Antibiofilm Effects of Novel Compounds in Otitis Media Treatment: Systematic Review DOI Open Access
Ana Jotić, Katarina Savić Vujović, Andja Ćirković

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12841 - 12841

Published: Nov. 29, 2024

Otitis media (OM) is a frequent disease with incidence rate of 5300 cases per 100,000 people. Recent studies showed that polymicrobial biofilm formation represents significant pathogenic mechanism in recurrent and chronic forms OM. Biofilm enables bacteria to resist antibiotics would typically be recommended guidelines, contributing the ineffectiveness current antimicrobial strategies. Given challenges successfully treating bacterial biofilms, there an growing interest identifying novel effective compounds overcome antibacterial resistance. The objective this review was provide overview antibiofilm effects on formed by clinical isolates systematic included evaluated effect natural or synthetic from obtained patients eligibility criteria were defined using PICOS system: (P) Population: all human OM; (I) Intervention: compound effect; (C) Control standard therapeutic agents untreated (O) Outcome: (biofilm inhibition, eradication), (S) Study design. PRISMA protocol for reviews meta-analysis followed. From 3564 potentially eligible studies, 1817 duplicates removed, 1705 excluded according exclusion criteria. A total 41 available full texts retrieved two independent authors. Fifteen articles selected inclusion which 125 17 different examined, including N-acetyl-L-cysteine (NAC), tea tree oil, xylitol, eugenol, Aloe barbadensis, Zingiber officinale, Curcuma longa, Acacia arabica, antisense peptide nucleic acids, probiotics Streptococcus salivarius oralis, Sodium 2-mercaptoethanesulfonate (MESNA), bioactive glass, green synthesized copper oxide nanoparticles, radish, silver nanoparticles acetic acid. Staphylococcus aureus most commonly studied pathogen, followed Pseudomonas aeruginosa Haemophilus influenzae. inhibition only examined assessed six studies; eradication four both five studies. This indicates some like NAC, prebiotics, MESNA have are safe could researched more extensively further use. However, lack data about reliable efficient used therapy types otitis still remains literature.

Language: Английский

Photosensitized Methylene Blue Nanoparticles: A Promising Approach for the Control of Oral Infections DOI Creative Commons

Magali Parizzi,

Aline Rosa Almeida,

Gabriel Lucca de Oliveira Salvador

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 673 - 673

Published: March 10, 2025

Introduction: Oral infections pose significant public health challenges, often exacerbating other comorbidities and increasing systemic risks. Traditional treatments fail to eliminate persistent micro-organisms contribute the rise of antimicrobial resistance. Nanoparticulate systems offer a promising solution by delivering active agents directly targeted sites, providing more effective localized treatment options. Objective: This study aimed synthesize characterize methylcellulose nanoparticles containing methylene blue at different concentrations using nanoprecipitation method. We also evaluated their biocompatibility activity against key commonly found in oral infections. Methods: The involved physicochemical morphological characterizations, including encapsulation efficiency, particle size, polydispersity index, zeta potential, transmission electron microscopy (TEM). Additionally, controlled release profiles, efficacy major pathogens, vitro assessments were performed. Results: results revealed efficiency between 99.1 98.8%, with sizes ranging from 186 274 nm potential 1.7 2.9 mV achieved lower methylcellulose. demonstrated sustained drug 85% for smaller particles 45% larger than 10 h. exhibited superior compared pure blue. Cell viability studies indicated that biocompatible approximately 40% cell nanoparticles. Conclusions: These findings suggest could serve as adjunct dental treatments. They action while potentially reducing development

Language: Английский

Citations

0
Harnessing green nanoparticles: Sustainable solutions for combating dental caries management DOI
Ramasamy Ramasubburayan,

Ganesan Ramanathan,

S.J. Vijay

et al.

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 45, P. 102631 - 102631

Published: March 11, 2025

Language: Английский

Citations

0
The current use of nanotechnology in the fight against antimicrobial resistance: promising approaches to global health challenge DOI
Gideon Sadikiel Mmbando,

Ombeni Ally,

Shedrack Reuben Kitimu

et al.

Journal of Nanoparticle Research, Journal Year: 2025, Volume and Issue: 27(4)

Published: April 1, 2025

Language: Английский

Citations

0
Bioinspired Nanomaterials to Combat Microbial Biofilm and Pathogen Challenges: A Review DOI
Atefeh Zarepour, Meenakshi Venkateswaran, Arezoo Khosravi

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(22), P. 25287 - 25313

Published: Nov. 12, 2024

The emergence of antibiotic-resistant biofilms poses a significant challenge in healthcare, as these complex microbial communities demonstrate an increased resistance to conventional treatment methods. Traditional antibiotics often fail against biofilms, resulting persistent infections and failures. To address this urgent issue, innovative strategies such bioinspired nanomaterials, antimicrobial peptides, quorum sensing inhibitors, combination therapies show promise disrupting biofilm structures, enhancing activity, overcoming mechanisms. Bioinspired nanomaterials have emerged pivotal approach for tackling the challenges presented by pathogens across various sectors, including industry, environmental protection. Their advantages include enhanced biocompatibility, targeted delivery, improved efficacy formation threats. Recent advancements highlight potential solutions, nanoparticles, smart nanocarriers, surface modifications, nanozymes, combating biofilm-related issues. Despite progress nanomaterial research, remain. intricate interactions within evolving nature necessitate multidisciplinary approaches. Furthermore, translating laboratory findings into practical applications faces obstacles related scalability, stability, regulatory compliance. Future are expected focus on multifunctional nanoparticles that disrupt advanced modifications better interaction, nanocarriers nanozymes dismantle structures. This review focuses development application pathogen challenges. It emphasizes roles targeting capabilities. Additionally, explores formulating management practices, providing insights advantages, limitations, future perspectives

Language: Английский

Citations

3
Antibacterial and antibiofilm effect of Zinc Oxide nanoparticles on P. aeruginosa variants isolated from young patients with cystic fibrosis DOI

Mona Konkuri,

Sharmin Kharrazi, Yousef Erfani

et al.

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 195, P. 106854 - 106854

Published: Aug. 14, 2024

Language: Английский

Citations

1
Antibiofilm and antibacterial activities of green synthesized ZnO nanoparticles against Erwinia amylovora and Pseudomonas syringae pv. Syringae: in vitro and in silico investigations DOI

Roozbeh Shakerdarabad,

Hassan Mohabatkar, Mandana Behbahani

et al.

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 196, P. 107011 - 107011

Published: Oct. 11, 2024

Language: Английский

Citations

1
Development of Halloysite Nanohybrids-Based Films: Enhancing Mechanical and Hydrophilic Properties for Wound Healing DOI Creative Commons

Francisco Ramón Rodríguez Pozo,

Daiana Ianev,

Tomás Martínez Rodríguez

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1258 - 1258

Published: Sept. 27, 2024

Most of the therapeutic systems developed for managing chronic skin wounds lack adequate mechanical and hydration properties, primarily because they rely on a single component. This study addresses this issue by combining organic inorganic materials to obtain hybrid films with enhanced behavior, adhesion, fluid absorption properties. To that aim, chitosan/hydrolyzed collagen blends were mixed halloysite/antimicrobial nanohybrids at 10% 20% (

Language: Английский

Citations

0
Antibiofilm Effects of Novel Compounds in Otitis Media Treatment: Systematic Review DOI Open Access
Ana Jotić, Katarina Savić Vujović, Andja Ćirković

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12841 - 12841

Published: Nov. 29, 2024

Otitis media (OM) is a frequent disease with incidence rate of 5300 cases per 100,000 people. Recent studies showed that polymicrobial biofilm formation represents significant pathogenic mechanism in recurrent and chronic forms OM. Biofilm enables bacteria to resist antibiotics would typically be recommended guidelines, contributing the ineffectiveness current antimicrobial strategies. Given challenges successfully treating bacterial biofilms, there an growing interest identifying novel effective compounds overcome antibacterial resistance. The objective this review was provide overview antibiofilm effects on formed by clinical isolates systematic included evaluated effect natural or synthetic from obtained patients eligibility criteria were defined using PICOS system: (P) Population: all human OM; (I) Intervention: compound effect; (C) Control standard therapeutic agents untreated (O) Outcome: (biofilm inhibition, eradication), (S) Study design. PRISMA protocol for reviews meta-analysis followed. From 3564 potentially eligible studies, 1817 duplicates removed, 1705 excluded according exclusion criteria. A total 41 available full texts retrieved two independent authors. Fifteen articles selected inclusion which 125 17 different examined, including N-acetyl-L-cysteine (NAC), tea tree oil, xylitol, eugenol, Aloe barbadensis, Zingiber officinale, Curcuma longa, Acacia arabica, antisense peptide nucleic acids, probiotics Streptococcus salivarius oralis, Sodium 2-mercaptoethanesulfonate (MESNA), bioactive glass, green synthesized copper oxide nanoparticles, radish, silver nanoparticles acetic acid. Staphylococcus aureus most commonly studied pathogen, followed Pseudomonas aeruginosa Haemophilus influenzae. inhibition only examined assessed six studies; eradication four both five studies. This indicates some like NAC, prebiotics, MESNA have are safe could researched more extensively further use. However, lack data about reliable efficient used therapy types otitis still remains literature.

Language: Английский

Citations

0