International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 271, P. 132743 - 132743
Published: May 30, 2024
Language: Английский
Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11
Published: Jan. 1, 2024
Abstract A dressing patch made of radially oriented poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofibers was successfully manufactured with a modified electrospinning strategy. The as-electrospun PHBV nanofiber exhibited uniform and bead-free nanofibrous morphology innovative arrangement, which demonstrated to possess obviously improved mechanical property, increased surface hydrophilicity enhanced biological properties compared the control traditionally randomly pattern. Interestingly, it found that pattern could induce cell migration from periphery center along in rapid manner. To further improve biofunction patch, berberine (Beri, an isoquinoline alkaloid) two different concentrations were encapsulated into during electrospinning, present sustained drug release behavior for nearly one month. Importantly, addition Beri impart excellent anti-inflammatory property by significantly inhibiting secretion pro-inflammatory factors M1 macrophages, also showed additive influence on promoting proliferation human dermal fibroblasts (HDFs), as well growth E. coli, S. aureus C. albicans, Beri-free patch. In animal studies, electrospun loading high content accelerate healing process diabetic mouse full-thickness skin wound shortened time (100% closure rate after 18 days’ treatment) quality (improved collagen deposition, re-epithelialization neovascularization hair follicles). all, this study reported therapeutic strategy integrating physical cues multiple effective treatment hard-to-heal wounds.
Language: Английский
Citations
31
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12
Published: June 13, 2024
Combination therapy with oral administration of several active ingredients is a popular clinical treatment for cancer. However, the traditional method has poor convenience, less safety, and low efficiency patients. The combination pharmaceutical techniques advanced material conversion methods can provide new solutions to this issue. In research, kind hybrid film was created via coaxial electrospraying, followed by casting process. films were composed Reglan 5-fluorouracil (5-FU)-loaded cellulose acetate (CA) core-shell particles in polyvinylpyrrolidone (PVP) matrix. Microscopic observations these demonstrated solid cross section loaded particles. X-ray diffraction Fourier-transform infrared tests verified that 5-FU showed amorphous states fine compatibilities polymeric matrices, i.e., PVP CA, respectively. vitro dissolution indicated able desired asynchronous dual-drug delivery, fast release Reglan, sustained 5-FU. controlled mechanisms shown be an erosion mechanism typical Fickian diffusion protocols reported herein pioneer approach fabricating biomaterials multiple drugs, each its own behavior, synergistic cancer treatment.
Language: Английский
Citations
31
Nanoscale, Journal Year: 2024, Volume and Issue: 16(17), P. 8573 - 8582
Published: Jan. 1, 2024
Janus nanoparticles with soluble polyvinylpyrrolidone patches located on the insoluble Eudragit RL100 sides were prepared using a side-by-side electrospraying method and are demonstrated to provide biphasic release of paracetamol in turn faster action longer time periods blood drug concentration for therapy.
Language: Английский
Citations
28
Polymers, Journal Year: 2024, Volume and Issue: 16(4), P. 501 - 501
Published: Feb. 12, 2024
Superabsorbent polymers are new functional polymeric materials that can absorb and retain liquids thousands of times their masses. This paper reviews the synthesis modification methods different superabsorbent polymers, summarizes processing for forms organizes applications research progress in industrial, agricultural, biomedical industries. Synthetic like polyacrylic acid, polyacrylamide, polyacrylonitrile, polyvinyl alcohol exhibit superior water absorption properties compared to natural such as cellulose, chitosan, starch, but they also do not degrade easily. Consequently, it is often necessary modify synthetic or graft groups onto then crosslink them balance material. Compared widely used nanoparticles, on fibers gels rise, particularly notable fields drug delivery, wound dressing, tissue engineering.
Language: Английский
Citations
27
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(7), P. 1643 - 1661
Published: Jan. 1, 2024
Electrospun nanofibers with fascinating properties provide a versatile platform for postoperative tissue anti-adhesion.
Language: Английский
Citations
24
RSC Advances, Journal Year: 2024, Volume and Issue: 14(20), P. 14374 - 14391
Published: Jan. 1, 2024
Burns are a global public health problem, which brings great challenges to and the economy.
Language: Английский
Citations
22
Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 325, P. 103098 - 103098
Published: Feb. 4, 2024
Language: Английский
Citations
20
International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 8, P. 100265 - 100265
Published: June 26, 2024
Cancer remains a major global health challenge, and despite available treatments, its prognosis poor. Recently, researchers have turned their attention to intelligent nanofibers for cancer drug delivery. These exhibit remarkable capabilities in targeted controlled release. Their inherent characteristics, such as high surface area-to-volume ratio, make them attractive candidates delivery applications. Smart can release drugs response specific stimuli, including pH, temperature, magnetic fields, light. This unique feature not only reduces side effects but also enhances the overall efficiency of systems. Electrospinning, widely used method, allows precision fabrication smart nanofibers. Its advantages include efficiency, user-friendliness, ability control various manufacturing parameters. In this review, we explore latest developments producing electrospun treatment. Additionally, discuss materials these critical parameters involved electrospinning process.
Language: Английский
Citations
18
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(32)
Published: May 23, 2024
Abstract Textile‐based wearable triboelectric nanogenerators (TENGs) have emerged as viable power sources for electronics. However, it is still a daunting challenge to realize high‐performing textile‐based nanogenerator without compromising its intrinsic textile‐like properties, such stretchability, breathability, and conformability. The above addressed by fabricating record wearable, breathable stretchable based on polarization‐induced ultra‐stretchable EVA/Nylon‐11 micro/nano‐fibers (1250%) the positive layer EVA/PVDF/BA 2 CsAgBiBr 7 (1480%) negative layer. excellent breathability (1.15 Kgm −2 d −1 ) high energy‐harvesting performance (650 V, 19.5 µAcm are attributed mechanically‐socketed structure of aligned EVA microfibers with polarized nanofibers, thus providing universal framework fabricate piezoelectric fibers. Compositional engineering surface charges coupled triboelectric‐induced enabled enhanced compared other nanogenerators. Additionally, utilized self‐powered pressure sensor an ultra‐wide sensing range (0.05–500 kPa) sensitivity (2.5 VkPa even under deformations. To best knowledge, PI‐STENG stands out amongst various sensors in terms stretchability. demonstrated machine learning‐enabled intellisensor workforce safety monitoring.
Language: Английский
Citations
13
Food Biophysics, Journal Year: 2024, Volume and Issue: 19(2), P. 425 - 438
Published: March 23, 2024
Language: Английский
Citations
9