Evaluation of the Effects of Age, Sex, and Dexpanthenol-Containing Skin Care on the Facial and Body Skin Microbiome DOI Creative Commons

Zainab Qaizar,

Raffaella de Salvo,

Gregor Bieri

et al.

Cosmetics, Journal Year: 2024, Volume and Issue: 11(6), P. 213 - 213

Published: Dec. 6, 2024

Given the pivotal role played by microbiome in skin health, it is important to understand how its composition varies with age, sex, and body site regular use of topical products. Four studies were carried out determine effects long-term (4-week) different dexpanthenol-containing products on a varied population cosmetically dry skin. The was assessed before after product usage. No significant changes richness or diversity found for individual test products; however, meta-analysis combined dataset did show as function subject’s site. work presented here demonstrates carefully formulated skin, when used way that representative real-life usage conditions, can respect microbial present across widely study population.

Language: Английский

The Urogenital System Microbiota: Is It a New Gamechanger in Urogenital Cancers? DOI Creative Commons
Gülfem Ece, Ahmet Aktaş, Ayşe Caner

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 315 - 315

Published: Feb. 1, 2025

The human microbiome, which encompasses microbial communities and their genetic material, significantly influences health disease, including cancer. urogenital microbiota, naturally present in the urinary genital tracts, interact with factors such as age, lifestyle, conditions to affect homeostasis carcinogenesis. Studies suggest that alterations this microbiota contribute development progression of genitourinary cancers, emphasizing concept oncobiome, refers contributions Similarly, gut can influence hormone levels systemic inflammation, impacting cancers cervical prostate Advanced studies indicate have distinct profiles may serve diagnostic biomarkers or therapeutic targets. Dysbiosis correlates bladder kidney Additionally, effectiveness cancer treatments. However, further research is necessary clarify causality, role metabolites, hormonal regulation. aim review understand these dynamics opportunities for innovative diagnostics therapies, highlighting need integration microbiology, oncology, genomics explore cancers. For this, a comprehensive search relevant databases was conducted, applying specific inclusion exclusion criteria identify examining association between Research into mechanisms by pave way new approaches, ultimately improving patient outcomes.

Language: Английский

Citations

0
Association of Gestational Diabetes Mellitus with Multi Drug Resistant Vaginal Infections among Pregnant Women DOI

Nauman Tariq,

Maryam Iqbal,

Mehwish Sheraz

et al.

Indus journal of bioscience research., Journal Year: 2025, Volume and Issue: 3(2), P. 245 - 252

Published: Feb. 25, 2025

Background: Vaginal infections caused by various pathogenic microorganisms, along with the emergence of antibiotic resistance, pose significant medical challenges. Gestational diabetes mellitus (GDM) is a critical factor that can delay recovery from and lead to complications. Methodology: This study was conducted as cross-sectional analysis involving pregnant women. A total 120 vaginal swabs were collected participants analyzed identify microorganisms present assess their susceptibility. The subjects categorized into two groups based on diabetic status: those GDM without. Various biochemical tests, culturing methods, sensitivity patterns performed high swab isolates. Results: revealed 56% women studied aged between 23 37 years, 67% in third trimester. Among identified, Candida species accounted for 51%, while gram-positive bacteria comprised 24.3% gram-negative 25.19%. Within category, Methicillin-resistant Staphylococcus aureus (MRSA) most prevalent at 30.25%, followed Enterococcus faecalis 15% Streptococcus 3.11%. For bacteria, Klebsiella pneumoniae found 44.4% cases, E. coli 31.3%, Pseudomonas aeruginosa 14.1%, stutzeri 6.05%, Acinetobacter baumannii 3.02%. Susceptibility testing indicated primarily sensitive Linezolid but resistant azithromycin, vancomycin cotrimoxazole effective against MRSA, cloxacillin showing resistance. Vancomycin also treatment faecalis, whereas azithromycin exhibited resistance levels. Gentamicin coli, Rofloxacin showed highest resistance; Imipenem P. aeruginosa, Amikacin association multidrug-resistant (MDR) GDM. Conclusion: concluded there no MDR gestational among

Language: Английский

Citations

0
Vaginal Lactobacilli Supernatants Protect from Herpes Simplex Virus Type 1 Infection in Cell Culture Models DOI Open Access
Elisa Avitabile, Laura Menotti, Barbara Giordani

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2492 - 2492

Published: Feb. 20, 2024

A healthy vaginal microbiota hosts Lactobacillus as the most predominant genus. Lactobacilli play a role in human health through production of diverse antimicrobial substances that can act against pathogens or modulate immune system. Previous reports highlighted ability lactobacilli to counteract viruses causing STIs, e.g., HIV-1 and HSV-2. In this report, we analyze activity supernatants HSV-1 infection, which is becoming increasingly relevant STI. We show two species (i.e., L. crispatus gasseri) were active at neutralizing infection different cell lines simian origin. Specifically, demonstrate strains are effective antiviral activity, evidenced by comparison with pathogen taken reference. The effect was specific not attributable generic toxicity cells. Our results pave way for development probiotics limit impact on women’s health.

Language: Английский

Citations

3
Protective Mechanisms of Vaginal Lactobacilli against Sexually Transmitted Viral Infections DOI Open Access
Elisa Avitabile, Laura Menotti,

Vanessa Croatti

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9168 - 9168

Published: Aug. 23, 2024

The healthy cervicovaginal microbiota is dominated by various Lactobacillus species, which support a condition of eubiosis. Among their many functions, vaginal lactobacilli contribute to the maintenance an acidic pH, produce antimicrobial compounds, and modulate host immune response protect against bacterial fungal infections. Increasing evidence suggests that these beneficial bacteria may also confer protection sexually transmitted infections (STIs) caused viruses such as human papillomavirus (HPV), immunodeficiency virus (HIV) herpes simplex (HSV). Viral STIs pose substantial public health burden globally, causing range infectious diseases with potentially severe consequences. Understanding molecular mechanisms exert protective effects viral paramount for development novel preventive therapeutic strategies. This review aims provide more recent insights into intricate interactions between STIs, exploring impact on microenvironment, response, infectivity pathogenesis, highlighting potential implications interventions clinical management

Language: Английский

Citations

3
A gender perspective on diet, microbiome, and sex hormone interplay in cardiovascular disease DOI Creative Commons
Nina Jovanović, Veronika Zach, Claudia Crocini

et al.

Acta Physiologica, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Abstract A unique interplay between body and environment embeds reflects host–microbiome interactions that contribute to sex‐differential disease susceptibility, symptomatology, treatment outcomes. These differences derive from individual biological factors, such as sex hormone action, sex‐divergent immune processes, X‐linked gene dosage effects, epigenetics, well their interaction across the lifespan. The gut microbiome is increasingly recognized a moderator of several systems are thus impacted by its function composition. In humans, components further interact with gender‐specific exposures dietary preferences, stressors, life experiences form complex whole, requiring innovative methodologies disentangle. Here, we summarize current knowledge among hormones, microbiota, system, vascular health relevance for epidemiology cardiovascular diseases. We outline clinical implications, identify gaps, place emphasis on required future studies address these gaps. addition, provide an overview caveats associated conducting research require consideration sex/gender differences. While previous work has inspected separately, here call attention translational utility combined perspective research, gender medicine, biology.

Language: Английский

Citations

3
An updated study of the relationship between bacterial infections and women's immune system, focusing on bacterial compositions with successful pregnancy DOI
Raed Obaid Saleh,

Omar Dheyauldeen Salahdin,

Irfan Ahmad

et al.

Journal of Reproductive Immunology, Journal Year: 2024, Volume and Issue: 165, P. 104283 - 104283

Published: June 25, 2024

Language: Английский

Citations

1
Understanding vaginal biofilms: The first step in harnessing antimicrobial nanomedicine DOI Creative Commons
Sybil Obuobi, Nataša Škalko‐Basnet

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 1190 - 1208

Published: Nov. 12, 2024

In spite of multipurpose technologies offering broad-spectrum prevention for sexually transmitted infections (STIs) and contraception, the STIs incidences rise worldwide. The situation is even more alarming considering continuous in antimicrobial resistance (AMR) that limits therapy options. this review we address specific challenges efficiently treating vaginal locally, at infection site, by understanding underlying barriers to efficient treatment such as biofilms. Knowledge on biofilms remains, up now, rather scarce requires attention. We therefore propose a 'back basics' insight seeks probe complexity role microbiota, its relationship with implications future therapeutic modalities utilizing advanced nano delivery systems. Our key objective highlight interplay between biofilm, (nano)formulation outcome than provide an overview all nanoformulations were challenged against focused anatomy female reproductive organ physiological changes from birth, unique microenvironment premenopausal postmenopausal women, biofilm current nanomedicine-based approaches treat site. Finally, offer our perspectives associated considerations can aid design development safer potent products persisting infections.

Language: Английский

Citations

1
Recent advances in in vitro models simulating the female genital tract toward more effective intravaginal therapeutic delivery DOI
Bruna Silva, Eduardo F. Marques, Andreia C. Gomes

et al.

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(7), P. 1007 - 1027

Published: July 2, 2024

Intravaginal drug delivery has emerged as a promising avenue for treating spectrum of systemic and local female genital tract (FGT) conditions, using biomaterials carriers or scaffolds targeted efficient administration. Much effort been made to understand the natural barriers this route improve system achieve an therapeutic response.

Language: Английский

Citations

0
Evaluation of the Effects of Age, Sex, and Dexpanthenol-Containing Skin Care on the Facial and Body Skin Microbiome DOI Creative Commons

Zainab Qaizar,

Raffaella de Salvo,

Gregor Bieri

et al.

Cosmetics, Journal Year: 2024, Volume and Issue: 11(6), P. 213 - 213

Published: Dec. 6, 2024

Given the pivotal role played by microbiome in skin health, it is important to understand how its composition varies with age, sex, and body site regular use of topical products. Four studies were carried out determine effects long-term (4-week) different dexpanthenol-containing products on a varied population cosmetically dry skin. The was assessed before after product usage. No significant changes richness or diversity found for individual test products; however, meta-analysis combined dataset did show as function subject’s site. work presented here demonstrates carefully formulated skin, when used way that representative real-life usage conditions, can respect microbial present across widely study population.

Language: Английский

Citations

0