Flexible Regulation of Optical Properties Based on Structure Size‐Driven Intermolecular Interactions for Phototherapy DOI Creative Commons
Zhichao Gong, Guangbo Kang, Yu Cao

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract The precise control of optical properties in molecular systems remains a challenge for phototherapy. Herein, the strategic combination aggregation‐caused quenching (ACQ) and aggregation‐induced emission (AIE) molecule creates ACQ@AIE bimolecular with tunable properties, which are almost unattainable by single‐component materials. Through systematic investigation three systems, it is established that structure size differentials dictate their intermolecular interactions consequent behaviors. Crucially, AIE smaller promotes ACQ clustering to enhance photothermal effect, while when becomes larger, particularly approaching molecule, facilitating π–π stacking boosting photodynamic effect. These distinct assembly modes revealed through combined experimental theoretical analyses, enable regulation versus effects simply regulating ratio molecules. Building on these mechanistic insights, optimal system engineered into nanoparticles exhibit mild strong excellent tumor accumulation retention, achieving near‐complete eradication minimal treatment cycles maintaining good biosafety. This work not only elucidates fundamental size‐interaction‐property relationships but also provides generalizable strategies developing intelligent photo theranostic materials controlled interaction.

Language: Английский

Integration of Motion and Stillness: A Paradigm Shift in Constructing Nearly Planar NIR-II AIEgen with Ultrahigh Molar Absorptivity and Photothermal Effect for Multimodal Phototheranostics DOI
Shiping Yang, Qian Jia, Xinwen Ou

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

The two contradictory entities in nature often follow the principle of unity opposites, leading to optimal overall performance. Particularly, aggregation-induced emission luminogens (AIEgens) with donor–acceptor (D–A) structures exhibit tunable optical properties and versatile functionalities, offering significant potential revolutionize cancer treatment. However, trapped by low molar absorptivity (ε) owing distorted configurations, ceilings their photon-harvesting capability corresponding phototheranostic performance still fall short. Therefore, a research paradigm from twisted configuration near-planar structure featuring high ε is urgently needed for AIEgens development. Herein, introducing strategy "motion stillness" into highly planar A–D–A skeleton, we successfully developed near-infrared (NIR)-II AIEgen Y5-2BO-2BTF, which boasts an impressive 1.06 × 105 M–1 cm–1 photothermal conversion efficiency (PCE) 77.8%. modification steric hindrance on benzene ring acceptor unit aggregation-caused quenching counterpart Y5-2BO, meta-CF3-substituted naphthyl, leads reversely staggered packing various intermolecular noncovalent conformational locks Y5-2BO-2BTF ("stillness"). Furthermore, −CF3 moiety acted as flexible motion ultralow energy barrier, significantly facilitating process loose aggregates ("motion"). Accordingly, nanoparticles enabled tumor eradication pulmonary metastasis inhibition through NIR-II fluorescence-photoacoustic-photothermal imaging-navigated type I photodynamic-photothermal therapy. This work provides first evidence that conformation stacking arrangement could serve novel molecular design direction AIEgens, shedding new light constructing superior agents bioimaging

Language: Английский

Citations

4
Harnessing Nanoreactors with Coupled Optical and Molecular Modalities for Photoenzymatic Modulation of Active Species in Cancer Photo‐Immunotherapy DOI Open Access
Jing Zhu, Yuxin Jin, Yunyun Wu

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

The dynamic process in tumor ablation requires both the generation of reactive oxygen species (ROS) to elicit immunogenic cell death (ICD) and subsequent reduction ROS levels maintain stimulatory activity signaling proteins recover T cells' immune function. Inspired by regulation mechanism redox homeostasis myeloid-derived suppressor cells high-selectivity alcohols/aldehydes conversions 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) Fe(III) synergistic catalysis, photoenzymatic modulators with contradictory but functions are developed for adaptive photo-immunotherapy cancer. In particular, poly(caffeic acid) (PCA) nanospheres synthesized highly efficient oxidative polymerization CA. obtained π-conjugated structures have an extended absorbance near-infrared (NIR) region, narrow band energy (0.86 eV), low exciton binding (43.56 meV) that lead polymerization-enhanced type I photosensitization photostability. Meanwhile, abundant semiquinone radicals existing PCA bestow them superior antioxidant Under NIR irradiation, elevated superoxide radical yields (3.5-fold compared CA) heat stress robust ICD. When irradiation ceases, active downregulation infiltration lymphocytes increase 2.7-fold conventional photosensitizers. As envisaged, this work demonstrates a novel tactic remodel effective inhibition growth metastasis.

Language: Английский

Citations

0
Fighting Cancer with Photodynamic Therapy and Nanotechnologies: Current Challenges and Future Directions DOI Open Access
Laura Marinela Ailioaie, Constantin Ailioaie, Gerhard Litscher

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2969 - 2969

Published: March 25, 2025

Photodynamic therapy (PDT) is an innovative treatment that has recently been approved for clinical use and holds promise cancer patients. It offers several benefits, such as low systemic toxicity, minimal invasiveness, the ability to stimulate antitumor immune responses. For certain types of cancer, it shown positive results with few side effects. However, PDT still faces some challenges, including limited light penetration into deeper tumor tissues, uneven distribution photosensitizer (PS) can also affect healthy cells, difficulties posed by hypoxic microenvironment (TME). In conditions, PDT's effectiveness reduced due insufficient production reactive oxygen species, which limits destruction lead relapse. This review highlights recent advances in photosensitizers nanotechnologies are being developed improve PDT. focuses on multifunctional nanoplatforms nanoshuttles have preclinical studies, especially treating solid tumors. One key areas focus development PSs specifically target mitochondria treat deep-seated malignant New mitochondria-targeting nano-PSs designed better water solubility extended wavelength ranges, allowing them tumors more effectively, even challenging, environments. These advancements opening new doors treatment, when combined other therapeutic strategies. Moving forward, research should optimizing PDT, creating efficient drug delivery systems, developing smarter platforms. Ultimately, these efforts aim make a first-choice option

Language: Английский

Citations

0
Enhanced efficiency and selectivity in reactive oxygen species generation using thiazolo[5,4-d]thiazole-based supramolecular photosensitizers DOI
Guang Wang,

Tongfei Qi,

Xianjun Yin

et al.

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Language: Английский

Citations

0
Peptide-photosensitizer conjugates: From molecular design to function and antibacterial applications DOI

Guanghui Zhao,

Peng Tan,

Qi Tang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162723 - 162723

Published: April 1, 2025

Language: Английский

Citations

0
Flexible Regulation of Optical Properties Based on Structure Size‐Driven Intermolecular Interactions for Phototherapy DOI Creative Commons
Zhichao Gong, Guangbo Kang, Yu Cao

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract The precise control of optical properties in molecular systems remains a challenge for phototherapy. Herein, the strategic combination aggregation‐caused quenching (ACQ) and aggregation‐induced emission (AIE) molecule creates ACQ@AIE bimolecular with tunable properties, which are almost unattainable by single‐component materials. Through systematic investigation three systems, it is established that structure size differentials dictate their intermolecular interactions consequent behaviors. Crucially, AIE smaller promotes ACQ clustering to enhance photothermal effect, while when becomes larger, particularly approaching molecule, facilitating π–π stacking boosting photodynamic effect. These distinct assembly modes revealed through combined experimental theoretical analyses, enable regulation versus effects simply regulating ratio molecules. Building on these mechanistic insights, optimal system engineered into nanoparticles exhibit mild strong excellent tumor accumulation retention, achieving near‐complete eradication minimal treatment cycles maintaining good biosafety. This work not only elucidates fundamental size‐interaction‐property relationships but also provides generalizable strategies developing intelligent photo theranostic materials controlled interaction.

Language: Английский

Citations

0