Impact of lifestyle moderate‐to‐vigorous physical activity timing on glycemic control in sedentary adults with overweight/obesity and metabolic impairments

Obesity, Journal Year: 2024, Volume and Issue: 32(8), P. 1465 - 1473

Published: June 10, 2024

Moderate-to-vigorous physical activity (MVPA) improves glucose levels; however, whether its timing affects daily glycemic control remains unclear. This study aims to investigate the impact of lifestyle MVPA on in sedentary adults with overweight/obesity and metabolic impairments.

Language: Английский

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Efficacy of morning versus afternoon aerobic exercise training on reducing metabolic syndrome components: A randomized controlled trial

The Journal of Physiology, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 28, 2023

A supervised intense aerobic exercise program improves the health of individuals with metabolic syndrome (MetS). However, it is unclear whether timing training within 24 h day would influence those benefits. The present study aimed to determine morning vs. afternoon on body composition, cardiometabolic and components MetS. One hundred thirty-nine MetS were block randomized into (AMEX; n = 42) or (PMEX; 59) groups, a non-training control group (Control; 38). Exercise was comprised 48 high-intensity interval sessions distributed over 16 weeks. Body cardiorespiratory fitness (assessed by V̇O2max${\dot V_{{{\mathrm{O}}_{\mathrm{2}}}{\mathrm{max}}}}$ ), maximal fat oxidation (FOmax blood pressure metabolites assessed before after intervention. Compared Control, both groups improved similarly composition (-0.7% loss; P 0.002), waist circumference (-2.1 cm; < 0.001), diastolic (-3.8 mmHg; 0.004) (3.5 mL kg-1 min-1 ; 0.001) no differences between groups. AMEX, in comparison PMEX, reduced systolic (-4% -1%; 0.019), plasma fasting insulin concentration (-12% -5%; resistance (-14% -4%; 0.006). Furthermore, Z score further AMEX compared PMEX (-52% -19%; 0.021) training. In summary, somewhat more efficient at reducing risk factors (i.e. sensitivity). KEY POINTS: effect time promotion an area that has gained interest recent years; however, large-scale, randomized-control studies are scarce. People (MetS) developing diseases reductions this can be precisely gauged using compound sensitive subtle evolution each component score). Supervised for weeks (morning afternoon), without dietary restriction, fitness, mean arterial non-exercise group. morning, changes dose intensity, when afternoon. Thus, improving syndrome.

Language: Английский

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Advancing Alzheimer’s Therapeutics: Exploring the Impact of Physical Exercise in Animal Models and Patients

Cells, Journal Year: 2023, Volume and Issue: 12(21), P. 2531 - 2531

Published: Oct. 27, 2023

Alzheimer’s disease (AD) is the main neurodegenerative disorder characterized by several pathophysiological features, including misfolding of tau protein and amyloid beta (Aβ) peptide, neuroinflammation, oxidative stress, synaptic dysfunction, metabolic alterations, cognitive impairment. These mechanisms collectively contribute to neurodegeneration, necessitating exploration therapeutic approaches with multiple targets. Physical exercise has emerged as a promising non-pharmacological intervention for AD, demonstrated effects on promoting neurogenesis, activating neurotrophic factors, reducing Aβ aggregates, minimizing formation neurofibrillary tangles (NFTs), dampening inflammatory processes, mitigating improving functionality neurovascular unit (NVU). Overall, neuroprotective are not singular, but multi-targets. Numerous studies have investigated physical exercise’s potential in both AD patients animal models, employing various protocols elucidate underlying neurobiological effects. The objective this review analyze neurological these models compare them conducted patients. By translating findings from different approaches, aims identify opportune, specific, personalized windows, thus advancing research use

Language: Английский

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The association between the lifestyle risk score and metabolically healthy and unhealthy obesity phenotype in Iranian women with overweight and obesity: a cross-sectional study

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 14, 2025

Background The evidence shows that all women with obesity do not develop metabolic complications thus, they may be metabolically healthy. lifestyle factors in combination influence phenotypes including healthy and unhealthy obesity. While previous studies examined associations between single phenotype, no study has risk score (LRS) phenotypes. This for the first time created LRS which is a of investigated relation to various among overweight Methods cross-sectional analyzed 278 referred health centers Tehran University Medical Sciences. A multistage sampling method was used recruit participants. based on diet, physical activity (PA), sleep, obesity, sociodemographic characteristics. binary logistic regression analysis evaluate association LRS. Results Women higher had body mass index (BMI) high-sensitivity C-reactive protein (hs-CRP) while lower high-density lipoprotein cholesterol (HDL-C), PA, education levels, sleep quality, vegetables, grains legumes intake. Furthermore, were more likely experience (MUO). Conclusion found significant an increased likelihood MUO. Further prospective are needed advance our understanding relationship

Language: Английский

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Prenatal Physical Activity, Pre-Pregnancy BMI, and Their Relationship with Gestational Diabetes: A Retrospective-Prospective Single-Center Study

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 786 - 786

Published: Feb. 24, 2025

In recent years, there has been an increase in the incidence of gestational diabetes (GDM) with serious risks for both mother and child. Pre-pregnancy BMI physical activity significantly influence GDM development. Promoting a healthy lifestyle is essential to prevent improve health outcomes baby. The aim this study was evaluate relationship between pre-pregnancy occurrence diabetes, as well assess their impact on development complications associated diabetes. A retrospective-prospective conducted from October 2024 December at tertiary referral hospital Poland. included 205 pregnant women (42 163 without diabetes) who met inclusion criteria. Data were collected using self-administered questionnaire Polish version Get Active Questionnaire Pregnancy (GAQ-P). assessed based data surveys medical records analysis. Statistical analyses Pearson's chi-square tests, logistic regression, Cramér's V coefficient determine ppBMI revealed that weight gain significant predictors, higher increasing risk contrast, before pregnancy-including its frequency, intensity, duration-was not predictor. Additionally, no associations found birth weight, mode delivery, or preterm birth. These findings highlight role while suggesting conception may have limited impact. results body mass index (BMI) emphasizing need targeted interventions aimed maintaining conception. They suggest management strategies should be important component prevention. Future research further investigate complex interaction factors metabolic refine preventive recommendations mothers newborns.

Language: Английский

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Advancing Chrononutrition for Cardiometabolic Health: A 2023 National Heart, Lung, and Blood Institute Workshop Report

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

The circadian system maintains optimal biological functions at the appropriate time of day, and disruption this organization can contribute to pathogenesis cardiometabolic disorders. timing eating is a prominent external cue that influences system. “Chrononutrition” an emerging dimension nutrition active area research examines how timing‐related aspects impact rhythms, processes, disease pathogenesis. There evidence support chrononutrition as form chronotherapy, such optimizing may serve actionable strategy improve health. This report summarizes key information from National Heart, Lung, Blood Institute's virtual workshop entitled “Chrononutrition: Elucidating Role Circadian Biology Meal Timing in Cardiometabolic Health,” which convened on May 2 3, 2023, review current literature identify critical knowledge gaps opportunities. speakers presented highlighting health earlier shorter windows more consistent day‐to‐day patterns. multidimensionality was common theme, it encompasses multiple facets along with other behaviors including sleep physical activity. Advancing field will require: (1) standardization terminology metrics; (2) scalable precise tools for real‐world settings; (3) consideration individual differences act effect modifiers; (4) deeper understanding social, behavioral, cultural influences. Ultimately, there great potential circadian‐based dietary interventions

Language: Английский

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It’s about time to exercise: development of the exercise participation explained in relation to time model

British Journal of Sports Medicine, Journal Year: 2024, Volume and Issue: 58(19), P. 1131 - 1144

Published: July 26, 2024

A perceived 'lack of time' is consistently the most commonly reported barrier to exercise. However, term fails capture multifaceted nature time-related factors. Recognising need for a more comprehensive analysis as exercise, aim this study was develop exercise participation explained in relation time (EXPERT) model. The model developed through sequential process including (1) an umbrella literature review barrier, determinant, and correlate physical activity; (2) targeted existing temporal models; (3) drafting refining it via discussions between eight authors; (4) three-round Delphi with panel members; (5) consultations seven experts potential end-users. final EXPERT includes 31 factors within four categories: needs preferences (ie, when how long does individual need/want exercise), autonomy scheduling free conditions available exercise) dimensions use exercise). Definitions, examples possible survey questions are presented each factor. provides framework understanding multi-dimensional 'time' relates participation. It moves beyond simplistic notion delves into complexity allocation context Empirical cross-cultural validations warranted.

Language: Английский

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The Potential Effect of Periodontal Disease on the Development of Metabolic Syndrome: A 10‐Year Observational Study in a Thai Adult Cohort

Journal Of Clinical Periodontology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

ABSTRACT Aim As data are sparse on the long‐term association between periodontal diseases and development of metabolic syndrome (MetS), we investigated their relationship in a Thai cohort over 10‐year observational period. Methods Medical records assessments 2161 employees Electricity Generating Authority Thailand collected at two time points, 2003 2013, were used. Experienced periodontists used standard national international criteria to define periodontitis MetS. The impact baseline subsequent MetS incidence its components was evaluated using regression analyses. Results severity extent significantly predicted decade, with higher individuals poorer health. A single percentage increase raised risk by 0.4% developing individual 0.2%. Independent health, age an emerged as factor impacting development. Conclusion This study highlights potential effect increased progression Hyperglycaemia hypertension most affected existence periodontitis.

Language: Английский

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Glycaemic Response to Acute Aerobic and Anaerobic Exercise Performed in the Morning or Afternoon in Healthy Subjects: A Crossover Trial

Journal of the International Society of Sports Nutrition, Journal Year: 2024, Volume and Issue: 21(1)

Published: Nov. 29, 2024

Background The regular practice of physical activity is considered a health promoter and appears to be one the main contributors prevention chronic diseases. However, potential effects exercise on depending time day at which it performed have not yet been fully elucidated.

Language: Английский

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Development and validation of a predictive model for white matter lesions in young- and middle-aged people

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 19, 2023

White matter lesion (WML) is an age-related disorder associated with stroke and cognitive impairment. This study aimed to investigate the risk factors build a predictive model of WML in young- middle-aged people.We performed second analysis data from Dryad Digital Repository. We selected those people who are <60 years old randomly divided them into training group validation group. investigated logistic regression built prediction nomogram based on multivariate analysis; finally, performance was evaluated for discrimination, accuracy, clinical utility.There were 308 723 Multivariate showed that age (OR = 1.49, 95% CI: 1.31-1.70), diastolic blood pressure 1.02, 1.00-1.03), carotid plaque score 1.31, 1.14-1.50), female gender 2.27, 1.56-3.30), metabolic syndrome 2.12, 1.22-3.70) significantly white lesions. The area under curve value (AUC) receiver operating (ROC) 0.734 0.642 calibration impact has good accuracy application value.Age, pressure, score, gender, WML, these utility.

Language: Английский

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