Associations of gut microbiota alterations with clinical, metabolic, and immune-inflammatory characteristics of chronic schizophrenia

Journal of Psychiatric Research, Journal Year: 2024, Volume and Issue: 171, P. 152 - 160

Published: Jan. 23, 2024

Language: Английский

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Methanogenic archaea in the human gastrointestinal tract

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2022, Volume and Issue: 19(12), P. 805 - 813

Published: Sept. 1, 2022

Language: Английский

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New putative periodontopathogens and periodontal health‐associated species: A systematic review and meta‐analysis

Journal of Periodontal Research, Journal Year: 2023, Volume and Issue: 58(5), P. 893 - 906

Published: Aug. 10, 2023

Abstract To investigate the existence of any association between new putative periodontal pathogens and periodontitis. Two independent reviewers conducted electronic literature searches in MEDLINE (PubMed), EMBASE, DOSS Google Scholar databases as well a manual search to identify eligible clinical studies prior November 2022. Studies comparing prevalence microorganisms other than already‐known subgingival plaque and/or saliva samples subjects with periodontitis subject health were included. Meta‐analyses performed on data provided by included studies. Fifty including total 2739 1747 The Archaea domain 25 bacterial species ( Anaeroglobus geminatus , Bacteroidales [G‐2] bacterium HMT 274, Desulfobulbus sp. 041, Dialister invisus pneumosintes, Eubacterium brachy Enterococcus faecalis, nodatum saphenum Filifactor alocis Fretibacterium 360, 362, Mogibacterium timidum, Peptoniphilaceae 113, Peptostreptococcus stomatis, Porphyromonas endodontalis, Slackia exigua, Streptococcus gordonii Selenomonas sputigena Treponema amylovorum lecithinolyticum, maltophilum, medium, parvum socranskii ) found be statistically significantly associated Network should role these newly identified periodontitis‐associated through interspecies interaction host‐microbe crosstalk analyses.

Language: Английский

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Gut commensals and their metabolites in health and disease

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 8, 2023

Purpose of review This comprehensively discusses the role gut microbiome and its metabolites in health disease sheds light on importance a holistic approach assessing gut. Recent findings The consisting bacteriome, mycobiome, archaeome, virome has profound effect human health. Gut dysbiosis which is characterized by perturbations microbial population not only results gastrointestinal (GI) symptoms or conditions but can also give rise to extra-GI manifestations. microorganisms produce (short-chain fatty acids, trimethylamine, hydrogen sulfide, methane, so on) that are important for several interkingdom interactions functions. They participate various host metabolic processes. An alteration species affect their respective metabolite concentrations have serious implications. Effective assessment crucial as it provide insights into one’s overall Summary Emerging evidence highlights disease. As implicated GI well symptoms, plays well-being host. may status leading more care.

Language: Английский

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Exploring the human archaeome: its relevance for health and disease, and its complex interplay with the human immune system

FEBS Journal, Journal Year: 2024, Volume and Issue: unknown

Published: March 31, 2024

This Review aims to coalesce existing knowledge on the human archaeome, a less‐studied yet critical non‐bacterial component of microbiome, with focus its interaction immune system. Despite largely bacteria‐centric in microbiome research, archaea present unique challenges and opportunities for understanding health. We examine archaeal distribution across different body sites, such as lower gastrointestinal tract (LGT), upper aerodigestive (UAT), urogenital (UGT), skin. Variability composition exists between sites; methanogens dominate LGT, while Nitrososphaeria are prevalent skin UAT. Archaea have be classified pathogens but show associations conditions refractory sinusitis vaginosis. In methanogenic play metabolic roles by converting bacterial end‐products into methane, correlating various health conditions, including obesity certain cancers. Finally, this work looks at complex interactions system molecular level. Recent research has illuminated specific molecules, RNA glycerolipids, stimulating responses via innate receptors like Toll‐like receptor 8 (TLR8) ‘C‐type lectin domain family 4 member E’ (CLEC4E; also known MINCLE). Additionally, by‐products archaea, specifically demonstrated immunomodulatory effects through anti‐inflammatory anti‐oxidative pathways. these advancements, mechanistic underpinnings how influence activity remain fertile area further investigation.

Language: Английский

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Age-Related Dynamics of Methanogenic Archaea in the Human Gut Microbiome: Implications for Longevity and Health

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 12, 2024

Abstract The reciprocal relationship between aging and alterations in the gut microbiota is a subject of ongoing research. While role bacteria microbiome well-documented, specific changes composition methanogens during extreme impact high methane production general on health remain unclear. To address these questions, we analyzed metagenomic data from stool samples young adults (n=127, Age: 19-59 y), older (n=86), centenarians (n=34, age: 100-109 years). Our findings reveal compelling link age prevalence methanogen phenotype, while overall archaeal diversity diminishes. Surprisingly, appears more akin to that younger adults, showing an increase Methanobrevibacter smithii , rather than Ca. M. intestini. Remarkably, intestini emerged as central player network stability paving way for centenarians. Notably, exhibit highly complex stable two with other bacteria. Furthermore, mutual exclusion Lachnospiraceae throughout all groups suggests communities may compensate age-related drop by co-occurring butyrate-producing Oscillospiraceae. This study underscores crucial human physiology aging. It highlights shifts composition, emphasizing significance partnership enhanced potential longevity.

Language: Английский

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Microbial underdogs: exploring the significance of low-abundance commensals in host-microbe interactions

Experimental & Molecular Medicine, Journal Year: 2023, Volume and Issue: 55(12), P. 2498 - 2507

Published: Dec. 1, 2023

Our understanding of host-microbe interactions has broadened through numerous studies over the past decades. However, most investigations primarily focus on dominant members within ecosystems while neglecting low-abundance microorganisms. Moreover, laboratory animals usually do not have microorganisms beyond bacteria. The phenotypes observed in animals, including immune system, displayed notable discrepancies when compared to real-world observations due diverse microbial community natural environments. Interestingly, recent unveiled beneficial roles played by Despite their rarity, these keystone taxa play a pivotal role shaping composition and fulfilling specific functions host. Consequently, become imperative unravel true commensalism. In this review, we provide comprehensive overview important findings how commensal microorganisms, bacteria, fungi, archaea, protozoa, interact with host contribute phenotypes, emphasis system. Indeed, vital development host's influence disease status, key communities niches. Understanding microbes is will lead better relationships.

Language: Английский

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Methanogenic Archaea in the Pediatric Inflammatory Bowel Disease in Relation to Disease Type and Activity

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(1), P. 673 - 673

Published: Jan. 4, 2024

The inflammatory bowel disease (IBD) is associated with gut microbiota dysbiosis; however, studies on methanogens—especially those focused children—are extremely limited. aim of this study was to determine the abundance total methanogenic archaea and their three subgroups: Methanobrevibacter (Mb.) smithii, Methanosphaera (Ms.) stadtmanae, Methanomassiliicoccales, in feces children both active inactive Crohn’s (CD) ulcerative colitis (UC). results a quantitative real-time PCR were cross-referenced type (CD vs. UC) activity assessed use Pediatric Disease Activity Index (PCDAI) Ulcerative Colitis (PUCAI) indices, fecal calprotectin (FCP) concentration, compared controls. There significant decrease number methanogens CD UC prevalence also lower Furthermore, patients from group colonized by Mb. demonstrated most pronounced positive correlation between Ms. stadtmanae FCP concentration. Our demonstrate that are related pediatric IBD.

Language: Английский

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Emerging methods of human microbiome analysis and its forensic applications: Review

Forensic Science International Reports, Journal Year: 2024, Volume and Issue: 9, P. 100355 - 100355

Published: Jan. 22, 2024

The human microbiome comprises trillions of microbial cells, primarily bacteria, found in places such as the gut, oral cavity, and skin. holds significant potential forensic investigations, with important applications post-mortem analysis, geographical identifications, sexual assault cases, personal identification. displays variations, which can be utilized to distinguish individuals based on their distinctive signatures, thus facilitating Microbiome composition varies geographically explored for identification individuals' origin or location. In addition, changes observed during different stages decomposition provide valuable insight into time location death assist investigations. However, use microbiomes investigation is still developing under-utilized, especially world. This article reviewed emerging analyses, strengths, limitations, future research particular five microbiomic were looked at; postmortem identification, bite marks Despite challenges limitations associated storage sensitivity, limited samples, lack standardization, quite promising. should focus more extensive standardized studies overcome these fully harness enabling its practical application various scenarios.

Language: Английский

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Archaea in the Human Microbiome and Potential Effects on Human Infectious Disease

Emerging infectious diseases, Journal Year: 2024, Volume and Issue: 30(8)

Published: July 1, 2024

Archaea represent a separate domain of life, next to bacteria and eukarya. As components the human microbiome, archaea have been associated with various diseases, including periodontitis, endodontic infections, small intestinal bacterial overgrowth, urogenital tract infections. are generally considered nonpathogenic; reasons speculative because limited knowledge gene annotation challenges. Nevertheless, archaeal syntrophic principles that shape global microbial networks aid both potentially pathogenic bacteria. Evaluating interactions remains challenging, requiring clinical studies on inflammatory potential effects metabolism. Establishing culture collection is crucial for investigating functions within which could improve health outcomes in infectious diseases. We summarize nonpathogenicity, assess association diseases humans, discuss necessary experimental steps enable mechanistic involving archaea.

Language: Английский

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