A bioinformatics approach to the design of minimal biomimetic metal-binding peptides DOI Creative Commons
Mun Hon Cheah, Claudia Spallacci, Marco Chino

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Abstract Nature-inspired or biomimetic catalyst aims to reach the high catalytic performance and selectivity of natural enzymes while possessing chemical stability processability synthetic catalysts. A promising strategy for designing catalysts holds on mimicking structure enzyme active site. This can either entail complicated total synthesis a design peptide sequences, able self-assemble in presence metal ions, thus forming metallo-peptide complexes that mimic sites enzymes. Using bioinformatics approach, we designed minimal made up eight amino acids (H4pep) act as functional trinuclear Cu site laccase enzyme. Cu(II) binding H4pep results formation Cu2+(H4pep)2 complex with β-sheet secondary structure, reduce O2. Our study demonstrates viability potential using short peptides Teaser peptide, via bioinformatics, effectively mimics copper O₂ reduction. MAIN TEXT

Language: Английский

Overcoming challenges of protonation effects induced by high isoelectric point amino acids through a synergistic strategy towards highly stable and reversible zinc electrode-electrolyte interface DOI
Xin Xu, Fuxiang Li, Mingyan Li

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 674, P. 713 - 721

Published: June 24, 2024

Language: Английский

Citations

23
Self‐Assembled Nanocarrier Delivery Systems for Bioactive Compounds DOI
Yafei Zhang, Yuning Zhang, Rui Ding

et al.

Small, Journal Year: 2024, Volume and Issue: 20(26)

Published: Jan. 12, 2024

Abstract Although bioactive compounds (BCs) have many important functions, their applications are greatly limited due to own defects. The development of nanocarriers (NCs) technology has gradually overcome the defects BCs. NCs equally as BCs some extent. Self‐assembly (SA) methods build advantages than chemical methods, and SA significant impact on structure function NCs. However, relationship among mechanism, structure, not been given enough attention. Therefore, from perspective bottom‐up building concept SA‐structure‐function is emphasized promote SA‐based First, conditions forces for occurring introduced, then basis molecular mechanism protein, polysaccharide, lipid summarized. Then, varieties structures formed based introduced in detail. Finally, facing how be well solved by also elaborated. This review attempts describe great significance constructing artificial deliver aspects SA‐structure‐function, so wide application

Language: Английский

Citations

18
Peptide Self-Assembled Nanocarriers for Cancer Drug Delivery DOI Creative Commons
Vijay Bhooshan Kumar, Busra Ozguney, Anastasia Vlachou

et al.

The Journal of Physical Chemistry B, Journal Year: 2023, Volume and Issue: 127(9), P. 1857 - 1871

Published: Feb. 22, 2023

The design of novel cancer drug nanocarriers is critical in the framework therapeutics. Nanomaterials are gaining increased interest as delivery systems. Self-assembling peptides constitute an emerging class highly attractive nanomaterials with promising applications delivery, they can be used to facilitate release and/or stability while reducing side effects. Here, we provide a perspective on peptide self-assembled for and highlight aspects metal coordination, structure stabilization, cyclization, well minimalism. We review particular challenges nanomedicine criteria and, finally, future perspectives addressing portion via self-assembling consider that intrinsic advantages such systems, along increasing progress computational experimental approaches their study design, could possibly lead classes single or multicomponent systems incorporating materials delivery.

Language: Английский

Citations

38
Elucidation of collagen amino acid interactions with metals (B, Ni) encapsulated graphene/PEDOT material: Insight from DFT calculations and MD simulation DOI

Rawlings A. Timothy,

Hitler Louis, Eze A. Adindu

et al.

Journal of Molecular Liquids, Journal Year: 2023, Volume and Issue: 390, P. 122950 - 122950

Published: Aug. 31, 2023

Language: Английский

Citations

30
Bioinspired Amino Acid Based Materials in Bionanotechnology: From Minimalistic Building Blocks and Assembly Mechanism to Applications DOI
Yuehui Wang, Sigal Rencus‐Lazar,

Haoran Zhou

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 18(2), P. 1257 - 1288

Published: Dec. 29, 2023

Inspired by natural hierarchical self-assembly of proteins and peptides, amino acids, as the basic building units, have been shown to self-assemble form highly ordered structures through supramolecular interactions. The fabrication functional biomaterials comprised extremely simple biomolecules has gained increasing interest due advantages biocompatibility, easy functionalization, structural modularity. In particular, acid based assemblies attractive physical characteristics for various bionanotechnology applications. Herein, we propose a review paper summarize design strategies well research advances smart materials. We first briefly introduce bioinspired reductionist assembly mechanism molecular materials noncovalent interactions in condensed states, including self-assembly, metal ion mediated coordination assembly, coassembly. following part, provide an overview properties functions toward applications nanotechnology biomedicine. Finally, give remaining challenges future perspectives on with desired properties. believe that this will promote prosperous development innovative formed minimalistic blocks.

Language: Английский

Citations

27
Magnetically driven nanorobots based on peptides nanodots with tunable photoluminescence for rapid scavenging reactive α-dicarbonyl species and effective blocking of advanced glycation end products DOI
Xinyue Yuan, Meng Chen,

Huilin Liu

et al.

Food Chemistry, Journal Year: 2023, Volume and Issue: 422, P. 136252 - 136252

Published: April 27, 2023

Language: Английский

Citations

26
Aromatic short peptide architectonics: Assembly and engineering DOI
Kai Tao, Haoran Wu, Lihi Adler‐Abramovich

et al.

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 142, P. 101240 - 101240

Published: Jan. 7, 2024

Language: Английский

Citations

13
Ultrasound-assisted modification of soybean protein isolate with L-histidine: Relationship between structure and function DOI Creative Commons
Jingwen Xu,

Shizhang Yan,

Jing Xu

et al.

Ultrasonics Sonochemistry, Journal Year: 2024, Volume and Issue: 107, P. 106934 - 106934

Published: May 31, 2024

Herein, the effects of ultrasound-assisted L-histidine (L-His) on physicochemical properties and conformation soybean protein isolate (SPI) were investigated. Particle size, zeta potential, turbidity, solubility used to evaluate aggregation, relationship between structural functional changes proteins was characterized using spectral analysis, surface hydrophobicity, emulsification, antioxidant properties. After L-His treatment, SPI exhibited a smaller particle higher solubility, more homogeneous micromorphology owing decrease in alpha-helix content subsequent increases potential active sulfhydryl content. In addition, analysis showed that could form complex, which changed microenvironment amino acid residues SPI, thus improving its emulsification At concentration 0.3 % w/w, nanocomplex had size (140.03 nm), ζ-potential (–23.63 mV), stability (22.48 min).

Language: Английский

Citations

12
Dynamic Polymeric Materials via Hydrogen-bond Cross-linking: Effect of Multiple Network Topologies DOI

Yuting Ren,

Xia Dong

Progress in Polymer Science, Journal Year: 2024, Volume and Issue: unknown, P. 101890 - 101890

Published: Sept. 1, 2024

Language: Английский

Citations

10
Valorization of jujube puree using lactic acid bacteria and Acetobacter pasteurianus tri-cultured co-fermentation matrix: Insight into their nutritional, sensory, volatile and non-volatile metabolomics, and physicochemical properties. DOI Creative Commons
Isaac Duah Boateng, Isaac Duah Boateng, Yongkun Ma

et al.

LWT, Journal Year: 2025, Volume and Issue: unknown, P. 117431 - 117431

Published: Feb. 1, 2025

Language: Английский

Citations

1