Anti-angiogenic and anti-oxidant effects of 2-NTI indole derivative vs. suramin in ex vivo, in vivo, and in vitro studies

Cytotechnology, Journal Year: 2025, Volume and Issue: 77(1)

Published: Jan. 7, 2025

Language: Английский

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Therapeutic effect of bosentan on 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis mouse model

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Feb. 18, 2025

Language: Английский

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Inhibitory effects of carbohydrazide indole derivative on micro-blood vessel growth using ex vivo, in vivo, and in vitro assays

In Vitro Cellular & Developmental Biology - Animal, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Language: Английский

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Protective effect of orientin on diabetic nephropathy in rat models of high-fat diet and streptozotocin-induced diabetes

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

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The Possible effect of Bosentan on the methotrexate-induced salivary gland changes in male rats: histological and Immunohistochemical study

Toxicology Research, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 31, 2024

Abstract Methotrexate (MTX) is an antimetabolite drug utilized for managing a variety of cancers and autoinflammatory conditions. MTX may trigger detrimental effects in mout, h tissues, including salivary gland impairment. Bosentan (BOS), that blocks endothelin receptors, has strengthened antioxidant, anti-inflammatory, anti-apoptotic properties. The study aimed to estimate the protective effect BOS on MTX-exacerbated changes Wistar Albino rats. Thirty male rats were arbitrarily sorted into three groups ten animals each. control group received normal saline 18 days. (induction) (25 mg/kg) intraperitoneally 7th day experiment once daily 6 consecutive + (50 orally days: days before induction, 2-h after post-induction. Animals euthanized 19, tissues dissected biochemical, histopathological, immunohistochemical analyses. dramatically improved MTX-aggravated biochemical histopathological abnormalities, as evidenced by diminished Bax, caspase 3, TNF-α, IL-1β, MDA, MPO levels, increased SOD, GSH, GPX reduced degenerative granular convolute tubule, mucous acini, striate duct. further substantially upregulated MTX-induced decline Ki-67 Bcl-2, indicated immunohistochemistry scoring methods. anti-oxidative, ant-inflammatory, antiapoptotic properties are promising strategy ameliorating toxic submandibular glandular tissues.

Language: Английский

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Impacts of designed vanillic acid-polymer-magnetic iron oxide nanocomposite on breast cancer cells

Heliyon, Journal Year: 2024, Volume and Issue: 10(12), P. e32863 - e32863

Published: June 1, 2024

The engineered nano-vehicle was constructed using magnetic iron oxide nanoparticles (MIONs) and chitosan (CTS) to stabilize anticancer agent vanillic acid (VNA) which loaded on CTS-coated MIONs nanocarrier, more importantly, achieve sustained VNA release subsequent proper activity. new thermally stable VNA-CTS- nanocomposite spherical with a middle diameter of 6 nm had high drug loading about 11.8 %. resulting were composed pure magnetite therefore, superparamagnetic saturation magnetizations 53.3 45.7 emu.g−1, respectively. profiles from VNA-CTS-MIONs in different pH values showed controlled pH-responsive delivery the 89 % 74 percentage within 2354 4046 min at 5 7.4, respectively, as well accordance pseudo-second-order model. treatment diverse concentrations remarkably decreased viability promoted ROS accumulation apoptosis MDA-MB-231 breast cancer cells. Hence, it can be propitious candidate for management future.

Language: Английский

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The role of Juniperus Macrocarpa extract as anti-inflammatory and antioxidant on methotrexate-induced acute liver injury in rat model

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 131 - 131

Published: Jan. 27, 2025

Methotrexate (MTX) is an antifolate medication indicated to treat array of tumors and autoinflammatory maladies. MTX may exhibit harmful impacts on multiple organs, especially liver injury cirrhosis. Juniperus macrocarpa a medicinal herb enriched with polyphenols flavonoids featuring robust anti-inflammatory antioxidative benefits. To evaluate the hepatoprotective effects aqueous extract MTX-aggravated toxicity. The study involved 20 male middle-aged albino rats, arbitrarily allocated into 4 groups 5 animals each. Group 1 (control) were given distilled water (DW) once daily for two weeks. 2 got intraperitoneal single dose (20 mg/kg) Rats in 3 dosages 100 mg 200 extract, respectively, weeks before receiving injection. extracts at both low high doses substantially alleviated MTX-provoked biochemical alterations, as evidenced by decreased levels inflammatory parameters including TNF-α IL-6 hepatic enzymes ALT, AST, ALP. also significantly boosted anti-oxidant like SOD GPX. Moreover, attenuated congestive degenerative changes, improved histopathological findings. anti-oxidative activities are promising approach ameliorating hepatotoxicity.

Language: Английский

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Site-specific drug delivery: Molecular insights into the pH-dependent dissociation of carbon dot-carnosine peptide conjugates via DFT studies

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 127186 - 127186

Published: Feb. 1, 2025

Language: Английский

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The potential effects of cranberry extract on indomethacin-induced gastric ulcer in rats

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 257 - 257

Published: March 4, 2025

Background Indomethacin (IND) belongs to nonsteroidal anti-inflammatory drugs (NSAIDs) prescribed for treatment of rheumatoid diseases and linked the development gastric ulcers in many people. Cranberry is a rich source polyphenols flavonoids, which have powerful antioxidant properties. Methods This study aimed evaluate activity cranberry aqueous extract on IND-induced albino rats. Twenty-four adult male rats were sequentially assigned four groups six each. The control group consumes distilled water (DW) orally 15 days. IND (induction) received single oral dosage (60 mg/kg) IND. omeprazole (OMP) got 60 mg/kg as dose then 20 mg/kg/day OMP was given subsequently 200 Rats euthanized day 16, tissues removed biochemical histopathological evaluations. Results considerably ameliorated severity ulcerations fixed histological deteriorations. Furthermore, IND-exposed treated with exhibited dramatically lower serum levels inflammatory biomarkers like TNF-α IL-6, but higher anti-oxidative SOD GPx. bioactive flavonoids content could possibly account its profound gastroprotective effects. properties be promising strategy ameliorating IND-aggravated gastrotoxicity.

Language: Английский

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Computational evaluation of Ni@B12N12 and Ti@B12N12 endohedral clusters as carriers for melphalan and sulforaphane anticancer drugs

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 127457 - 127457

Published: March 1, 2025

Language: Английский

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