Effects of polypeptidin feeding on growth and intestinal flora of Apostichopus japonicus DOI Creative Commons
Xiaolan Huang,

Rubiao Xie,

Ange Zou

et al.

Aquaculture Reports, Journal Year: 2024, Volume and Issue: 38, P. 102284 - 102284

Published: Aug. 3, 2024

Language: Английский

Lipopeptides from Bacillus: unveiling biotechnological prospects—sources, properties, and diverse applications DOI
Diksha Saiyam, Anamika Dubey, Muneer Ahmad Malla

et al.

Brazilian Journal of Microbiology, Journal Year: 2024, Volume and Issue: 55(1), P. 281 - 295

Published: Jan. 13, 2024

Language: Английский

Citations

16
Lipopeptide C17 Fengycin B Exhibits a Novel Antifungal Mechanism by Triggering Metacaspase-Dependent Apoptosis in Fusarium oxysporum DOI

Yingjie Deng,

Zheng Chen, Yanping Chen

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(14), P. 7943 - 7953

Published: March 26, 2024

Fusarium wilt is a worldwide soil-borne fungal disease caused by oxysporum that causes serious damage to agricultural products. Therefore, preventing and treating fusarium of great significance. In this study, we purified ten single lipopeptide fengycin components from Bacillus subtilis FAJT-4 found C17 B inhibited the growth F. FJAT-31362. We observed early apoptosis hallmarks, including reactive oxygen species accumulation, mitochondrial dysfunction, phosphatidylserine externalization in B-treated cells. Further data showed induces cell metacaspase-dependent manner. Importantly, expression autophagy-related genes TOR signaling pathway was significantly upregulated; simultaneously, accumulation acidic autophagy vacuoles indicated activated during induced B. study provides new insights into antifungal mechanism fengycin.

Language: Английский

Citations

13
Recent advances in the application of microbial biosurfactants in food industries: Opportunities and challenges DOI

Anushree Roy,

Mojibur R. Khan, Ashis K. Mukherjee

et al.

Food Control, Journal Year: 2024, Volume and Issue: 163, P. 110465 - 110465

Published: March 25, 2024

Language: Английский

Citations

10
Iterative acylation on mature lasso peptides by widespread acetyltransferases for lipolasso production DOI Creative Commons

Jiang Xiong,

Sheng-Ze Wu,

Z. Li

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Abstract The biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs) leverages iterative catalysis to enhance structural biological diversity. Traditionally, enzymes install multiple post-translational modifications (PTMs) on linear peptides, rather than mature RiPPs with intricate three-dimensional structures, which would require complex changes in substrate binding poses. Here, we present a prolific class GCN5-related N-acetyltransferases (GNATs) that iteratively consecutively acylate two Lys residues within the loop ring motifs lasso diverging from typical modification peptides—an unprecedented function for PTM enzymes. Utilizing high-resolution cryo-electron microscopy enzymatic reconstitution, mapped peptide pocket IatT pinpointed key involved demarcating distinct acetylation steps. Structure-based engineering IatT’s acetyl group recognition site expanded cavity accommodate longer-chain acyl groups, leading creation lipolasso novel ribosomal lipopeptide. This strategy can be applied any RiPP BGC encoding GNAT, facilitating efficient diversification rare lipopeptides. Graphic

Language: Английский

Citations

1
Sources of Lipopeptides and Their Applications in Food and Human Health: A Review DOI Creative Commons
Shuyi Chen,

Chen Sumin,

Yu Xin

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(2), P. 207 - 207

Published: Jan. 10, 2025

Lipopeptides (LPs) are widely sourced surface-active natural products with a wide range of functions and low toxicity, high potency, good biodegradability. In this paper, we summarize, for the first time, plant, animal, microbial, synthetic sources LPs. We also introduce applications LPs in food human health, including (1) can inhibit growth microorganisms during production preservation. They be added to packaging materials preservation freshness transportation, used as additives improve taste food. (2) provide amino acids promote protein synthesis cellular repair. Due their broad-spectrum antimicrobial properties, they exhibit anticancer effects biological activities. This review summarizes, laying foundation development application

Language: Английский

Citations

1
Structural diversity and applications of lipopeptide biosurfactants as biocontrol agents against phytopathogens: A review DOI Creative Commons
Asma Sani, Wan‐Qi Qin, Jiayi Li

et al.

Microbiological Research, Journal Year: 2023, Volume and Issue: 278, P. 127518 - 127518

Published: Oct. 14, 2023

Language: Английский

Citations

22
Microbial lipopeptides: their pharmaceutical and biotechnological potential, applications, and way forward DOI

K. P. Sreelakshmi,

M. Madhuri,

R. Swetha

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 40(4)

Published: March 15, 2024

Language: Английский

Citations

7
Genome Sequencing and Characterization of Bacillus velezensis N23 as Biocontrol Agent against Plant Pathogens DOI Creative Commons
Panlei Yang, Qingchao Zeng, Wenxiao Jiang

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(2), P. 294 - 294

Published: Jan. 30, 2024

The overuse of chemical fungicides against fungal pathogens adversely affects soil and plant health, resulting in environmental problems food safety. Therefore, biocontrol is considered as an environmentally friendly cost-effective green technique protection agricultural production. We obtained a bacterial strain N23 from contaminated plate which showed significant inhibition to anthracnose. was identified Bacillus velezensis based on 16S rRNA gene, gyrA whole-genome sequence. bacterium able suppress the mycelial growth numerous pathogenic fungi solid media. Tomato seeds treated with significantly higher germination levels than untreated ones. Moreover, effectively reduced lesion area pepper anthracnose disease planta. gene clusters responsible for antifungal metabolites (fengycin, surfactin, iturin) were genome sequence mining PCR. Furthermore, methanol extracts culture caused Colletotrichum sp. Botrytis cinerea. These findings suggested that B. could be potential agent production source antimicrobial compounds further exploitation.

Language: Английский

Citations

5
Endophytic Bacillus amyloliquefaciens Mdgb15 is a potential biocontrol agent against tree peony gray mold caused by Botrytis cinerea DOI
Ruixian Yang, Wenyu Ye, Ping Liu

et al.

European Journal of Plant Pathology, Journal Year: 2024, Volume and Issue: 169(2), P. 431 - 445

Published: March 4, 2024

Language: Английский

Citations

5
Fermentation optimization and metabolomic analysis of a Bacillus subtilis co-culture system for fengycin production from mixed sugars DOI

Pengsheng Zhang,

Ying Yin, Jianping Wen

et al.

Biochemical Engineering Journal, Journal Year: 2024, Volume and Issue: 209, P. 109406 - 109406

Published: June 18, 2024

Language: Английский

Citations

4