Increased mortality from alcohol use disorder, alcohol‐associated liver disease, and liver cancer from alcohol among older adults in the United States: 2000 to 2021 DOI Creative Commons
Pojsakorn Danpanichkul, Kwanjit Duangsonk, Elaine Tham

et al.

Alcohol Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Abstract Background To investigate the trends in alcohol‐associated liver disease (ALD), cancer from alcohol, and alcohol use disorder (AUD) burden among older adults United States (US). Methods We gathered ALD, AUD prevalence, mortality, age‐standardized rates (ASRs) Global Burden of Disease (GBD) Study 2021 between 2010 2021. estimated annual percent change (APC) with confidence intervals (CIs) for (>70 years) States. The findings were contrasted global estimates categorized by sex state. Results In 2021, there approximately 512,340 cases AUD, 56,990 4490 primary contrast to declining ASRs prevalence mortality burden, these parameters increased From 2000 (APC: 0.54%, 95% CI 0.43% 0.65%), ALD (APC + 0.22% 0.86%), 2.93%, 2.76% 3.11%) increased. Forty states exhibited a rise adults. Conclusion Our highlighted Sates, contrasting decline trends. Public health strategies on which targets adults, are urgently needed.

Language: Английский

Disparities in metabolic dysfunction-associated steatotic liver disease and cardiometabolic conditions in low and lower middle-income countries: a systematic analysis from the global burden of disease study 2019 DOI
Pojsakorn Danpanichkul,

Kanokphong Suparan,

Priyata Dutta

et al.

Metabolism, Journal Year: 2024, Volume and Issue: 158, P. 155958 - 155958

Published: June 26, 2024

Language: Английский

Citations

29
What Is New in Metabolic Dysfunction-Associated Steatotic Liver Disease in Lean Individuals: From Bench to Bedside DOI Open Access
Pojsakorn Danpanichkul, Kanokphong Suparan, Donghee Kim

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(1), P. 278 - 278

Published: Jan. 3, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) affects more than 30% of the world’s adult population. While it is associated with obesity and metabolic syndrome, emerging evidence has shown that a substantial number MASLD patients have normal body mass index (“lean individuals MASLD”). In this article, we provide an overview definition, epidemiology, pathogenesis, clinical outcomes lean updates on current management.

Language: Английский

Citations

22
Incidence of liver cancer in young adults according to the Global Burden of Disease database 2019 DOI
Pojsakorn Danpanichkul, Majd B. Aboona,

Banthoon Sukphutanan

et al.

Hepatology, Journal Year: 2024, Volume and Issue: 80(4), P. 828 - 843

Published: April 8, 2024

The worldwide burden of cancer is increasing in younger populations. However, the epidemiology primary liver remains understudied young adults compared to other forms.

Language: Английский

Citations

21
Socio‐economic association of alcohol use disorder and cardiovascular and alcohol‐associated liver disease from 2010 to 2019 DOI
Pojsakorn Danpanichkul, Vincent Chen, Nathorn Chaiyakunapruk

et al.

Alimentary Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 60(3), P. 340 - 349

Published: May 29, 2024

Summary Backgrounds and Aims Alcohol use leads to disabilities deaths worldwide. It not only harms the liver but also causes alcohol disorder (AUD) heart disease. Additionally, consumption contributes health disparities among different socio‐economic groups. Methods We estimated global regional trends in burden of AUD, disease, cardiovascular disease from using methodology Global Burden Disease study. Results In 2019, highest disability‐adjusted life years rate per 100,000 population was due AUD (207.31 [95% Uncertainty interval (UI) 163.71–261.66]), followed by alcohol‐associated (ALD) (133.31 UI 112.68–156.17]). The prevalence decreased for (APC [annual percentage change] −0.38%) alcohol‐induced cardiomyopathy −1.85%) increased ALD 0.44%) cancer 0.53%). Although mortality 0.30%), rates other diseases decreased. Between 2010 complications countries with low low‐middle sociodemographic index (SDI), contributing more significantly burden. Conclusion liver, has been high increasing over past decade, particularly complications. Lower SDI are this There is a pressing need effective strategies address escalating

Language: Английский

Citations

16
Global epidemiology of alcohol‐associated liver disease in adolescents and young adults DOI
Pojsakorn Danpanichkul, Vincent Chen,

Primrose Tothanarungroj

et al.

Alimentary Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 60(3), P. 378 - 388

Published: June 3, 2024

Summary Background and Aims The objective of the study was to analyse prevalence, incidence, death alcohol‐associated liver disease (ALD) among adolescents young adults globally, continentally, nationally, focusing on trends over time. Methods analysed data from Global Burden Disease (GBD) between 2000 2019. It examined ALD's in aged 15–29, segmented by region, nation, sociodemographic index. analysis utilised Joinpoint regression modelling calculate annual per cent change (APC) rate these parameters Results In 2019, there were 281,450 ALD prevalences, 18,930 incidences, 3190 deaths globally. From age‐adjusted prevalence 100,000 increased 25–29 age group (APC: +0.6%, p = 0.003), remained stable ages 20–24 ( 0.302) 15–19 0.160). Prevalence significantly (19‐fold increase) (2.5‐fold increase). rates all groups Africa Eastern Mediterranean region. Around three‐quarters countries territories experienced an increase incidence adults. Conclusion Over two decades, burden has emphasises importance public health policies aimed at reducing alcohol consumption preventing younger populations.

Language: Английский

Citations

16
Global and regional burden of alcohol-associated liver disease and alcohol use disorder in the elderly DOI Creative Commons
Pojsakorn Danpanichkul, Kanokphong Suparan, Cheng Han Ng

et al.

JHEP Reports, Journal Year: 2024, Volume and Issue: 6(4), P. 101020 - 101020

Published: Jan. 26, 2024

Abstract

Background & Aims

Alcohol-associated liver diseases (ALDs) and alcohol use disorder (AUD) pose a global health risk. AUD is underrecognized in the elderly, burden of complications, including ALD, may increase with aging populations rising intake. However, there lack epidemiological evidence on ALD elderly.

Methods

Using Global Burden Disease Study 2019, we analyzed prevalence, mortality, disability-adjusted life years (DALYs), age-standardized rates (ASRs), temporal change from 2000 to 2019 overall population elderly (65–89 years). The findings were categorized by sex, region, nation, sociodemographic index.

Results

prevalence higher than those adolescents young adults, whereas levels lower adults. In 9.39 million cases (8.69% population) AUD, 3.23 (21.8% alcohol-associated cirrhosis, 68,468 (51.27% cancer among ASRs increased most regions; contrary, death DALYs decreased regions. Nevertheless, many areas.

Conclusions

Our highlighted comparable that population. Public strategies targeting are urgently needed.

Impact implications

disease (ALD) increasing. Advances healthcare education have resulted remarkable spike expectancy consequential aging. little known about epidemiology study indicates increasing population, necessitating early detection, intervention, tailored care unique needs complexities faced older individuals grappling these conditions.

Language: Английский

Citations

15
Metabolic Syndrome and Metabolic Dysfunction-Associated Steatotic Liver Disease in Premenopausal Women DOI
Pojsakorn Danpanichkul, Cheng Han Ng, Mark Muthiah

et al.

Mayo Clinic Proceedings, Journal Year: 2024, Volume and Issue: 99(10), P. 1615 - 1628

Published: March 28, 2024

Language: Английский

Citations

9
Disease and Economic Burden of Plastic Surgery-Related Diseases in the United Kingdom DOI
Zhen Yu Wong,

Kai Qi Ou,

Zhen Ning Wong

et al.

Plastic and Aesthetic Nursing, Journal Year: 2025, Volume and Issue: 45(2), P. 108 - 116

Published: March 30, 2025

This study aimed to assess the burden and economic impact of disease associated with plastic reconstructive surgery in United Kingdom. We calculated a value per statistical life year £60,000 person Kingdom ($75,510 U.S. dollars). found that 2019, estimated age-standardized incident rates, death disability-adjusted years surgery-related conditions were 361.47 100,000, 19.5 100,000 551.0 respectively. Burn emerged as leading contributor overall burden, accounting for 32%, followed by decubitus ulcer (21%) breast cancer (17%). The diseases amounted £34.3 billion (43.2 dollars) exhibiting steady increase from £19.6 (24.7 1990. Plastic diseases, primarily cancer, thermal burns, malignant melanoma, impose substantial on U.K. health care system. These findings hold significant implications national policy, funding allocation, research prioritization.

Language: Английский

Citations

1
From Shadows to Spotlight: Exploring the Escalating Burden of Alcohol-Associated Liver Disease and Alcohol Use Disorder in Young Women DOI
Pojsakorn Danpanichkul, Cheng Han Ng, Mark Muthiah

et al.

The American Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 119(5), P. 893 - 909

Published: Dec. 26, 2023

INTRODUCTION: The burden of alcohol-related complications is considerable, particularly alcohol-associated liver disease and alcohol use disorder (AUD). However, there are deficiencies in comprehensive epidemiological research focusing on these issues, especially among young women who display higher susceptibility to such compared with their male counterparts. We thus aimed determine the global conditions this vulnerable group. METHODS: Leveraging data from Global Burden Disease Study 2019, we analyzed prevalence, mortality, disability-adjusted life years cirrhosis (AC), cancer alcohol, AUD women. findings were categorized by region, nation, sociodemographic index. RESULTS: highest age-standardized prevalence rates observed (895.96 [95% uncertainty interval (UI) 722.6–1,103.58]), followed AC (65.33 UI 48.37–86.49]) (0.13 0.09–0.19]) per 100,000 people. mortality (0.75 0.55–0.97]), (0.48 0.43–0.53]) (0.06 0.04–0.09]). burdens Central Europe, whereas high-income Asia Pacific had alcohol. DISCUSSION: Throughout past decade, trend varied regions while impact has increased, requiring urgent public health strategy mitigate complications, female patients Europe Asia-Pacific region.

Language: Английский

Citations

18
Mortality outcomes in individuals with MASLD versus MASLD and increased alcohol intake DOI
Majd B. Aboona, Pojsakorn Danpanichkul, Vincent Chen

et al.

Journal of Gastroenterology and Hepatology, Journal Year: 2024, Volume and Issue: 39(11), P. 2456 - 2463

Published: Aug. 22, 2024

Abstract Background and Aim Metabolic dysfunction‐associated steatotic liver disease (MASLD) has become a leading cause of chronic worldwide. A new entity termed MetALD also been described is defined as individuals with MASLD increased alcohol intake. However, the natural history compared unknown. We aimed to compare longitudinal outcomes in patients versus MetALD. Methods This study was performed using data from National Health Nutrition Examination Survey 2011 2018. (defined by United States Fatty Liver Index > 30) who met cardiometabolic criteria including body mass index (BMI) 25 (BMI 23 Asians), hypertension, diabetes mellitus, dyslipidemia, hypertriglyceridemia were included. intake (3–6 standard drinks per day males; 2–5 females). comparison overall, cardiovascular, cancer‐related, other causes mortality performed. Results total 2838 2557 included median follow‐up time 56 months. at risk cancer‐related (hazard ratio 1.32; 95% confidence interval 1.14–1.53; P < 0.01). there no significant difference mortality. Conclusions Patients higher for than MASLD. Close attention regular cancer surveillance accurate classification consumption diagnosed warranted help improve patient care outcome.

Language: Английский

Citations

8