Implication of viruses in the etiology of preeclampsia DOI
Kenichiro Motomura, Hideaki Morita, Katsuhiko Naruse

et al.

American Journal of Reproductive Immunology, Journal Year: 2024, Volume and Issue: 91(4)

Published: April 1, 2024

Abstract Preeclampsia is one of the most common disorders that poses threat to both mothers and neonates a major contributor perinatal morbidity mortality worldwide. Viral infection during pregnancy not typically considered cause preeclampsia; however, syndromic nature preeclampsia etiology immunomodulatory effects viral infections suggest microbes could trigger subset preeclampsia. Notably, SARS‐CoV‐2 associated with an increased risk Herein, we review potential role in this great obstetrical syndrome. According vitro vivo experimental studies, can by introducing poor placentation, syncytiotrophoblast stress, and/or maternal systemic inflammation, which are all known play critical development Moreover, clinical investigations have suggested link between several viruses onset via multiple pathways. However, results research always consistent. Therefore, future studies should investigate causal elucidate mechanism behind relationship itself.

Language: Английский

SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis DOI Creative Commons

Agustín Conde‐Agudelo,

Roberto Romero

American Journal of Obstetrics and Gynecology, Journal Year: 2021, Volume and Issue: 226(1), P. 68 - 89.e3

Published: July 21, 2021

To examine the relationship between SARS-CoV-2 infection during pregnancy and risk for preeclampsia.

Language: Английский

Citations

249
Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens DOI Creative Commons
Rowan M. Karvas, Shafqat Ali Khan, Sonam Verma

et al.

Cell stem cell, Journal Year: 2022, Volume and Issue: 29(5), P. 810 - 825.e8

Published: May 1, 2022

Language: Английский

Citations

103
Inflammatory responses in the placenta upon SARS-CoV-2 infection late in pregnancy DOI Creative Commons
Lissenya B. Argueta, Lauretta A. Lacko, Yaron Bram

et al.

iScience, Journal Year: 2022, Volume and Issue: 25(5), P. 104223 - 104223

Published: April 11, 2022

The effect of SARS-CoV-2 infection on placental function is not well understood. Analysis placentas from women who tested positive at delivery showed genomic and subgenomic RNA in 22 out 52 placentas. Placentas two mothers with symptomatic COVID-19 whose pregnancies resulted adverse outcomes for the fetuses contained high levels viral Alpha variant RNA. was localized to trophoblasts that cover fetal chorionic villi direct contact maternal blood. intervillous spaces were infiltrated macrophages T cells. Transcriptome analysis an increased expression chemokines pathways associated inflammation. Infection cultures live spike protein-pseudotyped lentivirus syncytiotrophoblast and, rare cases, endothelial cells mediated by ACE2 Neuropilin-1. Viruses Alpha, Beta, Delta spikes infected significantly greater levels.

Language: Английский

Citations

78
Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors DOI Creative Commons
Levente Zsichla, Viktor Müller

Viruses, Journal Year: 2023, Volume and Issue: 15(1), P. 175 - 175

Published: Jan. 7, 2023

The clinical course and outcome of COVID-19 are highly variable, ranging from asymptomatic infections to severe disease death. Understanding the risk factors is relevant both in setting at epidemiological level. Here, we provide an overview host, viral environmental that have been shown or (in some cases) hypothesized be associated with outcomes. considered detail include age frailty, genetic polymorphisms, biological sex (and pregnancy), co- superinfections, non-communicable comorbidities, immunological history, microbiota, lifestyle patient; variation infecting dose; socioeconomic factors; air pollution. For each category, compile (sometimes conflicting) evidence for association factor outcomes (including strength effect) outline possible action mechanisms. We also discuss complex interactions between various factors.

Language: Английский

Citations

71
Zika virus NS1 drives tunneling nanotube formation for mitochondrial transfer and stealth transmission in trophoblasts DOI Creative Commons
Rafael Tomoya Michita, Long Tran, Steven J. Bark

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 20, 2025

Zika virus (ZIKV) is unique among orthoflaviviruses in its vertical transmission capacity humans, yet the underlying mechanisms remain incompletely understood. Here, we show that ZIKV induces tunneling nanotubes (TNTs) placental trophoblasts which facilitate transfer of viral particles, proteins, mitochondria, and RNA to neighboring uninfected cells. TNT formation driven exclusively via non-structural protein 1 (NS1). Specifically, N-terminal 1-50 amino acids membrane-bound NS1 are necessary for triggering host Trophoblasts infected with TNT-deficient ZIKVΔTNT mutant elicited a robust antiviral IFN-λ 1/2/3 response relative WT ZIKV, suggesting TNT-mediated trafficking allows cell-to-cell camouflaged from defenses. Using affinity purification-mass spectrometry cells expressing wild-type or non-TNT forming NS1, found mitochondrial proteins dominant NS1-interacting partners. We demonstrate infection expression elevated mitochondria levels siphoned TNTs healthy ZIKV-infected Together our findings identify stealth mechanism employs intercellular spread trophoblasts, evasion interferon response, hijacking augment propagation survival offers basis novel therapeutic developments targeting these interactions limit dissemination.

Language: Английский

Citations

2
Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility DOI Creative Commons
Nayara Azinheira Nobrega Cruz, Danielle Stoll, Dulce Elena Casarini

et al.

Clinical Science, Journal Year: 2021, Volume and Issue: 135(15), P. 1805 - 1824

Published: Aug. 1, 2021

Abstract In times of coronavirus disease 2019 (COVID-19), the impact severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 infection on pregnancy is still unclear. The presence angiotensin-converting enzyme (ACE) 2 (ACE2), main receptor for SARS-CoV-2, in human placentas indicates that this organ can be vulnerable viral during pregnancy. However, to happen, additional molecular processes are critical allow entry cells, its replication and manifestation, particularly placenta and/or feto–maternal circulation. Beyond risk vertical transmission, COVID-19 also proposed deplete ACE2 protein biological actions placenta. It postulated such effects may impair essential placentation maternal hemodynamic adaptations pregnancy, features observed several disorders This review gathers information indicating risks protective related changes pregnancies. First, we describe mechanisms SARS-CoV-2 having as a door current evidence Further, discuss central role physiological systems renin–angiotensin system (RAS) kallikrein–kinin (KKS), both active Significant knowledge gaps identified should urgently filled better understand fate pregnancies potential associated risks. Emerging will able improve early stratification high-risk with exposure well guide management follow-up these mothers their children.

Language: Английский

Citations

59
COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy DOI Creative Commons
Deepak Kumar, Sonam Verma, Indira U. Mysorekar

et al.

Translational research, Journal Year: 2022, Volume and Issue: 251, P. 84 - 95

Published: Aug. 12, 2022

Language: Английский

Citations

49
Preeclampsia and severe acute respiratory syndrome coronavirus 2 infection: a systematic review DOI Open Access
Giovanni Tossetta, Sonia Fantone, Nicola delli Muti

et al.

Journal of Hypertension, Journal Year: 2022, Volume and Issue: 40(9), P. 1629 - 1638

Published: July 22, 2022

Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of disease 2019 (COVID-19) that has rapidly spread worldwide, causing hundreds thousand deaths. Normal placentation characterized by many processes strictly regulated during pregnancy. If impaired, it can lead to gestational disorders, such as preeclampsia a multisystem disorder occurs in 2–8% pregnancies worldwide. Methods: We performed systematic search understand potential involvement SARS-CoV-2 onset using databases, PubMed and Web Science until 31 January 2022. Results: infection not only causes damage system but also infect human placenta cells impairing pivotal necessary for normal development. The inflammatory response trigged COVID-19 very similar one found suggesting possible link between Conclusion: Some studies showed affected had higher incidence compared with SARS-CoV-2-negative ones. However, increased blood pressure does allow associate hypertension common factor both conditions. At present, no diagnostic tools are available discriminate real from preeclampsia-like patients infection. Thus, new specific assure an appropriate diagnosis these patients, especially case severe disease.

Language: Английский

Citations

46
SARS-CoV-2 can infect and propagate in human placenta explants DOI Creative Commons
Amal Fahmi, Melanie Brügger, Thomas Démoulins

et al.

Cell Reports Medicine, Journal Year: 2021, Volume and Issue: 2(12), P. 100456 - 100456

Published: Nov. 4, 2021

The ongoing SARS-CoV-2 pandemic continues to lead high morbidity and mortality. During pregnancy, severe maternal neonatal outcomes placental pathological changes have been described. We evaluate infection at the maternal-fetal interface using precision-cut slices (PCSs) of human placenta. Remarkably, exposure placenta PCSs leads a full replication cycle with infectious virus release. Moreover, susceptibility tissue relates expression levels ACE2. Viral proteins and/or viral RNA are detected in syncytiotrophoblasts, cytotrophoblasts, villous stroma, possibly Hofbauer cells. While does not cause detectable cytotoxicity or pro-inflammatory cytokine response, an upregulation one order magnitude interferon type III transcripts is measured. In conclusion, our data demonstrate capacity infect propagate constitute basis for further investigation biology interface.

Language: Английский

Citations

48
Single-cell RNA sequencing reveals immunological rewiring at the maternal-fetal interface following asymptomatic/mild SARS-CoV-2 infection DOI Creative Commons
Suhas Sureshchandra, Michael Z. Zulu, Brianna M. Doratt

et al.

Cell Reports, Journal Year: 2022, Volume and Issue: 39(11), P. 110938 - 110938

Published: May 25, 2022

While severe coronavirus 2019 (COVID-19) is associated with immune activation at the maternal-fetal interface, responses to asymptomatic/mild acute respiratory syndrome 2 (SARS-CoV-2) infection during pregnancy remain unknown. Here, we assess immunological adaptations in blood and term decidua response disease pregnant women. We report attenuated antigen presentation type I interferon (IFN) signaling pathways, loss of tissue-resident decidual macrophages, upregulated cytokine/chemokine monocyte-derived macrophages. Furthermore, describe increased frequencies activated T cells decreased abundance regulatory while cytotoxic CD4/CD8 are blood. In contrast IFN higher cells. Finally, leads a narrowing cell receptor diversity both decidua. Collectively, these observations indicate that COVID-19 results remodeling landscape potential for long-term adverse outcomes offspring.

Language: Английский

Citations

29