Type 2 diabetes mellitus and cardiometabolic outcomes in metabolic dysfunction-associated steatotic liver disease population

Diabetes Research and Clinical Practice, Journal Year: 2024, Volume and Issue: 211, P. 111652 - 111652

Published: April 2, 2024

Language: Английский

---

Cardiovascular-Liver-Metabolic Health: Recommendations in Screening, Diagnosis, and Management of Metabolic Dysfunction-Associated Steatotic Liver Disease in Cardiovascular Disease via Modified Delphi Approach

Circulation, Journal Year: 2024, Volume and Issue: 151(1), P. 98 - 119

Published: Dec. 26, 2024

There is a new awareness of the widespread nature metabolic dysfunction–associated steatotic liver disease (MASLD) and its connection to cardiovascular (CVD). This has catalyzed collaboration between cardiologists, hepatologists, endocrinologists, wider multidisciplinary team address need for earlier identification those with MASLD who are at increased risk CVD. The overlap in pathophysiologic processes parallel prevalence CVD, syndrome, highlight multisystem consequences poor cardiovascular–liver–metabolic health. Metabolic dysfunction associated insulin resistance, together predilection ectopic fat deposition surrounding tissues, elevated endothelial dysfunction, systemic inflammatory response, epicardium. complex pathophysiology can accelerate atherogenic dyslipidemia, atherogenesis, diastolic valvular calcification, cardiac arrhythmias. Despite mounting evidence mechanistic pathways underpinning current recommendations have not clearly focused upon as factor or target intervention We brought diverse range international experts committed promoting health related outcomes across globe. overarching goal this document offer construct clinicians field regards (1) diagnosis screening through use noninvasive serum imaging tests; (2) CVD all individuals regardless established atherosclerotic factors; (3) approach management respect prevention lifestyle, well pharmacologic surgical strategies. To achieve this, modified Delphi method was applied series evidence-based quality standard been identified.

Language: Английский

---

Metabolic Syndrome and Metabolic Dysfunction-Associated Steatotic Liver Disease in Premenopausal Women

Mayo Clinic Proceedings, Journal Year: 2024, Volume and Issue: 99(10), P. 1615 - 1628

Published: March 28, 2024

Language: Английский

---

Increased MASH-associated liver cancer in younger demographics

Hepatology Communications, Journal Year: 2025, Volume and Issue: 9(1)

Published: Jan. 1, 2025

Background: The incidence of cancer and the prevalence metabolic disease dysfunction–associated steatotic liver is increasing in young adults. However, updated global data on steatohepatitis (MASH)-associated primary (PLC) adults remains scarce. Methods: This study analyzed from Global Burden Disease between 2000 2021 to assess age-standardized incidence, mortality, disability-adjusted life years rates MASH-associated PLC (15–49 y). Results: In 2021, there were 4300 cases, 3550 deaths, 179,340 Among various etiologies adults, only had increased (annual percent change: +0.26, 95% CI: 0.16%–0.35%), with Eastern Mediterranean region having largest observed increase 1.46%, 1.40%–1.51%). made up 6% (+1% 2000) incident (+2% all this age group. Over half countries exhibited an rate 2021. Conclusions: significantly increasing, signaling likely future increases among older as cohort ages. trend necessitates urgent strategies worldwide mitigate epidemics

Language: Английский

---

Exercise-induced adipokine Nrg4 alleviates MASLD by disrupting hepatic cGAS-STING signaling

Cell Reports, Journal Year: 2025, Volume and Issue: 44(2), P. 115251 - 115251

Published: Jan. 31, 2025

Language: Английский

---

The silent burden of non‐alcoholic fatty liver disease in the elderly: A global burden of disease analysis

Alimentary Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 58(10), P. 1062 - 1074

Published: Sept. 11, 2023

Non-alcoholic fatty liver disease (NAFLD) represents a significant health threat worldwide. The growing trend towards an aging population, along with alarming rise in obesity and diabetes, may have implications for the burden of NAFLD.To assess impact NAFLD on elderly.We utilised data from Global Burden Disease study between 2010 2019 to conduct comprehensive analysis prevalence, mortality, disability-adjusted life years (DALYs) associated elderly (65-89 years), stratified by region, nation, sociodemographic Index sex.Globally, there were estimated 228 million cases, 87,230 deaths 1.46 DALYs attributed elderly. Geographically, Western Pacific region had highest From 2019, was increasing prevalence rate all areas, most pronounced change observed (annual percentage (APC) +0.95%, p < 0.001). Over period, more rapid increase men (APC +0.74%, 0.001) than women +0.63%, In regions, death rates declined, exception Americas, where slight +0.25%, = 0.002 0.38%, 0.001, respectively).Over past decade, has been increasing, necessitating immediate inclusive measures tackle rising burden.

Language: Английский

---

Milestones in the journey towards addressing obesity; Past trials and triumphs, recent breakthroughs, and an exciting future in the era of emerging effective medical therapies and integration of effective medical therapies with metabolic surgery

Metabolism, Journal Year: 2023, Volume and Issue: 148, P. 155689 - 155689

Published: Sept. 7, 2023

Language: Английский

---

Trends and predictions of metabolic risk factors for acute myocardial infarction: findings from a multiethnic nationwide cohort

The Lancet Regional Health - Western Pacific, Journal Year: 2023, Volume and Issue: 37, P. 100803 - 100803

Published: May 31, 2023

Understanding the trajectories of metabolic risk factors for acute myocardial infarction (AMI) is necessary healthcare policymaking. We estimated future projections incidence diseases in a multi-ethnic population with AMI.The and mortality contributed by AMI (diabetes mellitus [T2DM], hypertension, hyperlipidemia, overweight/obesity, active/previous smokers) were projected up to year 2050, using linear Poisson regression models based on Singapore Myocardial Infarction Registry from 2007 2018. Forecast analysis was stratified age, sex ethnicity.From 2025 predicted rise 194.4% 482 1418 per 100,000 population. The largest percentage increase within be overweight/obesity (880.0% increase), followed hypertension (248.7% T2DM (215.7% hyperlipidemia (205.0% smoking (164.8% increase). number AMI-related deaths expected 294.7% individuals while decrease 11.7% 29.9% 32.7% 49.6% smokers, 2050. Compared Chinese individuals, Indian Malay bear disproportionate burden mortality.The continue rising coming decades. Overweight/obesity will emerge as fastest-growing factor leading mortality.This research supported NUHS Seed Fund (NUHSRO/2022/058/RO5+6/Seed-Mar/03) National Medical Research Council Training Fellowship (MOH-001131). SMIR national, ministry-funded registry run Diseases Office funded Ministry Health, Singapore.

Language: Английский

---

Does early time-restricted eating reduce body weight and preserve fat-free mass in adults? A systematic review and meta-analysis of randomized controlled trials

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2024, Volume and Issue: 18(2), P. 102952 - 102952

Published: Feb. 1, 2024

Language: Английский

---

Anthropometric and cardiometabolic effects of polyphenols in people with overweight and obesity: an umbrella review

Nutrition Reviews, Journal Year: 2024, Volume and Issue: 82(11), P. 1556 - 1593

Published: Jan. 12, 2024

Abstract Context Polyphenols are plant-based compounds with potential anti-inflammatory, antioxidant, and anti-obesogenic properties. However, their effects on health outcomes remain unclear. Objective To evaluate the of polyphenols anthropometric cardiometabolic markers. Data Sources Six electronic databases—namely, EMBASE, CINAHL, PubMed, Scopus, The Cochrane Library (reviews only), Web Science—were searched for relevant systematic reviews meta-analyses (SRMAs). Extraction Three reviewers performed data extraction via a data-extraction Microsoft Excel spreadsheet. Analysis An umbrella review meta-analysis existing SRMAs was conducted. Eighteen published from 2015 to 2023, representing 445 primary studies 838 unique effect sizes, were identified. Meta-analyses conducted using random-effects models general inverse variance. Polyphenol-containing foods found significantly improve weight (-0.36 kg; 95% confidence interval [CI]: −0.62, 0.77 P &lt; 0.01, I2 = 64.9%), body mass index (−0.25 kg/m2; CI: −0.34, −0.17 0.001, 82.4%), waist circumference (−0.74 cm; −1.34, −0.15 99.3%), low-density-lipoprotein cholesterol (−1.75 mg/dL; −2.56, −0.94; 98.6%), total (−1.23 −2.00, −0.46; 0.002, 94.6%), systolic blood pressure (−1.77 mmHg; −1.77, −0.93 72.4%), diastolic (−1.45 −2.09, −0.80 61.0%), fat percentage (−0.70%; −1.03, −0.36%; 52.6%), fasting glucose (−0.18 −0.35, −0.01 0.04, 62.0%), C-reactive protein (CRP; including high-sensitivity-CRP [hs-CRP]) (−0.2972 −0.52, −0.08 87.9%). No significant changes high-density-lipoprotein (−0.12 −1.44, 0.69; 0.67, 89.4%) triglycerides (−1.29 −2.74, 0.16; 0.08, 85.4%). Between-study heterogeneity could be explained by polyphenol subclass differences. Conclusion findings this support beneficial metabolic markers, but discretion is warranted determine clinical significance magnitude biomarker improvements. Systematic Review Registration International Prospective Register Reviews no. CRD42023420206.

Language: Английский

---