Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(12), P. 1562 - 1562
Published: Dec. 6, 2024
Background:
Postoperative
abdominal
adhesion
is
a
prevalent
complication
following
surgery,
with
the
incidence
of
reaching
up
to
90%,
which
may
precipitate
range
adverse
outcomes.
Although
fibrous
membranes
loaded
various
anti-inflammatory
or
other
drugs
have
been
proposed
for
anti-adhesion,
most
them
suffer
from
drug-induced
effects.
Methods:
In
this
study,
lecithin-based
electrospun
polylactic
acid
(PLA)
nanofibrous
membrane
(L/P-NM)
was
developed
prevention
postoperative
adhesion,
utilizing
hydration
lubrication
theory.
The
zwitterionic
lecithin
allows
nanofiber
surface
strongly
bind
water
molecules
create
interface.
Results:
As
TGA
results
show,
content
bound
in
nanofibers
increased
significantly
increase
content.
Tribological
test
show
that
L/P-NM
reached
minimum
coefficient
friction
(COF)
about
0.112.
Additionally,
possess
favorable
tensile
property
and
biocompatibility.
Rat
model
evaluation
demonstrated
possesses
significant
anti-adhesive
performance,
an
score
only
1.
Conclusions:
Therefore,
study
offers
promising
strategy
efficiently
preventing
adhesion.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
16(3)
Published: May 1, 2024
Abstract
The
shapes
of
micro‐
and
nano‐products
have
profound
influences
on
their
functional
performances,
which
has
not
received
sufficient
attention
during
the
past
several
decades.
Electrohydrodynamic
atomization
(EHDA)
techniques,
mainly
include
electrospinning
electrospraying,
are
facile
in
manipulate
products'
shapes.
In
this
review,
generated
using
EHDA
for
modifying
drug
release
profiles
reviewed.
These
linear
nanofibers,
round
micro‐/nano‐particles,
beads‐on‐a‐string
hybrids.
They
can
be
further
divided
into
different
kinds
sub‐shapes,
explored
providing
desired
pulsatile
release,
sustained
biphasic
delayed
pH‐sensitive
release.
Additionally,
resulted
from
organizations
electrospun
nanofibers
discussed
delivery,
inner
structures
considered
together
developing
novel
delivery
systems.
future,
related
shape–performance
relationships
at
nanoscale,
besides
size,
structure
structure–performance
relationships,
would
play
important
roles
promoting
developments
field.
This
article
is
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(7), P. 789 - 789
Published: July 3, 2024
Alginate
is
a
natural
polymer
with
good
biocompatible
properties
and
potential
polymeric
material
for
the
sustainable
development
replacement
of
petroleum
derivatives.
However,
non-spinnability
pure
alginate
solutions
has
hindered
expansion
applications.
With
continuous
electrospinning
technology,
synthetic
polymers,
such
as
PEO
PVA,
are
used
co-spinning
agents
to
increase
spinnability
alginate.
Moreover,
coaxial,
parallel
Janus,
tertiary
other
diverse
novel
electrospun
fiber
structures
prepared
by
multi-fluid
have
found
new
breakthrough
problem
poor
spinning
polymers.
Meanwhile,
effectively
achieve
multiple
release
modes
drugs.
The
powerful
combination
electrostatic
widely
in
many
biomedical
fields,
tissue
engineering,
regenerative
bioscaffolds,
drug
delivery,
research
fever
continues
climb.
This
particularly
true
controlled
delivery
aspect
review
provides
brief
overview
alginate,
introduces
advances
spinning,
highlights
progress
alginate-based
nanofibers
achieving
various
modes,
pulsed
release,
sustained
biphasic
responsive
targeted
release.
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(7), P. 646 - 646
Published: April 8, 2024
Dressings
with
multiple
functional
performances
(such
as
hemostasis,
promoting
regeneration,
analgesia,
and
anti-inflammatory
effects)
are
highly
desired
in
orthopedic
surgery.
Herein,
several
new
kinds
of
medicated
nanofibers
loaded
active
ingredients
for
providing
functions
were
prepared
using
the
modified
coaxial
electrospinning
processes.
With
an
electrospinnable
solution
composed
polycaprolactone
fenoprofen
core
working
fluid,
different
types
unspinnable
fluids
(including
pure
solvent,
nanosuspension
containing
tranexamic
acid
hydroxyapatite,
dilute
polymeric
comprising
acid,
polyvinylpyrrolidone)
explored
to
implement
processes
creating
multifunctional
nanofibers.
Their
morphologies
inner
structures
assessed
through
scanning
transmission
electron
microscopes,
which
all
showed
a
linear
format
without
discerned
beads
or
spindles
diameter
smaller
than
1.0
μm,
some
them
had
incomplete
core–shell
nanostructures,
represented
by
symbol
@.
Additionally,
strange
details
about
sheaths’
topographies
observed,
included
cracks,
adhesions,
embedded
nanoparticles.
XRD
FTIR
verified
that
drugs
presented
amorphous
state,
resulted
from
fine
compatibility
among
involved
components.
All
samples
demonstrated
have
hydrophilic
property
exhibited
lower
water
contact
angle
40°
300
ms.
In
vitro
dissolution
tests
indicated
was
released
sustained
manner
over
6
h
typical
Fickian
diffusion
mechanism.
Hemostatic
intentional
distribution
on
shell
sections
able
endow
rapid
hemostatic
effect
within
60
s.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: June 13, 2024
Combination
therapy
with
oral
administration
of
several
active
ingredients
is
a
popular
clinical
treatment
for
cancer.
However,
the
traditional
method
has
poor
convenience,
less
safety,
and
low
efficiency
patients.
The
combination
pharmaceutical
techniques
advanced
material
conversion
methods
can
provide
new
solutions
to
this
issue.
In
research,
kind
hybrid
film
was
created
via
coaxial
electrospraying,
followed
by
casting
process.
films
were
composed
Reglan
5-fluorouracil
(5-FU)-loaded
cellulose
acetate
(CA)
core-shell
particles
in
polyvinylpyrrolidone
(PVP)
matrix.
Microscopic
observations
these
demonstrated
solid
cross
section
loaded
particles.
X-ray
diffraction
Fourier-transform
infrared
tests
verified
that
5-FU
showed
amorphous
states
fine
compatibilities
polymeric
matrices,
i.e.,
PVP
CA,
respectively.
vitro
dissolution
indicated
able
desired
asynchronous
dual-drug
delivery,
fast
release
Reglan,
sustained
5-FU.
controlled
mechanisms
shown
be
an
erosion
mechanism
typical
Fickian
diffusion
protocols
reported
herein
pioneer
approach
fabricating
biomaterials
multiple
drugs,
each
its
own
behavior,
synergistic
cancer
treatment.
Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(17), P. 8573 - 8582
Published: Jan. 1, 2024
Janus
nanoparticles
with
soluble
polyvinylpyrrolidone
patches
located
on
the
insoluble
Eudragit
RL100
sides
were
prepared
using
a
side-by-side
electrospraying
method
and
are
demonstrated
to
provide
biphasic
release
of
paracetamol
in
turn
faster
action
longer
time
periods
blood
drug
concentration
for
therapy.
ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(7), P. 4114 - 4144
Published: June 3, 2024
Nanofiber
scaffolds
have
gained
significant
attention
in
the
field
of
bone
tissue
engineering.
Electrospinning,
a
straightforward
and
efficient
technique
for
producing
nanofibers,
has
been
extensively
researched.
When
used
engineering
scaffolds,
electrospun
nanofibers
with
suitable
surface
properties
promote
new
growth
enhance
cell
adhesion.
Recent
advancements
electrospinning
technology
provided
innovative
approaches
scaffold
fabrication
This
review
comprehensively
examines
utilization
evaluates
relevant
literature.
The
begins
by
presenting
fundamental
principles
methodologies
electrospinning.
It
then
discusses
various
materials
production
nanofiber
engineering,
including
natural
synthetic
polymers,
as
well
certain
inorganic
materials.
challenges
associated
these
are
also
described.
focuses
on
novel
techniques
construction
such
multilayer
multifluid
electrospinning,
integration
other
methods.
enabled
precisely
aligned
nanoscale
architectures.
These
methods
facilitate
biomimetic
structures,
wherein
bioactive
substances
can
be
incorporated
released
controlled
manner
drug
delivery
purposes.
Moreover,
they
address
issues
encountered
traditional
mechanical
characteristics
biocompatibility.
Consequently,
development
implementation
technologies
revolutionized
