Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study

The Lancet Diabetes & Endocrinology, Journal Year: 2021, Volume and Issue: 9(6), P. 350 - 359

Published: April 28, 2021

Language: Английский

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Obesity in patients with COVID-19: a systematic review and meta-analysis

Metabolism, Journal Year: 2020, Volume and Issue: 113, P. 154378 - 154378

Published: Sept. 28, 2020

BackgroundObesity is common in patients with coronavirus disease 2019 (COVID-19). The effects of obesity on clinical outcomes COVID-19 warrant systematical investigation.ObjectiveThis study explores the risk severe among COVID-19.MethodsBody mass index (BMI) and degree visceral adipose tissue (VAT) accumulation were used as indicators for status. Publication databases including preprints searched up to August 10, 2020. Clinical included hospitalization, a requirement treatment an intensive care unit (ICU), invasive mechanical ventilation (IMV), mortality. Risks are presented odds ratios (OR) 95% confidence interval (95%CI) cohort studies BMI-defined obesity, standardized mean difference (SMD) 95%CI controlled VAT-defined excessive adiposity.ResultsA total 45, 650 participants from 30 3 adiposity assessing COVID-19. Univariate analyses showed significantly higher ORs BMI: 1.76 (95%: 1.21, 2.56, P = 0.003) 1.67 (95%CI: 1.26, 2.21, P<0.001) ICU admission, 2.19 1.56, 3.07, IMV requirement, 1.37 1.06, 1.75, 0.014) death, giving overall OR 1.43, 1.96; P<0.001). Multivariate revealed increased associated 2.36 1.37, 4.07, 0.002) 2.32 1.38, 3.90, 0.001) requiring 2.63 1.32, 5.25, 0.006) support, 1.49 1.20, 1.85, mortality, 2.09 1.67, 2.62; Compared non-severe patients, cases VAT SMD 0.49 hospitalization (95% CI: 0.11, 0.87; 0.011), 0.57 0.33, 0.81; admission 0.37 0.03, 0.71; 0.035) support. was 0.50 0.68; P<0.001).ConclusionsObesity increases death Further, appears be outcomes. These findings emphasize need effective actions by individuals, public governments increase awareness risks resulting how these heightened current global pandemic.

Language: Английский

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Global pandemics interconnected — obesity, impaired metabolic health and COVID-19

Nature Reviews Endocrinology, Journal Year: 2021, Volume and Issue: 17(3), P. 135 - 149

Published: Jan. 21, 2021

Obesity and impaired metabolic health are established risk factors for the non-communicable diseases (NCDs) type 2 diabetes mellitus, cardiovascular disease, neurodegenerative diseases, cancer nonalcoholic fatty liver otherwise known as associated disease (MAFLD). With worldwide spread of severe acute respiratory syndrome coronavirus (SARS-CoV-2), obesity also emerged important determinants 2019 (COVID-19). Furthermore, novel findings indicate that specifically visceral characteristics such hyperglycaemia, hypertension subclinical inflammation with a high COVID-19. In this Review, we highlight how increase complications mortality in We summarize consequences SARS-CoV-2 infection organ function NCDs. addition, discuss data indicating COVID-19 pandemic could have serious epidemic. As both accelerators COVID-19, might adversely influence efficacy vaccines, propose strategies prevention treatment on clinical population level, particularly while is present. This Review highlights (COVID-19) summarizes function. there discussion implications pandemic.

Language: Английский

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Central obesity, smoking habit, and hypertension are associated with lower antibody titres in response to COVID‐19 mRNA vaccine

Diabetes/Metabolism Research and Reviews, Journal Year: 2021, Volume and Issue: 38(1)

Published: May 7, 2021

Abstract Aims To explore variables associated with the serological response following COVID‐19 mRNA vaccine. Methods Eighty‐six healthcare workers adhering to vaccination campaign against were enrolled in January–February 2021. All subjects underwent two vaccine inoculations (Pfizer/BioNTech) separated by 3 weeks. Blood samples collected before 1st and 1–4 weeks after second inoculation. Clinical history, demographics, side effects recorded. Baseline anthropometric parameters measured, body composition was performed through dual‐energy‐X‐ray absorptiometry. Results Higher waist circumference lower antibody (Ab) titres ( R = −0.324, p 0.004); smokers had levels compared non‐smokers [1099 (1350) vs. 1921 (1375), 0.007], as well hypertensive versus normotensive [650 ± 1192 1911 (1364), 0.001] dyslipideamic those normal serum lipids [534 (972) vs 1872 (1406), 0.005]. Multivariate analysis showed that higher circumference, smoking, hypertension, longer time elapsed since inoculation Ab titres, independent of BMI, age. gender. Conclusions Central obesity, smoking are vaccination. Although it is currently impossible determine whether SARS‐CoV‐2 Abs lead likelihood developing COVID‐19, well‐established neutralizing antibodies correlate protection several viruses including SARS‐CoV‐2. Our findings, therefore, call for a vigilant approach, central could benefit from earlier boosters or different schedules.

Language: Английский

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Association of body mass index (BMI) with critical COVID-19 and in-hospital mortality: A dose-response meta-analysis

Metabolism, Journal Year: 2020, Volume and Issue: 117, P. 154373 - 154373

Published: Sept. 16, 2020

The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented health crisis to the entire world. As reported, body mass index (BMI) may play important role in COVID-19; however, this still remains unclear. aim of study was explore association between BMI and COVID-19 severity mortality.The Medline, PubMed, Embase Web science were systematically searched until August 2020. Random-effects models dose-response meta-analysis used synthesize results. Combined odds ratios (ORs) with their 95% confidence intervals (CIs) calculated, effect covariates analyzed using subgroup analysis meta-regression analyses.A total 16 observational studies involving 109,881 patients included meta-analysis. pooled results showed that a ≥ 30 kg/m2 had 2.35-fold risk (OR = 2.35, 95%CI 1.64-3.38, P < 0.001) for critical 2.68-fold mortality 2.68, 1.65-4.37, compared <30 kg/m2. Subgroup obesity age > 60 years associated significantly increased 3.11, 1.73-5.61, 3.93, 2.18-7.09, 0.001). Meta-regression also significant influence on (Coef. 0.036, 0.048). linear both COVID-19(Pnon-linearity 0.242) (Pnon-linearity 0.116). by 9%(OR 1.09, 1.04-1.14, 6%(OR 1.06, 1.02-1.10, 0.002) each 1 increase BMI, respectively.Evidence from suggested mortality. Further, (BMI kg/m2) in-hospital COVID-19.

Language: Английский

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Nutrition in the Actual COVID-19 Pandemic. A Narrative Review

Nutrients, Journal Year: 2021, Volume and Issue: 13(6), P. 1924 - 1924

Published: June 3, 2021

The pandemic of Coronavirus Disease 2019 (COVID-19) has shocked world health authorities generating a global crisis. present study discusses the main finding in nutrition sciences associated with COVID-19 literature. We conducted consensus critical review using primary sources, scientific articles, and secondary bibliographic indexes, databases, web pages. method was narrative literature available regarding interventions nutrition-related factors during pandemic. search engines used research were PubMed, SciELO, Google Scholar. found how lockdown promoted unhealthy dietary changes increases body weight population, showing obesity low physical activity levels as increased risk affection physiopathology. In addition, hospitalized patients presented malnutrition deficiencies vitamin C, D, B12 selenium, iron, omega-3, medium long-chain fatty acids highlighting potential effect C D interventions. Further investigations are needed to show complete role implications both prevention treatment COVID-19.

Language: Английский

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Visceral fat is associated to the severity of COVID-19

Metabolism, Journal Year: 2020, Volume and Issue: 115, P. 154440 - 154440

Published: Nov. 25, 2020

Language: Английский

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Obesity as a Risk Factor for Severe COVID-19 and Complications: A Review

Cells, Journal Year: 2021, Volume and Issue: 10(4), P. 933 - 933

Published: April 17, 2021

Emerging data suggest that obesity is a major risk factor for the progression of complications such as acute respiratory distress syndrome (ARDS), cytokine storm and coagulopathy in COVID-19. Understanding mechanisms underlying link between disease severity result SARS-CoV-2 infection crucial development new therapeutic interventions preventive measures this high-risk group. We propose multiple features contribute to prevalence severe COVID-19 complications. First, viral entry can be facilitated by upregulation receptors, like angiotensin-converting enzyme 2 (ACE2), among others. Second, obesity-induced chronic inflammation disruptions insulin leptin signaling impaired clearance disproportionate or hyper-inflammatory response, which together with elevated ferritin levels direct cause ARDS storm. Third, negative consequences on blood coagulation thrombus formation hemorrhage. In review we first summarize clinical findings relationship then further discuss potential could explain patients suffering from obesity.

Language: Английский

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Diabetes and Overweight/Obesity Are Independent, Nonadditive Risk Factors for In-Hospital Severity of COVID-19: An International, Multicenter Retrospective Meta-analysis

Diabetes Care, Journal Year: 2021, Volume and Issue: 44(6), P. 1281 - 1290

Published: April 15, 2021

OBJECTIVE Obesity is an established risk factor for severe coronavirus disease 2019 (COVID-19), but the contribution of overweight and/or diabetes remains unclear. In a multicenter, international study, we investigated if overweight, obesity, and were independently associated with COVID-19 severity whether BMI-associated was increased among those diabetes. RESEARCH DESIGN AND METHODS We retrospectively extracted data from health care records regional databases hospitalized adult patients 18 sites in 11 countries. used standardized definitions analyses to generate site-specific estimates, modeling odds each outcome (supplemental oxygen/noninvasive ventilatory support, invasive mechanical in-hospital mortality) by BMI category (reference, obese), adjusting age, sex, prespecified comorbidities. Subgroup analysis performed on preexisting Site-specific estimates combined meta-analysis. RESULTS Among 7,244 (65.6% overweight/obese), more likely require support (random effects adjusted ratio [aOR], 1.44; 95% CI 1.15–1.80) (aOR, 1.22; 1.03–1.46). There no association between mortality 0.88; 0.74–1.04). Similar observed obesity or subgroup analysis, aOR any not additionally obesity. CONCLUSIONS adults COVID-19, requiring respiratory death. diabetes, above risk.

Language: Английский

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Diabetes and COVID-19: The past, the present, and the future

Metabolism, Journal Year: 2021, Volume and Issue: 121, P. 154814 - 154814

Published: June 11, 2021

Language: Английский

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