Guideline for the Prevention and Treatment of Metabolic Dysfunction-associated Fatty Liver Disease (Version 2024)

Journal of Clinical and Translational Hepatology, Journal Year: 2024, Volume and Issue: 000(000), P. 000 - 000

Published: Nov. 4, 2024

With the rising epidemic of obesity, metabolic syndrome, and type 2 diabetes mellitus in China, dysfunction-associated non-alcoholic fatty liver disease has become most prevalent chronic disease. This condition frequently occurs Chinese patients with alcoholic hepatitis B. To address impending public health crisis its underlying issues, Society Hepatology Medical Association convened a panel clinical experts to revise update "Guideline prevention treatment (2018, China)". The new edition, titled for (Version 2024)", offers comprehensive recommendations on key including screening monitoring, diagnosis evaluation, treatment, follow-up steatotic Metabolic is now preferred English term used interchangeably Additionally, guideline emphasizes importance multidisciplinary collaboration among hepatologists other specialists manage cardiometabolic disorders effectively.

Language: Английский

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Relationship between triglyceride-glucose index baselines and trajectories with incident cardiovascular diseases in the elderly population

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Jan. 3, 2024

Abstract Background The triglyceride-glucose (TyG) index is regarded as a sophisticated surrogate biomarker for insulin resistance, offering refined means evaluating cardiovascular diseases (CVDs). However, prospective cohort studies have not simultaneously conducted baseline and multi-timepoint trajectory assessments of the TyG in relation to CVDs their subtypes elderly participants. Methods After excluding data deficiencies conditions that could influence research outcomes, this study ultimately incorporated 20,185 participants, with chronicles extending from 2016 2022. was calculated Ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Latent Class Trajectory Model (LCTM) used assess change trends over multiple time points. Utilizing Cox proportional-hazards models, we assessed relationship between quartiles various trajectories subtypes. Results During mean follow-up 4.25 years, 11,099 patients experienced new population. stratifying by quartiles, higher level associated an increased risk CVDs; aHR 95% CI highest quartile group were 1.28 (1.19–1.39). Five patterns identified LCTM model. low gradual increase reference, medium stable group, high exhibited elevated onset, 95%CIs 1.17 (1.10–1.25) 1.25 (1.15–1.35). Similar results observed CVDs. Conclusion Participants levels or developing populations.

Language: Английский

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Pump‐Less, Recirculating Organ‐on‐Chip (rOoC) Platform to Model the Metabolic Crosstalk between Islets and Liver

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(13)

Published: Jan. 15, 2024

Abstract Type 2 diabetes mellitus (T2DM), obesity, and metabolic dysfunction‐associated steatotic liver disease (MASLD) are epidemiologically correlated disorders with a worldwide growing prevalence. While the mechanisms leading to onset development of these conditions not fully understood, predictive tissue representations for studying coordinated interactions between central organs that regulate energy metabolism, particularly pancreatic islets, needed. Here, dual pump‐less recirculating organ‐on‐chip platform combines human pluripotent stem cell (sc)‐derived sc‐liver sc‐islet organoids is presented. The reproduces key aspects cross‐talk both organs, including glucose levels selected hormones, supports viability functionality while preserving reduced release pro‐inflammatory cytokines. In model disruption in response treatment high lipids fructose, exhibit hallmarks steatosis insulin resistance, sc‐islets produce cytokines on‐chip. Finally, known effects anti‐diabetic drugs Taken together, provides basis functional studies T2DM, MASLD on‐chip, as well testing potential therapeutic interventions.

Language: Английский

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Metabolic Syndrome and Metabolic Dysfunction-Associated Steatotic Liver Disease in Premenopausal Women

Mayo Clinic Proceedings, Journal Year: 2024, Volume and Issue: 99(10), P. 1615 - 1628

Published: March 28, 2024

Language: Английский

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Current Insights into the Effects of Dietary α-Linolenic Acid Focusing on Alterations of Polyunsaturated Fatty Acid Profiles in Metabolic Syndrome

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4909 - 4909

Published: April 30, 2024

The plant-derived α-linolenic acid (ALA) is an essential n-3 highly susceptible to oxidation, present in oils of flaxseeds, walnuts, canola, perilla, soy, and chia. After ingestion, it can be incorporated body lipid pools (particularly triglycerides phospholipid membranes), then endogenously metabolized through desaturation, elongation, peroxisome oxidation eicosapentaenoic (EPA) docosahexaenoic (DHA), with a very limited efficiency for DHA), beta-oxidized as energy source, or directly C18-oxilipins. At this moment, data the literature about effects ALA supplementation on metabolic syndrome (MetS) humans are inconsistent, indicating no some positive all MetS components (abdominal obesity, dyslipidemia, impaired insulin sensitivity glucoregulation, blood pressure, liver steatosis). major seem its conversion more potent EPA DHA, impact n-3/n-6 ratio, consecutive formation oxylipins endocannabinoids, inflammation, sensitivity, secretion, well adipocyte hepatocytes function. It important distinguish direct from DHA metabolites. This review summarizes most recent findings topic discusses possible mechanisms.

Language: Английский

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