Nano Today, Journal Year: 2025, Volume and Issue: 63, P. 102749 - 102749
Published: April 7, 2025
Language: Английский
Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 17, 2025
Gasdermin (GSDM)-mediated pyroptosis involves the induction of mitochondrial damage and subsequent release DNA (mtDNA), which is anticipated to activate cGAS-STING pathway, thereby augmenting antitumor immune response. However, challenges lie in effectively triggering cancer cells subsequently enhancing activation with specificity. Herein, we developed intelligent self-cascaded pyroptosis-STING initiators cobalt fluoride (CoF2) nanocatalysts for catalytic metalloimmunotherapy. CoF2 a semiconductor structure enzyme-like activity generated substantial amount reactive oxygen species (ROS) under stimulation by endogenous H2O2 exogenous ultrasound. Importantly, discovered that Co-based nanomaterials themselves induce cells. Therefore, initially acted as inducers, caspase-1/GSDMD-dependent via Co2+ ROS, leading mtDNA release. Subsequently, were further utilized STING agonists specifically capable detecting pathway. These cascade events triggered robust response, modulating immunosuppressive tumor microenvironment into an immune-supportive state, providing favorable support therapy. This innovative strategy not only significantly impeded growth primary but also elicited response augment efficacy checkpoint inhibitors preventing distant progression. Overall, this study proposed self-cascade activating amplifying pathway specificity mediated pyroptosis, representing valuable avenue future
Language: Английский
Citations
1
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 13, 2025
Chemotherapy for oral squamous cell carcinoma (OSCC) is often marred by the development of multidrug resistance and systemic adverse effects. Metal ion interference therapy (MIIT) has risen as an innovative strategy to disrupt intracellular metal equilibrium in tumor cells, potentially overcoming drug resistance. However, effectiveness cancer treatment that relies on delivering single ions site constrained. To address this, we have developed a therapeutic nanoplatform employing hollow mesoporous manganese dioxide nanoparticles (HMON) which harness chelating properties tannic acid control loading release Zn2+ Pt2+, i.e., Zn@CDDP@HMON. In acidic microenvironment, Pt2+ strategically released from can inhibit mitochondrial respiration activate NADPH oxidases (NOXs), respectively, increasing superoxide anion (O2•–) hydrogen peroxide production (H2O2). The Mn4+ consumes glutathione (GSH) generate Mn2+, reacts with H2O2 Fenton-like reaction, producing hydroxyl radicals (•OH) inducing lipid peroxidation (LPO). depletion GSH also inhibits GPX4 activity, sensitizing cells ferroptosis. Furthermore, reduced Mn2+ facilitates T1-MRI imaging, allowing real-time monitoring distribution accumulation tumors.
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
Abstract Targeted regulation of pyroptosis to modulate the immune landscape has emerged as a novel design strategy for cancer immunotherapy and anti‐inflammatory therapy. However, acts double‐edged sword, making it important optimize strategies functional materials appropriately activate effective disease treatment. This paper summarizes discusses structure, pore formation, molecular mechanisms “executor” Gasdermins, well events preceding following these processes. Subsequently, focus is on reviewing that directly regulate Gasdermin formation target those indirectly before after control activity. Finally, advantages, disadvantages, future prospects designing such are provided, aiming facilitate precise design, pharmacological investigation, clinical translation pyroptosis‐related materials.
Language: Английский
Citations
0
Nano Today, Journal Year: 2025, Volume and Issue: 63, P. 102749 - 102749
Published: April 7, 2025
Language: Английский
Citations
0