Trends in the Epidemiology of Pneumocystis Pneumonia in Immunocompromised Patients without HIV Infection

Journal of Fungi, Journal Year: 2023, Volume and Issue: 9(8), P. 812 - 812

Published: July 31, 2023

The increasing morbidity and mortality of life-threatening

Language: Английский

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MICROBIAL PATTERNS AND DRUG SENSITIVITY TEST OF BACTERIAL AND FUNGAL INFECTION IN COVID-19 PATIENTS AT THE NATIONAL REFERRAL HOSPITAL IN NORTH SUMATRA, INDONESIA.

PubMed, Journal Year: 2025, Volume and Issue: 19(1), P. 36 - 44

Published: Jan. 1, 2025

Bacteria or fungi in COVID-19 involves several mechanisms that can affect immune system and also increase severity of symptoms. The incidence bacterial fungal infections is common patients with viral respiratory tract infections. aim this study was to determine the microbial patterns sensitivity tests infection at National Referral Hospital North Sumatra, Indonesia.

Language: Английский

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Analysis of adverse events induced by fluconazole based on FAERS database

Expert Opinion on Drug Safety, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Fluconazole, a widely used antifungal agent, has been associated with various adverse events (AEs). This study aimed to analyze the safety profiles of fluconazole using FDA Adverse Event Reporting System (FAERS) database provide insights for its safe use. Fluconazole-related AEs from 2004 2024Q2 were extracted FAERS database. The Odds Ratio (ROR) method was employed detect and signals. Additionally, impact COVID-19 on also examined. A total 7,720 identified, 40.3% being serious. most common involved skin, gastrointestinal, administration site reactions. High doses linked increased teratogenic risks. Weekly dosing regimens below 200 mg/day fewer severe AEs. During pandemic, there notable rise in reports drug inefficacy hepatic/renal damage. 45 new reactions identified. Conclusions: highlights importance monitoring liver, kidney, cardiovascular functions during use, especially high-risk populations. findings underscore need careful consideration interactions, particularly ensure effective use fluconazole.

Language: Английский

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Identification and characterization of a novel antifungal compound tubeimoside I targeting cell wall

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: 12(6)

Published: April 23, 2024

Due to fungal diseases that threaten immunocompromised patients, along with the limited availability of antifungal agents, there is an urgent need for new compounds treat infections. Here, we aimed identify potential drugs from natural products using fission yeast

Language: Английский

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Filamentous Fungi Infections: Yet Another Victim of COVID-19?

Life, Journal Year: 2023, Volume and Issue: 13(2), P. 546 - 546

Published: Feb. 15, 2023

Filamentous fungi have always been a matter of concern in the medical field, but nowadays, due to an increase risk factors and added infections with SARS-CoV-2 virus, they are slowly surely emerging as dangerous health threat worldwide. Our study aims estimate incidence mold central Romania, well assess impact pandemic had on them while evaluating other parameters such age, associated bacterial fungal comorbidities. Purulent discharge respiratory secretion specimens were collected analyzed over period 10 years. A total 68 samples tested positive for molds, increased number during pandemic. The highest came from outpatient department, followed by wards, most common filamentous fungus being Aspergillus section Flavi. Associated diseases included affections system, cardiovascular system people who suffered viral infection SARS-CoV-2, mostly present seniors. Staphylococcus aureus Candida nonalbicans. statistically significant correlation was found between association mortality.

Language: Английский

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Antifungal activity of the repurposed drug disulfiram against Cryptococcus neoformans

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 11, 2024

Fungal infections have become clinically challenging owing to the emergence of drug resistance in invasive fungi and rapid increase number novel pathogens. The development further restricts use antifungal agents. Therefore, there is an urgent need identify alternative treatments for

Language: Английский

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Changes in Spectrum of Respiratory Pathogen Infections and Disease Severity Among Children in Hohhot, China: Impact of COVID-19 Prevention Measures

Medical Science Monitor, Journal Year: 2024, Volume and Issue: 30

Published: Jan. 18, 2024

BACKGROUND:This retrospective study evaluated the effects of specific COVID-19 preventive measures, including use medical masks, nucleic acid testing, and patient isolation, on respiratory infections, disease severity, seasonal patterns among children in Hohhot, located northern China. Understanding these alterations is pivotal developing effective strategies to handle pediatric infections within context continuous public health initiatives. MATERIAL AND METHODS:At First Hospital throat swabs were collected from 605 with community-acquired between January 2022 March 2023 for pathogen infection spectrum detection using microarray testing. RESULTS:Among patients, 56.03% male, their average age was 3.45 years. SARS-CoV-2 highest October 2023. Influenza A peaked 2023, other pathogens such as syncytial virus influenza B disappeared after December 2022. The proportion mixed 41.94% while had rates exceeding 57.14%. Before 2022, mean WBC count Streptococcus pneumoniae Haemophilus influenzae 8.83×10⁹/L, CRP 18.36 mg/L, PCT 1.11 ng/ml. After values decreased significantly. Coughing, difficulty breathing, running nose, lower tract diagnoses except infections. CONCLUSIONS:SARS-CoV-2 around November like greatly reduced Inflammatory markers symptoms SARS-CoV-2.

Language: Английский

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Hospital antimicrobial stewardship: profiling the oral microbiome after exposure to COVID-19 and antibiotics

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 27, 2024

Introduction During the COVID-19 Delta variant surge, CLAIRE cross-sectional study sampled saliva from 120 hospitalized patients, 116 of whom had a positive PCR test. Patients received antibiotics upon admission due to possible secondary bacterial infections, with patients at risk sepsis receiving broad-spectrum (BSA). Methods The samples were analyzed shotgun DNA metagenomics and respiratory RNA virome sequencing. Medical records for period hospitalization obtained all patients. Once outcomes known, classified based on their disease severity they received. Results Our reveals that BSA regimens differentially impacted human salivary microbiome progression. 12 died them BSA. Significant associations found between composition use, SARS-CoV-2 genome coverage disease. We also significant non-bacterial disease, Candida albicans detected most frequently in critical For who did not receive before sampling, our suggests Staphylococcus aureus as potential factor sepsis. Discussion results indicate course infection may be explained by both monitoring antibiotic treatment profiling patient’s microbiome, establishing compelling link specific type timing treatment. This approach can aid emergency room triage inpatient management but requires better understanding access narrow-spectrum agents target pathogenic bacteria.

Language: Английский

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Coinfección o sobreinfección fúngica en pacientes con COVID-19 en un hospital de tercer nivel en México

Biomédica, Journal Year: 2024, Volume and Issue: 44(3), P. 328 - 339

Published: Aug. 29, 2024

Introducción. Los datos sobre la prevalencia de coinfecciones o sobreinfecciones fúngicas en pacientes con COVID-19 son limitados.Objetivo. Describir COVID-19, así como los factores riesgo y las características demográficas, clínicas microbiológicas.Material métodos. Se incluyeron diagnóstico confirmado hospitalizados unidad cuidados intensivos infección fúngica confirmada entre marzo del 2020 diciembre 2021. Del expediente clínico se obtuvieron edad, sexo, comorbilidades, días estancia hospitalaria, resultados laboratorio (ferritina) microbiológicos, tratamiento contra terapia antifúngica desenlace.Resultados. Once 740 cumplieron criterios inclusión. La tasa coinfección fue 0,3 % sobreinfección 1,2 %. población más afectada hombres adultos. Las diagnosticadas fueron candiduria candidemia, causadas por Candida albicans, C. tropicalis, glabrata, lusitaniae Kluyveromyces marxianus (C. kefyr). Además, encontró una traqueobronquitis Aspergillus fumigatus. antifúngicos administrados fluconazol caspofungina. letalidad 50 fúngicas, 22 El tiempo intrahospitalaria 11 a 65 días. Ocho requirieron asistencia respiratoria mecánica seis recibieron corticoides. principal comorbilidad diabetes mellitus (81,8 %).Conclusiones. hongos baja, pero estas requiere, urgencia, realización pruebas rutina para detectar grave diagnosticar oportunamente infecciones que puedan comprometer aún vida paciente

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Computer-aided Drug Discovery Approaches in the Identification of Natural Products against SARS-CoV-2: A Review

Current Computer - Aided Drug Design, Journal Year: 2023, Volume and Issue: 20(4), P. 313 - 324

Published: March 30, 2023

The COVID-19 pandemic is raising a worldwide search for compounds that could act against the disease, mainly due to its mortality. With this objective, many researchers invested in discovery and development of drugs natural origin. To assist search, potential computational tools reduce time cost entire process known. Thus, review aimed identify how these have helped identification products SARS-CoV-2. For purpose, literature was carried out with scientific articles proposal where it possible observe different classes primary and, mainly, secondary metabolites were evaluated molecular targets, mostly being enzymes spike, using techniques, emphasis on use docking. However, noted silico evaluations still much contribute an anti- SARS-CoV-2 substance, vast chemical diversity products, targets advancement.

Language: Английский

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