Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
21(2), P. 279 - 307
Published: Feb. 1, 2024
Introduction
Photodynamic
therapy
(PDT)
has
gained
significant
attention
due
to
its
superiority
over
conventional
treatments.
In
the
context
of
skin
cancers
and
nonmalignant
diseases,
topical
application
photosensitizer
formulations
onto
affected
skin,
followed
by
illumination,
offers
distinct
advantages.
Topical
PDT
simplifies
providing
easy
access
increasing
drug
concentration
within
target
area,
confining
residual
photosensitivity
treated
skin.
However,
effectiveness
is
often
hindered
challenges
such
as
limited
penetration
or
instability.
Additionally,
hypoxic
tumor
environment
poses
further
limitations.
Nanocarriers
present
a
promising
solution
address
these
challenges.
Biomaterials Research,
Journal Year:
2022,
Volume and Issue:
26(1)
Published: Sept. 30, 2022
Near-infrared-II
(NIR-II,
1000-1700
nm)
light-triggered
photothermal
therapy
(PTT)
has
been
regarded
as
a
promising
candidate
for
cancer
treatment,
but
PTT
alone
often
fails
to
achieve
satisfactory
curative
outcomes.
Hollow
nanoplatforms
prove
be
attractive
in
the
biomedical
field
owing
merits
including
good
biocompatibility,
intrinsic
physical-chemical
nature
and
unique
hollow
structures,
etc.
On
one
hand,
themselves
can
NIR-II
agents
(PTAs),
cavities
of
which
are
able
carry
diverse
therapeutic
units
realize
multi-modal
therapies.
other
PTAs
capable
decorating
on
surface
combine
with
functions
components
encapsulated
inside
synergistic
treatment.
Notably,
generally
serve
photoacoustic
imaging
(PAI)
contrast
(CAs),
means
such
kind
also
expected
multifunctional
all-in-one
nanotheranostics.
In
this
review,
recent
advances
single-modal
PTT,
dual-modal
PTT/photodynamic
(PDT),
PTT/chemotherapy,
PTT/catalytic
PTT/gas
well
PTT/chemodynamic
(CDT)/chemotherapy,
PTT/chemo/gene
PTT/PDT/CDT/starvation
(ST)/immunotherapy
summarized
first
time.
Before
these,
typical
synthetic
strategies
structures
presented,
lastly,
potential
challenges
perspectives
related
these
novel
paradigms
future
research
clinical
translation
discussed.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(13)
Published: Feb. 27, 2023
With
the
threat
posed
by
drug-resistant
pathogenic
bacteria,
developing
non-antibiotic
strategies
for
eradicating
clinically
prevalent
superbugs
remains
challenging.
Ferroptosis
is
a
newly
discovered
form
of
regulated
cell
death
that
can
overcome
drug
resistance.
Emerging
evidence
shows
potential
triggering
ferroptosis-like
antibacterial
therapy,
but
direct
delivery
iron
species
inefficient
and
may
cause
detrimental
effects.
Herein,
an
effective
strategy
to
induce
bacterial
nonferrous
coordinating
single-atom
metal
sites
(e.g.,
Ir
Ru)
into
sp
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(19), P. 12261 - 12275
Published: April 29, 2024
Cancer
immunotherapy
holds
significant
promise
for
addressing
diverse
malignancies.
Nevertheless,
its
efficacy
remains
constrained
by
the
intricate
tumor
immunosuppressive
microenvironment.
Herein,
a
light-triggered
nanozyme
Fe-TCPP-R848-PEG
(Fe-MOF-RP)
was
designed
remodeling
The
Fe-TCPP-MOFs
were
utilized
not
only
as
core
catalysis
component
against
destruction
but
also
biocompatible
delivery
vector
of
an
immunologic
agonist,
improving
long
circulation
and
enrichment.
Concurrently,
it
catalyzes
decomposition
H2O2
within
tumor,
yielding
oxygen
to
augment
photodynamic
therapy.
induced
ferroptosis,
in
synergy
with
therapy,
prompts
liberation
tumor-associated
antigens
from
cells
inducing
immunogenic
cell
death.
Phototriggered
on-demand
release
R848
agonists
stimulated
maturation
dendritic
reverted
tumor-promoting
M2
phenotypes
into
adoptive
M1
macrophages,
which
further
reshaped
Notably,
effectively
restrains
well-established
tumors,
such
B16F10
melanoma.
Moreover,
demonstrates
distal
tumor-inhibiting
effect
upon
situ
light
treatment.
What
is
more,
lung
metastasis
model,
elicits
robust
immune
memory,
conferring
enduring
protection
rechallenge.
Our
study
presents
straightforward
broadly
applicable
strategy
crafting
nanozymes
potential
thwart
cancer
recurrence
metastasis.
Exploration,
Journal Year:
2024,
Volume and Issue:
4(6)
Published: March 24, 2024
Abstract
Photothermal
therapy
(PTT)
has
garnered
significant
attention
in
recent
years,
but
the
standalone
application
of
PTT
still
faces
limitations
that
hinder
its
ability
to
achieve
optimal
therapeutic
outcomes.
Nitric
oxide
(NO),
being
one
most
extensively
studied
gaseous
molecules,
presents
itself
as
a
promising
complementary
candidate
for
PTT.
In
response,
various
nanosystems
have
been
developed
enable
simultaneous
utilization
and
NO‐mediated
gas
(GT),
with
integration
photothermal
agents
(PTAs)
thermally‐sensitive
NO
donors
prevailing
approach.
This
combination
seeks
leverage
synergistic
effects
GT
while
mitigating
potential
risks
associated
toxicity
through
use
single
laser
irradiation.
Furthermore,
additional
internal
or
external
stimuli
employed
trigger
release
when
combined
different
types
PTAs,
thereby
further
enhancing
efficacy.
comprehensive
review
aims
summarize
advancements
gas‐assisted
cancer
treatment.
It
commences
by
providing
an
overview
precursors,
including
those
sensitive
photothermal,
light,
ultrasound,
reactive
oxygen
species,
glutathione.
These
precursors
are
discussed
context
dual‐modal
PTT/GT.
Subsequently,
incorporation
other
treatment
modalities
such
chemotherapy
(CHT),
photodynamic
(PDT),
alkyl
radical
therapy,
radiation
immunotherapy
(IT)
creation
triple‐modal
nanoplatforms
is
presented.
The
explores
tetra‐modal
therapies,
PTT/GT/CHT/PDT,
PTT/GT/CHT/chemodynamic
(CDT),
PTT/GT/PDT/IT,
PTT/GT/starvation
(ST)/IT,
PTT/GT/Ca
2+
overload/IT,
PTT/GT/ferroptosis
(FT)/IT,
PTT/GT/CDT/IT.
Finally,
challenges
future
perspectives
concerning
these
novel
paradigms
discussed.
anticipated
serve
valuable
resource
studies
focused
on
development
innovative
photothermal/NO‐based
nanotheranostics.
