Endocrinology,
Journal Year:
2017,
Volume and Issue:
158(5), P. 1074 - 1084
Published: March 15, 2017
Most
organisms,
including
humans,
have
developed
an
intrinsic
system
of
circadian
oscillators,
allowing
the
anticipation
events
related
to
rotation
Earth
around
its
own
axis.
The
mammalian
timing
orchestrates
nearly
all
aspects
physiology
and
behavior.
Together
with
systemic
signals,
emanating
from
central
clock
that
resides
in
hypothalamus,
peripheral
oscillators
orchestrate
tissue-specific
fluctuations
gene
expression,
protein
synthesis,
posttranslational
modifications,
driving
overt
rhythms
There
is
increasing
evidence
on
essential
roles
operative
metabolically
active
organs
regulation
body
glucose
homeostasis.
Here,
we
review
some
recent
findings
molecular
cellular
makeup
implications
temporal
coordination
metabolism
health
disease.
Journal of Internal Medicine,
Journal Year:
2019,
Volume and Issue:
286(2), P. 181 - 191
Published: May 13, 2019
Abstract
The
Metabolic
Syndrome
is
a
cluster
of
cardio‐metabolic
risk
factors
and
comorbidities
conveying
high
both
cardiovascular
disease
type
2
diabetes.
It
responsible
for
huge
socio‐economic
costs
with
its
resulting
morbidity
mortality
in
most
countries.
underlying
aetiology
this
clustering
has
been
the
subject
much
debate.
More
recently,
significant
interest
focussed
on
involvement
circadian
system,
major
regulator
almost
every
aspect
human
health
metabolism.
Circadian
now
implicated
several
chronic
diseases
including
diabetes
disease.
There
increasing
evidence
connecting
disturbances
rhythm
not
only
key
components
but
also
main
sleep
disturbances,
depression,
steatohepatitis
cognitive
dysfunction.
Based
this,
we
propose
that
disruption
may
be
an
important
aetiological
factor
suggest
it
renamed
‘Circadian
Syndrome’.
With
increased
recognition
Syndrome’,
medicine,
through
timing
exercise,
light
exposure,
food
consumption,
dispensing
medications
sleep,
likely
to
play
greater
role
maintenance
individual
population
future.
European Journal of Neuroscience,
Journal Year:
2018,
Volume and Issue:
51(1), P. 531 - 550
Published: Nov. 7, 2018
The
circadian
system
regulates
physiology
and
behavior.
Acute
challenges
to
the
system,
such
as
those
experienced
when
traveling
across
time
zones,
will
eventually
result
in
re-synchronization
local
environmental
cues,
but
this
is
oftentimes
accompanied
by
adverse
short-term
consequences.
When
are
chronically,
adaptation
may
not
be
achieved,
for
example
case
of
rotating
night
shift
workers.
transient
chronic
disturbance
most
frequently
referred
"circadian
disruption",
many
other
terms
have
been
proposed
used
refer
similar
situations.
It
now
beyond
doubt
that
contributes
health
disease,
emphasizing
need
clear
terminology
describing
their
goal
review
provide
an
overview
describe
disruption
discuss
quantifications
experimental
observational
settings
with
a
focus
on
human
research,
highlight
limitations
currently
available
tools.
For
research
advance
translational
science,
clear,
operationalizable,
scalable
key,
they
enable
improved
assessment
reproducibility
results,
ideally
ranging
from
mechanistic
settings,
including
animal
large-scale
randomized
clinical
trials.
Molecular Metabolism,
Journal Year:
2016,
Volume and Issue:
5(8), P. 635 - 645
Published: July 2, 2016
A
disturbed
day-night
rhythm
is
associated
with
metabolic
perturbations
that
can
lead
to
obesity
and
type
2
diabetes
mellitus
(T2DM).
In
skeletal
muscle,
a
reduced
oxidative
capacity
also
the
development
of
T2DM.
However,
whether
in
muscle
displays
humans
has
so
far
not
been
investigated.Lean,
healthy
subjects
were
enrolled
standardized
living
protocol
regular
meals,
physical
activity
sleep
reflect
our
everyday
lifestyle.
Mitochondrial
was
examined
biopsies
taken
at
five
time
points
within
24-hour
period.Core-body
temperature
lower
during
early
night,
confirming
normal
rhythm.
Skeletal
demonstrated
robust
rhythm,
significant
effect
ADP-stimulated
respiration
(state
3
MO,
state
MOG
MOGS,
p
<
0.05).
Respiration
lowest
1
PM
highest
11
MOGS:
80.6
±
4.0
vs.
95.8
4.7
pmol/mg/s).
Interestingly,
fluctuation
mitochondrial
function
observed
whole-body
energy
expenditure,
peak
expenditure
4
AM
(p
0.001).
addition,
we
demonstrate
rhythmicity
mRNA
expression
molecular
clock
genes
human
muscle.Our
results
suggest
biological
drives
rhythms
metabolism.
It
tempting
speculate
disruption
these
contribute
deterioration
health
circadian
misalignment.
Annual Review of Pathology Mechanisms of Disease,
Journal Year:
2023,
Volume and Issue:
18(1), P. 439 - 466
Published: Jan. 24, 2023
Hepatocytes
are
the
main
workers
in
hepatic
factory,
managing
metabolism
of
nutrients
and
xenobiotics,
production
recycling
proteins,
glucose
lipid
homeostasis.
Division
labor
between
hepatocytes
is
critical
to
coordinate
complex
complementary
or
opposing
multistep
processes,
similar
distributed
tasks
at
an
assembly
line.
This
so-called
metabolic
zonation
has
both
spatial
temporal
components.
Spatial
distribution
function
different
lobular
zones
necessary
perform
sequential
processes
assign
right
environment.
Moreover,
control
align
required
feeding
fasting
cycles.
Disruption
this
spatiotemporal
organization
impairs
key
with
local
systemic
consequences.
Many
diseases,
such
as
nonalcoholic
steatohepatitis
diabetes,
associated
impaired
liver
zonation.
Recent
technological
advances
shed
new
light
on
gene
expression
networks
controlling
how
their
deregulation
may
be
involved
a
large
variety
diseases.
We
summarize
current
knowledge
about
consequences
pathobiology.
SLEEP,
Journal Year:
2015,
Volume and Issue:
38(12), P. 1849 - 1860
Published: Nov. 30, 2015
A
workshop
was
held
at
the
National
Institute
for
Diabetes
and
Digestive
Kidney
Diseases
with
a
focus
on
impact
of
sleep
circadian
disruption
energy
balance
diabetes.
The
identified
number
key
principles
research
in
this
area
specific
opportunities.
Studies
would
be
facilitated
by
active
collaboration
between
investigators
sleep/circadian
metabolism/diabetes.
There
is
need
to
translate
elegant
findings
from
basic
into
improving
metabolic
health
American
public.
also
studying
humans
move
beyond
measurements
insulin
glucose
conduct
more
in-depth
phenotyping.
assessments
rhythms
as
well
sleep-disordered
breathing
incorporated
all
ongoing
cohort
studies
related
diabetes
risk.
complement
short-term
laboratory-based
human
simulated
short
shift
work
etc.
subjects
general
population
these
disorders.
It
conceivable
that
chronic
adaptations
occur,
if
so,
mechanisms
which
they
occur
needs
understood.
Particular
areas
opportunity
are
ready
translation
address
whether
CPAP
treatment
patients
pre-diabetes
obstructive
apnea
(OSA)
prevents
or
delays
onset
temporal
restricted
feeding
has
same
obesity
rates
it
does
mice.
Proceedings of The Nutrition Society,
Journal Year:
2016,
Volume and Issue:
75(4), P. 440 - 450
Published: May 26, 2016
The
circadian
system
temporally
coordinates
daily
rhythms
in
feeding
behaviour
and
energy
metabolism.
objective
of
the
present
paper
is
to
review
mechanisms
that
underlie
regulation
lipid
metabolic
pathways.
Circadian
physiology
are
generated
by
master
clock
neurons
suprachiasmatic
nucleus
(SCN).
SCN
its
efferent
targets
hypothalamus
integrate
light
signals
entrain
behavioural
as
well
cells
located
peripheral
tissues,
including
liver,
adipose
tissue
muscle.
gene
expression
regulated
at
cellular
level
a
molecular
comprising
core
set
genes/proteins.
In
hundreds
genes
involved
biosynthesis
fatty
acid
oxidation
rhythmically
activated
repressed
proteins,
hence
providing
direct
mechanism
for
lipids.
Disruption
function
results
abnormal
phenotypes
impaired
absorption,
demonstrating
essential
normal
composition
timing
meals
influence
diurnal
pathways,
with
food
intake
during
usual
rest
phase
associated
dysregulation
Recent
studies
using
metabolomics
lipidomics
platforms
have
shown
species
circadian-regulated
human
plasma,
but
not
limited
acids,
TAG,
glycerophospholipids,
sterol
lipids
sphingolipids.
future
work,
these
profiling
approaches
can
be
used
understand
better
interaction
between
diet,
mealtimes
on
metabolism
risk
obesity
diseases.
