Facile fabrication of chitosan/hyaluronic acid hydrogel-based wound closure material Co-loaded with gold nanoparticles and fibroblast growth factor to improve anti-microbial and healing efficiency in diabetic wound healing and nursing care DOI Creative Commons
Xin Liu,

Shengwei Peng,

Pei Yan

et al.

Regenerative Therapy, Journal Year: 2024, Volume and Issue: 26, P. 1018 - 1029

Published: June 1, 2024

Generally, diabetic wounds heal very slowly and inefficiently with an increasing risk of infections. Recent nanotechnology biomaterial advances elaborate developed multi-functional hydrogels nanoparticles offer promising solutions to accelerate wound healing for patients. This research work demonstrates use solvent diffusion method develop hydrogel nanocomposites composed chitosan (CS), hyaluronic acid (HA), gold (Au), fibroblast growth factors (FGF). The biological analysis exhibited enhanced efficiency by incorporating bioactive molecules like FGF Au nanoparticles.

Language: Английский

AI‐Guided Design of Antimicrobial Peptide Hydrogels for Precise Treatment of Drug‐resistant Bacterial Infections DOI
Zhihui Jiang,

Jianwen Feng,

Fan Wang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Abstract Traditional biomaterial development lacks systematicity and predictability, posing significant challenges in addressing the intricate engineering issues related to infections with drug‐resistant bacteria. The unprecedented ability of artificial intelligence (AI) manage complex systems offers a novel paradigm for materials development. However, no AI model currently guides antibacterial biomaterials based on an in‐depth understanding interplay between In this study, AI‐guided design platform (AMP‐hydrogel‐Designer) is developed generate biomaterials. This utilizes generative multi‐objective constrained optimization thiol‐containing high‐efficiency antimicrobial peptide (AMP), that functionally coupled hydrogel form network structure. Additionally, Cu‐modified barium titanate (Cu‐BTO) incorporated facilitate further cross–linking via Cu 2+ /SH coordination produce AI‐AMP‐hydrogel. vitro, AI‐AMP‐hydrogel exhibits > 99.99% bactericidal efficacy against Methicillin‐resistant Staphylococcus aureus (MRSA) Escherichia coli ( E. coli) . Furthermore, Cu‐BTO converts mechanical stimulation into electrical signals, thereby promoting expression growth factors angiogenesis. rat dynamic wounds, AI‐AMP significantly reduces MRSA load markedly accelerates wound healing. Therefore, strategy innovative solution precisely treat bacterial infections.

Language: Английский

Citations

0
Nature-Inspired Healing: Biomimetic Nanomaterials for Advanced Wound Management DOI

Elnaz Sarrami-Foroushani,

Maryam Yavari, Atefeh Zarepour

et al.

Materials Today Sustainability, Journal Year: 2024, Volume and Issue: 28, P. 100975 - 100975

Published: Sept. 6, 2024

Language: Английский

Citations

3
Bioadhesive supramolecular polymer/hyaluronic acid hydrogel with zinc ion and dexamethasone slow release for diabetic wound healing DOI
Fang Yang,

Daoqiang Lu,

Yiqing Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137752 - 137752

Published: Nov. 1, 2024

Language: Английский

Citations

2
Facile fabrication of chitosan/hyaluronic acid hydrogel-based wound closure material Co-loaded with gold nanoparticles and fibroblast growth factor to improve anti-microbial and healing efficiency in diabetic wound healing and nursing care DOI Creative Commons
Xin Liu,

Shengwei Peng,

Pei Yan

et al.

Regenerative Therapy, Journal Year: 2024, Volume and Issue: 26, P. 1018 - 1029

Published: June 1, 2024

Generally, diabetic wounds heal very slowly and inefficiently with an increasing risk of infections. Recent nanotechnology biomaterial advances elaborate developed multi-functional hydrogels nanoparticles offer promising solutions to accelerate wound healing for patients. This research work demonstrates use solvent diffusion method develop hydrogel nanocomposites composed chitosan (CS), hyaluronic acid (HA), gold (Au), fibroblast growth factors (FGF). The biological analysis exhibited enhanced efficiency by incorporating bioactive molecules like FGF Au nanoparticles.

Language: Английский

Citations

0