Exploring the heterogeneous targets of metabolic aging at single-cell resolution

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Language: Английский

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Acute Exercise Rewires the Proteomic Landscape of Human Immune Cells

Published: Jan. 1, 2025

Language: Английский

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Using continuous glucose monitoring to prescribe an exercise time: A Randomised controlled trial in adults with type 2 diabetes

Diabetes Research and Clinical Practice, Journal Year: 2025, Volume and Issue: unknown, P. 112072 - 112072

Published: Feb. 1, 2025

Language: Английский

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Unaltered maximal power and submaximal performance correlates with an oxidative vastus lateralis proteome phenotype during tapering in male cyclists

Physiological Reports, Journal Year: 2025, Volume and Issue: 13(8)

Published: April 1, 2025

Abstract Little is known on how a short‐term reduction of training volume changes muscle proteome and physiological parameters. We investigated the impact halving during regular cyclists parameters in relation to vastus lateralis protein profiles fiber percentage ratios. Fifteen male (age: 30.1 ± 9.6 yrs.; VO 2 max: 59.4 4.4 mL∙kg −1 ∙min ; weekly volume: 8.7 2.3 h) participated an 11‐week intervention. During weeks after shared programme for 9 weeks, control group continued taper reduced by 50%. No end‐point differences were found peak power output, maximal oxygen uptake, or mean sprint test ( p > 0.05), although group, proteins involved mitochondrial aerobic respiration increased whereas those translation, catabolism, actin organization decreased, without between‐group type I/type II Tapering did not decrease at first (LT 1 ) second lactate threshold compared t0, : 216 28 W vs. 238 11 W, = 0.042, LT 290 42 318 13 0.005). Our data indicate that transient 50% reductions may be beneficial oxidative metabolism muscle.

Language: Английский

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The lipidomic and inflammatory profiles of visceral and subcutaneous adipose tissues are distinctly regulated by the SGLT2 inhibitor empagliflozin in Zucker diabetic fatty rats

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114535 - 114535

Published: March 14, 2023

The pharmacological inhibition of sodium-glucose cotransporter 2 (SGLT2) has emerged as a treatment for patients with type diabetes mellitus (T2DM), cardiovascular disease and/or other metabolic disturbances, although some the mechanisms implicated in their beneficial effects are unknown. SGLT2 inhibitor (SGLT2i) empagliflozin been suggested regulator adiposity, energy metabolism, and systemic inflammation adipose tissue. aim our study was to evaluate impact 6-week-empagliflozin on lipidome visceral (VAT) subcutaneous tissue (SAT) from diabetic obese Zucker Diabetic Fatty (ZDF) rats using an untargeted metabolomics approach. We found that increases content diglycerides oxidized fatty acids (FA) VAT, while SAT, it decreases levels several lysophospholipids phosphatidylcholines. Empagliflozin also reduces expression cytokines interleukin-1 beta (IL-1β), IL-6, tumor necrosis factor-alpha (TNFα), monocyte-chemotactic protein-1 (MCP-1) IL-10, Cd86 Cd163 M1 M2 macrophage markers no changes except decrease IL-1β. shows effect lipolysis increasing hormone-sensitive lipase (HSL) SAT VAT triglyceride (ATGL) together FA transporter cluster differentiation 36 (CD36). In conclusion, data highlighted differences lipidomes, inflammatory profiles lipolytic function, which suggest distinct metabolism these two white depots after treatment.

Language: Английский

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Effects of exercise timing on metabolic health

Obesity Reviews, Journal Year: 2023, Volume and Issue: 24(10)

Published: July 7, 2023

The increasing prevalence of metabolic syndrome is associated with major health and socioeconomic consequences. Currently, physical exercise, together dietary interventions, the mainstay treatment obesity related complications. Although exercise training includes different modalities, variable intensity, duration, volume, or frequency, which may have a distinct impact on several characteristics to syndrome, potential effects timing are yet be fully elucidated. Remarkably, promising results regard this topic been reported in last few years. Similar other time-based including nutritional therapy drug administration, time-of-day-based become useful approach for management disorders. In article, we review role discuss mechanisms that could drive metabolic-related benefits performed time-dependent manner.

Language: Английский

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Integrative proteomic analysis reveals the potential diagnostic marker and drug target for the Type‐2 diabetes mellitus

Journal of Diabetes & Metabolic Disorders, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 22, 2025

Abstract Objective The escalating prevalence of Type-2 diabetes mellitus (T2DM) poses a significant global health challenge. Utilizing integrative proteomic analysis, this study aimed to identify panel potential protein markers for T2DM, enhancing diagnostic accuracy and paving the way personalized treatment strategies. Methods Proteome profiles from two independent cohorts were integrated: cohort 1 composed 10 T2DM patients healthy controls (HC), 2 comprising 87 60 controls. Differential expression functional enrichment receiver operating characteristic (ROC) classification error matrix analysis employed. Results Comparative identified differential expressed proteins (DEPs) changes in biological pathways associated with T2DM. Further combined refined group (including CA1, S100A6, DDT), which significantly increased both cohorts. ROC revealed area under curve (AUC) values 0.94 0.87 0.97 DDT; model achieved an AUC reaching 1. Classification demonstrated could reach 0.875 60% training set 40% testing set. Conclusions This incorporates different refines high accuracy, offering more reliable clinical translation.

Language: Английский

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Multi-omics uncovers immune-modulatory molecules in plasma contributing to resistance exercise-ameliorated locomotor disability after incomplete spinal cord injury

Genome Medicine, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 5, 2025

Exercise rehabilitation therapy has garnered widespread recognition for its beneficial effects on the restoration of locomotor function in individuals with spinal cord injury (SCI). Notably, resistance exercise demonstrated significant improvements muscle strength, coordination, and overall functional recovery. However, to optimize clinical management mimic exercise-like effects, it is imperative obtain a comprehensive understanding molecular alterations that underlie these positive effects. We conducted randomized controlled trial investigating incomplete SCI. integrated analysis plasma proteomics peripheral blood mononuclear cells (PBMC) transcriptomics explore cellular changes induced by exercise. Subsequently, we established weight-loaded ladder-climbing mouse model physiological exercise, analyzed proteome metabolome, as well transcriptomes PBMC tissue. Lastly, confirm transmissibility neuroprotective intravenously injected obtained from exercised male mice into SCI female during non-acute phase. Plasma proteomic transcriptomic profiling underscored notable involvement complement pathways humoral immune response process restoring following human trial. Moreover, was emphasized interventions could effectively modulate pathways. Through employing tissues mice, our study revealed immunomodulatory responses parallel those observed trials. In addition, metabolomics an enhancement lipid metabolism exhibited ameliorating disability after via reducing demyelination inhibiting neuronal apoptosis. Our investigation elucidates associated promoting recovery demonstrate direct delivered injection, which facilitates repair. Mechanistically, multi-omics involving both reveals principal constituents responsible within are predominantly immunoregulatory factors, warranting further experimental validation. The retrospectively registered 17 July, 2024, Chinese Clinical Trial Registry (No.: ChiCTR2400087038) at https://www.chictr.org.cn/ .

Language: Английский

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Comprehensive review of the expanding roles of the carnitine pool in metabolic physiology: beyond fatty acid oxidation

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 14, 2025

Traditionally, the carnitine pool is closely related to fatty acid metabolism. However, with increasing research, pleiotropic effects of have gradually emerged. The purpose this review comprehensively investigate emerging understanding role pool, carnitine/acylcarnitines are not only auxiliaries or metabolites oxidation, but also play more complex and diverse roles, including energy metabolism, mitochondrial homeostasis, epigenetic regulation, regulation inflammation immune system, tumor biology, signal transduction, neuroprotection. This provides an overview network synthesis, transport, shuttle, potential be used as communication molecules, biomarkers therapeutic targets for multiple diseases, profound on intercellular communication, metabolic interactions between organs overall health. summarize multidimensional biological beyond its traditional in oxidation systemic mediated by carnitine/acylcarnitine provide new perspectives pharmacological research treatment innovation strategies prevention a variety diseases.

Language: Английский

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Multi-Omics Reveal Interplay between Circadian Dysfunction and Type2 Diabetes

Biology, Journal Year: 2023, Volume and Issue: 12(2), P. 301 - 301

Published: Feb. 14, 2023

Type 2 diabetes is one of the leading threats to human health in 21st century. It a metabolic disorder characterized by dysregulated glucose metabolism resulting from impaired insulin secretion or resistance. More recently, accumulated epidemiological and animal model studies have confirmed that circadian dysfunction caused shift work, late meal timing, sleep loss leads type diabetes. Circadian rhythms, 24-h endogenous biological oscillations, are fundamental feature nearly all organisms control many physiological cellular functions. In mammals, light synchronizes brain clocks feeding main stimulus peripheral tissues, such as liver, pancreas, muscles, adipose tissues. arrhythmia causes synchrony these tissues an pancreas β-cell coupled with altered secretion. addition these, gut microbes rhythms intertwined via regulation. Omics approaches play significant role unraveling how disrupted present review, we emphasize discoveries several genes, proteins, metabolites contribute emergence mellitus (T2D). The implications for comprehending clock network T2D may lead new therapeutic solutions.

Language: Английский

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