Diverse Cytokines Secreted by Adipocyte in Linking Cardio-Metabolic Disorder and SLE DOI Creative Commons
Min Lai, Kai‐Hsin Lin, Xiaofang Chen

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(11)

Published: Oct. 31, 2024

Systemic lupus erythematosus (SLE) is a multi-factorial autoimmune-mediated disease with hyper-stimulation of immune cells especially the T lymphocytes. By this method, it might facilitate systematic damages in multiple tissues and organs. Otherwise, SLE also correlated diverse cardio-metabolic comorbidities, including dyslipidemia, insulin resistance, hypertension. It worth-noting that risk disorders significantly higher compared healthy patients which was reported as approximately one-third were proved obesity. Notably, current focus shifting to implementing protective strategies well elucidating underlying mechanisms lupus-mediated obese status. On other hand, adipocyte, most abundant endocrine cell fat tissue, are dysfunctional individuals aberrant secretion adipokines. proposing adipokine link pathology SLE, whereas related mechanism complicated. In review, functions potential by listed. Furthermore, recommendations, identify therapeutic targets for treatment summarized.

Language: Английский

Identification and analysis of key genes in adipose tissue for human obesity based on bioinformatics DOI Creative Commons
Y Y Hua,

Danyingzhu Xie,

Yugang Zhang

et al.

Gene, Journal Year: 2023, Volume and Issue: 888, P. 147755 - 147755

Published: Sept. 1, 2023

Obesity is a complex condition that affected by variety of factors, including the environment, behavior, and genetics. However, genetic mechanisms underlying obesity remains poorly elucidated. Therefore, our study aimed at identifying key genes for human using bioinformatics analysis.The microarray datasets adipose tissue in humans were downloaded from Gene Expression Omnibus (GEO) database. After selection differentially expressed (DEGs), we used Lasso regression Support Vector Machine (SVM) algorithm to further identify feature genes. Moreover, immune cell infiltration analysis, gene set variation analysis (GSVA), GeneCards database transcriptional regulation conducted potential which may impact obesity. We utilized receiver operating characteristic (ROC) curve diagnostic efficacy Finally, verified experiments animal experiments. The statistical analyses validation SPSS version 28.0, graph generated GraphPad Prism 9.0 software. R language (version 4.2.2), with significance threshold p < 0.05 used.199 DEGs selected Limma package, subsequently, 5 (EGR2, NPY1R, GREM1, BMP3 COL8A1) through SVM algorithm. Through various analyses, found some signaling pathways influence also revealed crucial role these microenvironment, as well their strong correlations obesity-related Additionally, ROC showed all had good predictive efficiency after vitro experiments, EGR2, NPY1R GREM1 identified genes.This biomarkers humans. EGR2 was discovered first time, provide novel targets diagnosing treating

Language: Английский

Citations

7
Mechanisms of colon toxicity induced by long-term perfluorooctanoic acid exposure in mice DOI Creative Commons

Xiannan Meng,

Wei Li,

Yongjing Qian

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 282, P. 116762 - 116762

Published: July 23, 2024

Language: Английский

Citations

2
Adipose failure through adipocyte overload and autoimmunity DOI Creative Commons
Nicola Susca, Patrizia Leone, Marcella Prete

et al.

Autoimmunity Reviews, Journal Year: 2023, Volume and Issue: 23(3), P. 103502 - 103502

Published: Dec. 13, 2023

Metabolic syndrome poses a great worldwide threat to the health of patients. Increased visceral adiposity is recognized as main determinant detrimental clinical effects insulin resistance. Inflammation and immune system activation in adipose tissue (AT) have central role pathophysiology metabolic syndrome, but mechanisms linking increased immunity AT remain part elusive. In this review, we support adipocyte overload relative failure key determinants triggering aggression AT. This provides mechanistic explanation wellness metabolically normal obese people disruption signaling lean people.

Language: Английский

Citations

4
Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition DOI Creative Commons
Jie Cao,

Lanqin Li,

Runge Zhang

et al.

Natural Products and Bioprospecting, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 26, 2024

Neurodegenerative diseases (NDs) are common chronic arising from progressive damage to the nervous system. Here, in-house natural product database screening revealed that libertellenone C (LC) obtained fermentation products of Arthrinium arundinis separated gut a centipede collected in our Tongji campus, showed remarkable neuroprotective effect. Further investigation was conducted clarify specific mechanism. LC dose-dependently reversed glutamate-induced decreased viability, accumulated reactive oxygen species, mitochondrial membrane potential loss, and apoptosis SH-SY5Y cells. Network pharmacology analysis predicted targets were most likely directly related oxidative stress regulation inflammatory factor-associated signaling pathways. study demonstrated attenuated nitrite, TNF-α, IL-1β production inducible nitric oxide synthase cyclooxygenase expression lipopolysaccharide-induced BV-2 could inhibit NLRP3 inflammasome activation by decreasing levels NLRP3, ASC, cleaved Caspase-1, NF-κB p65. Our results provide new understanding how inhibits microglia, providing neuroprotection. These findings might guide development effective LC-based therapeutic strategies for NDs.

Language: Английский

Citations

1
Proprotein convertase subtilisin/kexin type 9 deficiency in extrahepatic tissues: emerging considerations DOI Creative Commons

Fengyuan Lu,

En Li, Xiaoyu Yang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 30, 2024

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is primarily secreted by hepatocytes. PCSK9 critical in liver low-density lipoprotein receptors (LDLRs) metabolism. In addition to its hepatocellular presence, has also been detected cardiac, cerebral, islet, renal, adipose, and other tissues. Once perceived as a “harmful factor,” focal point for the targeted inhibition of both systemic circulation localized tissues treat diseases. However, contributes maintenance normal physiological functions numerous extrahepatic tissues, encompassing LDLR-dependent -independent pathways. Consequently, deficiency may harm close association with several pathophysiological processes, such lipid accumulation, mitochondrial impairment, insulin resistance, abnormal neural differentiation. This review encapsulates beneficial effects on processes potential disorders arising from provides comprehensive analysis disparities between experimental clinical research findings regarding associated deficiency. The aim improve current understanding diverse inhibition.

Language: Английский

Citations

1
Multi-omics landscape of childhood simple obesity: novel insights into pathogenesis and biomarkers discovery DOI Creative Commons

Yi Ren,

Peng Huang, Lu Zhang

et al.

Cell & Bioscience, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 28, 2024

The increasing incidence of childhood obesity annually has led to a surge in physical and mental health risks, making it significant global public concern. This study aimed discover novel biomarkers simple through integrative multi-omics analysis, uncovering their potential connections providing fresh research directions for the complex pathogenesis treatment strategies. Transcriptome, untargeted metabolome, 16 S rDNA sequencing were conducted on subjects examine transcripts, metabolites blood, gut microflora stool. Transcriptomic analysis identified 599 differentially expressed genes (DEGs), which 25 immune-related genes, participated immune pathways such as antimicrobial peptides, neutrophil degranulation, interferons. optimal random forest model based these exhibited an AUC 0.844. metabolomic examined 71 (DEMs), including 12 metabolites. Notably, lauric acid showed extremely strong positive correlation with BMI good discriminative power (AUC = 0.82). DEMs found be significantly enriched four metabolic pathways, namely "Aminoacyl-tRNA biosynthesis", "Valine leucine isoleucine biosynthesis, Glycine", "Serine threonine metabolism", "Biosynthesis unsaturated fatty acids". Microbiome revealed differential microbiotas (DGMs) at phylum genus levels, p_Firmicutes dominating obese group g_Escherichia-Shigella normal group. Subsequently, Random Forest was developed DEMs, DEGs, value 0.912. 14 indicators by this could potentially serve set obesity. inter-omics network 233 pairs correlations. DEGs BPIFA1, BPI, SAA1, Dimethy(tetradecyl)amine, Deoxycholic acid, Pathalic anhydride, DL-Alanine, DGMs g_Intestinimonas g_Turicibacter connectivity within network, constituting large proportion interactions. presents first comprehensive description characteristics obesity, recognizing promising biomarkers. Immune-related markers offer new perspective researching immunological mechanisms underlying its associated complications. interactions among contribute deeper understanding intricate biological regulatory networks

Language: Английский

Citations

1
(−)-Epigallocatechin-3-gallate (EGCG) ameliorates ovalbumin-induced asthma by inhibiting inflammation via the TNF-α/TNF-R1/NLRP3 signaling pathway DOI
Beibei Zhang, Mengnan Zeng,

Qimei Tie

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113708 - 113708

Published: Dec. 3, 2024

Language: Английский

Citations

1
NLRP3 Deficiency in Nonimmune Cells Averts Obesity-Induced Fatty Liver Disease DOI

Lilah Margalit Grigg,

Bander Abu Shrkihe,

Irina Efimova

et al.

Laboratory Investigation, Journal Year: 2023, Volume and Issue: 104(2), P. 100308 - 100308

Published: Dec. 20, 2023

Language: Английский

Citations

3
The NLRP3 inflammasome rs35829419 C>A polymorphism is associated with type 2 diabetes mellitus in Saudi Arabia DOI Open Access
Yahia A. Kaabi

Saudi Medical Journal, Journal Year: 2023, Volume and Issue: 44(8), P. 745 - 750

Published: Aug. 1, 2023

To investigate the frequency of NLRP3 gene rs35829419 C>A single-nucleotide polymorphism (SNP) in a Saudi Arabian population from Jazan (Southwest Arabia) and test its potential association with type 2 diabetes mellitus (T2DM).This case-control study included 546 volunteers (271 patients T2DM 275 healthy controls) recruited outpatient clinics at University Hospital King Fahad Central Jazan, Arabia, between December 2021 July 2022. Genomic DNA was extracted all samples genotyped for SNP using TaqMan technology. The examined logistic regression analysis.Overall genotype distributions were 90.5% (CC), 9.3% (CA), 0.2% (AA). heterozygous CA more frequent group (12.2%) compared to control (6.5%) analysis showed statically significant risk under codominant (CA versus CC; odds ratio [OR]=1.99; 95% confidence interval [CI]= [1.11-3.61]; p=0.0270), dominant (CA+AA OR=2.05; CI=[1.16-3.75]; p=0.019) models inheritance.This revealed our direct correlation having minor allele A higher developing T2DM. This highlights significance pathophysiology

Language: Английский

Citations

2
Obesity-associated Airway Hyperresponsiveness: Mechanisms Underlying Inflammatory Markers and Possible Pharmacological Interventions DOI
Manash Pratim Pathak, Pompy Patowary, Pronobesh Chattopadhyay

et al.

Endocrine Metabolic & Immune Disorders - Drug Targets, Journal Year: 2023, Volume and Issue: 24(9), P. 1053 - 1068

Published: Nov. 14, 2023

Obesity is rapidly becoming a global health problem affecting about 13% of the world's population women and children most. Recent studies have stated that obese asthmatic subjects suffer from an increased risk asthma, encounter severe symptoms, respond poorly to anti-asthmatic drugs, ultimately their quality-of-life decreases. Although, association between airway hyperresponsiveness (AHR) obesity growing concern among public due lifestyle environmental etiologies, however, precise mechanism underlying this yet establish. Apart aiming at conventional antiasthmatic targets, treatment should be directed towards ameliorating pathogenesis too. Understanding AHR limited, plethora pathologies been reported viz., pro-inflammatory decreased anti-inflammatory adipokines, depletion ROS controller Nrf2/HO-1 axis, NLRP3 associated macrophage polarization, hypertrophy WAT, down-regulation UCP1 in BAT following down-regulated AMPKα melanocortin pathway may correlated with AHR. Increased waist circumference (WC) or central was thought related AHR, some recent reports suggest body mass index (BMI), not WC tends exaggerate closure unknown mechanisms. This review aims co-relate above-mentioned mechanisms explain copious relation help published reports. A proper understanding these discussed will ensure appropriate plan for patients through advanced pharmacological interventions.

Language: Английский

Citations

2