Factors Affecting Treatment Persistence in Japanese Patients with Psoriasis Prescribed Biologics: A Real-World Study Using an Insurance Claim Database DOI Creative Commons
Celine Miyazaki, Junya Masuda,

Phiona I-Ching Tsai

et al.

Dermatology and Therapy, Journal Year: 2024, Volume and Issue: 14(11), P. 2999 - 3015

Published: Oct. 15, 2024

Poor persistence to biologics can result in suboptimal health outcomes and increased economic burden for chronic conditions, including psoriasis (PsO). In Japan, studies evaluating factors responsible biologic treatment patients with PsO are limited. We assessed (median duration overall survival) associated a real-world setting. This retrospective analysis of insurance claims records from the Japan Medical Data Center (JMDC) database included [International Classification Diseases (ICD) code: L40.x] ≥ 18 years age who had received treatment. Treatment was analyzed using data 2016 2020 by class individual (infliximab, adalimumab, ustekinumab, guselkumab, secukinumab, ixekizumab, brodalumab) bio-naïve (who initiate first at index) bio-experienced patients. Kaplan–Meier survival (treatment persistence), multivariate Cox proportional hazard regression (predictive factors) analyses were used. Overall, 1528 (mean 47.4 years). Infliximab longest median (33.6 months), while brodalumab shortest (9.7 months) among evaluated. Of evaluated, 1-year highest guselkumab (83%), lowest (45%). Bio-experienced showed slightly longer than (22.8 versus 18.1 months). Factors predictive sex [male; ratio (HR) 0.84, p = 0.016] specific diagnostic codes, such as L40.0 (PsO vulgaris; HR 0.69; 0.006), L40.1 (generalized pustular PsO; 0.75; 0.034), L40.9 unspecified; 0.72; 0.001). Meanwhile, Charlson Comorbidity Index score significantly adalimumab infliximab persistence, respectively. Among duration, survival. Sex codes influenced persistence. These findings could inform long-term plans clinical settings.

Language: Английский

Biodegradable and Stimuli-Responsive Nanomaterials for Targeted Drug Delivery in Autoimmune Diseases DOI Creative Commons
Nargish Parvin, Sang Woo Joo, Tapas Kumar Mandal

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 24 - 24

Published: Jan. 14, 2025

Autoimmune diseases present complex therapeutic challenges due to their chronic nature, systemic impact, and requirement for precise immunomodulation avoid adverse side effects. Recent advancements in biodegradable stimuli-responsive nanomaterials have opened new avenues targeted drug delivery systems capable of addressing these challenges. This review provides a comprehensive analysis state-of-the-art nanocarriers such as polymeric nanoparticles, liposomes, hydrogels engineered autoimmune therapies. These are designed degrade safely the body while releasing agents response specific stimuli, including pH, temperature, redox conditions, enzymatic activity. By achieving localized controlled release anti-inflammatory immunosuppressive agents, minimize toxicity enhance efficacy. We discuss underlying mechanisms nanomaterials, recent applications treating rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, design considerations essential clinical translation. Additionally, we address current challenges, biocompatibility, scalability, regulatory hurdles, well future directions integrating advanced nanotechnology with personalized medicine treatment. highlights transformative potential presenting them promising strategy advance precision improve patient outcomes disease management.

Language: Английский

Citations

2
Exosome-Based Macromolecular neurotherapeutic drug delivery approaches in overcoming the Blood-Brain barrier for treating brain disorders DOI
Krishna Yadav,

R. Vijayalakshmi,

Kantrol Kumar Sahu

et al.

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 199, P. 114298 - 114298

Published: April 18, 2024

Language: Английский

Citations

12
Berberine HCl and diacerein loaded dual delivery transferosomes: Formulation and optimization using Box-Behnken design DOI Creative Commons
Siddharth Singh, Rajendra Awasthi

ADMET & DMPK, Journal Year: 2024, Volume and Issue: unknown

Published: April 29, 2024

Introduction: Berberine is a poorly water-soluble alkaloid compound showing significant anti-inflammatory characteristics. It reduces the levels of pro-inflammatory and inflammatory cytokines, including tumour necrosis factor (TNF-????, IFN-????) interleukin (IL-23, IL-12, IL-23). Diacerein significantly splenomegaly associated with psoriasis. downregulates production TNF-α IL-12. Method: This study reported development transferosomes containing berberine HCl diacerein using film hydration method followed by optimization Box-Behnken design. Sodium deoxycholate was used as an edge activator. The impact independent variables (amount phosphatidylcholine, amount activator, sonication cycles) on dependent (particle size entrapment efficiency) examined. optimized formulation characterized for polydispersity index, vesicle size, efficiency, ζ potential, spectral analysis like Fourier transform infrared, thermal analysis, X-ray diffraction, deformability, transmission electron microscopy, antioxidant assay, in-vitro release, ex-vivo skin permeation studies. Results: had particle 110.90±2.8 nm high efficiency (89.50±1.5 91.23±1.8 diacerein). Deformability, activity were 2.44, 0.296, -13.3, 38.36 %, respectively. Optimized exhibited 82.093±0.81 % 85.02±3.81 release after 24 h dissolution study. transdermal flux 0.0224 µg cm-2 h-1 (2.24 cm coefficient) 0.0462 (4.62 coefficient), respectively, diacerein. Raman treated pig confirmed that can permeate skin. No change in condition or irritation observed BALB/c mice. Formulation stored at 4 25±2 °C / 60±5 relative humidity stable 3 months. Conclusions: Thus, results demonstrated successful efficient topical delivery effective management

Language: Английский

Citations

5
Nano revolution of DNA nanostructures redefining cancer therapeutics—A comprehensive review DOI
Krishna Yadav, S. Princely, Kantrol Kumar Sahu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 274, P. 133244 - 133244

Published: June 18, 2024

Language: Английский

Citations

5
Unlocking Exosome Therapeutics: The Critical Role of Pharmacokinetics in Clinical Applications DOI
Krishna Yadav, Kantrol Kumar Sahu,

Sucheta

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: 93, P. 102749 - 102749

Published: Jan. 23, 2025

Language: Английский

Citations

0
A new era of psoriasis treatment: Drug repurposing through the lens of nanotechnology and machine learning DOI

M Taha Tarek,

Riham I. El-Gogary, Amany O. Kamel

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125385 - 125385

Published: Feb. 1, 2025

Language: Английский

Citations

0
Nanotechnology in diabetes Management: Revolutionizing treatment and diagnostics DOI
Krishna Yadav

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: unknown, P. 126117 - 126117

Published: Sept. 1, 2024

Language: Английский

Citations

2
Enhancing hair regeneration: Recent progress in tailoring nano-structured lipid carriers through surface modification strategies DOI Creative Commons
Omar M. Atrooz, Nasim Reihani, M. R. Mozafari

et al.

ADMET & DMPK, Journal Year: 2024, Volume and Issue: 12(3), P. 431 - 462

Published: July 20, 2024

Background and purpose: Hair loss is a prevalent problem affecting millions of people worldwide, necessitating innovative efficient regrowth approaches. Nanostructured lipid carriers (NLCs) have become hopeful option for transporting bioactive substances to hair follicles because their compatibility with the body capability improve drug absorption. Review approach: Recently, surface modification techniques been used enhance regeneration by improving customization NLCs. These involve applying polymers, incorporating targeting molecules, modifying charge. Key results: The conversation focuses on how these stability, body, precise delivery within Moreover, it explains surface-modified NLCs can bioavailability growth-promoting agents like minoxidil finasteride. Furthermore, information interact given, uncovering possible uses in treating conditions. Conclusion: This review discusses potential altering customize them enhanced growth. It offers important upcoming studies

Language: Английский

Citations

1
Macromolecular Biomaterials Endowed Strategies for Synergistic Treatment of Psoriasis: Recent Advancements and Future Prospects DOI

Dilpreet Singh,

Neeraj Bainsal,

Nidhi Bisht

et al.

Journal of Macromolecular Science Part B, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 22

Published: June 3, 2024

Psoriasis is a chronic autoimmune skin disorder that affects millions of individuals worldwide, causing discomfort and significantly impacting their quality life. Recent advancements in the field biomaterials drug delivery have opened up promising avenues for treatment psoriasis. This manuscript summarizes key developments use innovative strategies to enhance management Biomaterials offer versatile platform localized sustained therapeutic agents psoriatic lesions. Biocompatible materials, such as hydrogels nanoparticles, been engineered encapsulate drugs biologics, providing controlled release kinetics maximize efficacy while minimizing systemic side effects. These biomaterial-based systems demonstrated remarkable potential targeting pathological mechanisms underlying psoriasis, including inflammation, hyperproliferation keratinocytes abnormal immune responses. In addition, recent personalized medicine allowed tailoring formulations individual patient needs, optimizing outcomes. Emerging technologies, 3D bioprinting, enable creation patient-specific models screening, promoting development precision therapies. Future prospects this include integration smart respond disease-specific cues, enabling on-demand real-time monitoring

Language: Английский

Citations

0
Exploring the Biomedical Frontiers of Plant-Derived Nanoparticles: Synthesis and Biological Reactions DOI Creative Commons
Selvaraj Barathi, Srinivasan Ramalingam, K. Gopinath

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(7), P. 923 - 923

Published: July 11, 2024

As contemporary technology advances, scientists are striving to identify new approaches managing several diseases. Compared the more popular physiochemical synthesis, plant-derived combination of metallic nanoparticles using plant secondary metabolites as a precursor has number benefits, including low expenses, energy consumption, biocompatibility, and medicinal usefulness. This study intends explore impacts synthetic materials (NPs), emphasizing benefits their broad use in next-generation treatments for cancer, diabetes, Alzheimer's, vector comprehensive analysis investigates potential remedies diseases looks at cutting-edge nanoformulation techniques aimed addressing function that accompany these organic substances. The purpose current review is determine how extracts contribute synthesis Silver (AgNPs), Gold (GtNPs), platinum (PtNPs). It provides an overview many phytocompounds functions biomedicine, antibacterial, antioxidant, anticancer, anti-inflammatory properties. Furthermore, this placed special focus on range applications, drug delivery systems, diagnostics therapy, present biomedical uses medical technology, toxicities.

Language: Английский

Citations

0