Human TMPRSS2 and ACE2 Genetic Variability on COVID-19 Outcomes in Patients From Brazil DOI Open Access
Felipe Pantoja Mesquita, Jean Breno Silveira da Silva, Laís Lacerda Brasil de Oliveira

et al.

Published: Oct. 25, 2023

Angiotensin-converting enzyme 2 (ACE2) and the transmembrane serine protease (TMPRSS2) are recognized as entry proteins of severe acute respiratory syndrome coronavirus (SARS-CoV-2), recently their Single Nucleotide Polymorphisms (SNP) have been studied in different populations to elucidate impact on disease. The aim this study was evaluate genetic SNP ACE2 (rs35803318) TMPRSS2 (rs2070788) genes COVID-19 patients from Northeast Brazil compared with global populations, well expression quantitative trait locus (eQTL). For (rs35803318), we found 92.6% CC, 3.4% CT, 4.0% TT genotype carriers SARS-CoV-2-positive patients. Surprisingly, only frequencies were not Hardy-Weinberg equilibrium. rs2070788, 22.3% GG, 50.7% AG, 27% AA loci (eQTLs) revealed that rs35803318 associated an altered PIR gene expression, rs2070788 eQTLs association lung tissue. No significant identified between distribution SNPs 'patient's outcome. In conclusion, our results suggest may be protective factors for including Brazilian population, since presence does affect outcome described by other studies.

Language: Английский

A comprehensive review of ACE2, ACE1, TMPRSS2 and IFITM3 gene polymorphisms and their effect on the severity of COVID-19 DOI

Parisa Sahranavard-Pirbazari,

Azin Khoshghiafeh,

Mohammad Javad Kamali

et al.

Advances in Medical Sciences, Journal Year: 2023, Volume and Issue: 68(2), P. 450 - 463

Published: Sept. 1, 2023

Language: Английский

Citations

2
Association between TMPRSS2 rs2070788 polymorphism and COVID-19 severity: a case-control study in multiple cities of Iran DOI Creative Commons
Arezoo Faridzadeh, Mahmoud Mahmoudi,

Bahman Rahimlou

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 12, 2024

Introduction Host genetic variations have been identified as potential influencers of COVID-19 infection. This study aimed to examine the association between transmembrane serine protease type 2 ( TMPRSS2 ) rs2070788 single nucleotide polymorphism (SNP) and prognosis in Iranian populations. Method case-control was performed on 756 patients 59 healthy individuals across Iran. Clinical data, blood samples, presence rs2070788: G>A SNP were determined using T-ARMS-PCR. Additionally, serum levels tumor necrosis factor α (TNF-α), C-reactive protein (CRP), interleukin-6 (IL-6), IL-1β evaluated collected samples. Results No significant found genotypes allele frequencies susceptibility or mortality from However, we observed a substantial increase IL-6 CRP associated with severity COVID-19, while no such trend for TNF-α. showed considerable rise TNF-α exclusively TT genotype compared controls. Conclusion In this conducted multiple cities Iran, mortality.

Language: Английский

Citations

0
ACE2 and TMPRSS2 genetic polymorphisms as potential predictors of COVID−19 severity and outcome in females DOI Creative Commons
Sanja Matić, Dragan Milovanović, Željko Mijailović

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 18, 2024

ACE2 and TMPRSS2 represent the major gateways for SARS-CoV-2 cell entry. The presence of functional genetic polymorphisms that affect gene expression may risk severe form COVID-19 its fatal outcome.

Language: Английский

Citations

0
Expression of TMPRSS2 is up-regulated by bacterial flagellin, LPS, and Pam3Cys in human airway cells DOI Creative Commons

Marie Schwerdtner,

Annika Skalik,

Hannah Limburg

et al.

Life Science Alliance, Journal Year: 2023, Volume and Issue: 6(8), P. e202201813 - e202201813

Published: May 19, 2023

Many viruses require proteolytic activation of their envelope proteins for infectivity, and relevant host proteases provide promising drug targets. The transmembrane serine protease 2 (TMPRSS2) has been identified as a major activating influenza A virus (IAV) various coronaviruses (CoV). Increased TMPRSS2 expression associated with higher risk severe infection enhanced susceptibility to SARS-CoV-2. Here, we found that Legionella pneumophila stimulates the increased TMPRSS2-mRNA in Calu-3 human airway cells. We flagellin dominant structural component inducing expression. flagellin-induced increase was not observed at this magnitude other virus-activating proteases. also significantly by LPS, Pam3Cys, Streptococcus pneumoniae , although less pronounced. Multicycle replication H1N1pdm H3N2 IAV but SARS-CoV-2 SARS-CoV treatment. Our data suggest bacteria, particularly flagellated up-regulate cells and, thereby, may support upon co-infections. In addition, our indicate physiological role antimicrobial response.

Language: Английский

Citations

1
Human TMPRSS2 and ACE2 Genetic Variability on COVID-19 Outcomes in Patients From Brazil DOI Open Access
Felipe Pantoja Mesquita, Jean Breno Silveira da Silva, Laís Lacerda Brasil de Oliveira

et al.

Published: Oct. 25, 2023

Angiotensin-converting enzyme 2 (ACE2) and the transmembrane serine protease (TMPRSS2) are recognized as entry proteins of severe acute respiratory syndrome coronavirus (SARS-CoV-2), recently their Single Nucleotide Polymorphisms (SNP) have been studied in different populations to elucidate impact on disease. The aim this study was evaluate genetic SNP ACE2 (rs35803318) TMPRSS2 (rs2070788) genes COVID-19 patients from Northeast Brazil compared with global populations, well expression quantitative trait locus (eQTL). For (rs35803318), we found 92.6% CC, 3.4% CT, 4.0% TT genotype carriers SARS-CoV-2-positive patients. Surprisingly, only frequencies were not Hardy-Weinberg equilibrium. rs2070788, 22.3% GG, 50.7% AG, 27% AA loci (eQTLs) revealed that rs35803318 associated an altered PIR gene expression, rs2070788 eQTLs association lung tissue. No significant identified between distribution SNPs 'patient's outcome. In conclusion, our results suggest may be protective factors for including Brazilian population, since presence does affect outcome described by other studies.

Language: Английский

Citations

1