issue: 59(35), P. 16660 - 16677

Published: Sept. 1, 2024

Language: Английский

Citations

2
Engineering Ga-doped mesoporous bioactive glass-integrated PEEK implants for immunomodulatory and enhanced osseointegration effects DOI Creative Commons

Shiran Zhou,

Zubo Tu,

Zhigang Chen

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114189 - 114189

Published: Aug. 29, 2024

With the increasing aging population, demand for orthopedic implants is also growing. Polyether ether ketone (PEEK) considered a promising material due to its excellent biocompatibility. However, lack of bioactivity and excessive immune response post-implantation often impair bone integration. Therefore, it urgent bio-functionalize PEEK-based promote This study employs simple, economical, feasible method coat Ga-ion doped bioactive glass nanoparticles (Ga-MBGs) onto sulfonated PEEK surfaces, constructing multifunctional implant. The resulting bio-functionalized macrophage M2 phenotype polarization, thus fostering an anti-inflammatory microenvironment. Moreover, direct osteogenic effect Ga ions immuno-osteogenic through promoting polarization enhance differentiation potential in vitro integration vivo. A sequence vivo experiments substantiates essential intricate function this innovative implants. regulating normal immunity metabolism. Overall, application Ga-MBGs provides effective developing surface implant, capable modulating metabolism, holds significant clinical as

Language: Английский

Citations

1